Navigation Links
How cells change gears: New insights published in Nature Genetics
Date:4/20/2009

ls. Understanding the role of the transcriptional network during differentiation in leukemia cells could offer a glimpse into the cause of leukemia, or offer possible approaches for treating leukemia, according to Ravasi.

During the laboratory phase of the project, researchers introduced a compound that stopped cell proliferation in the myeloid leukemia cell line. Next, they collected as much information as possible regarding the activity of the transcription factor network during the processes of differentiation and maturation into immune cells known as monocytes and macrophages. Computational work performed at UC San Diego after all the laboratory data had been collected allowed the researchers to identify specific subnetworks of transcription factors that were activated at particular time points.

Integrative Biology

The UCSD researchers were challenged to integrate different but related data sets in order to tease out real signals from noise. This is known as "integrative biology."

"We take lots of measurements of the same thingwe integrate them together," which leads to higher confidence in experimental results, Ravasi explained. Measuring both messenger RNA and protein levels, is one example. Detection of both signals provides two independent data points indicating the presence of the same protein.

"Getting to be the first to analyze and make sense of this large and fascinating data set was a huge opportunity," said Ravasi. The UC San Diego bioinformatics team working on this project included Ravasi and two post-doctoral researchers from Trey Ideker's bioengineering laboratory, Ariel Schwartz, now at Synthetic Genomics, and Kai Tan, now an assistant professor of internal medicine and biomedical engineering at the University of Iowa.

By monitoring the activity of the transcriptional network one hour after the onset of differentiation, the researchers identified a gene that appears to play an important
'/>"/>

Contact: Daniel Kane
dbkane@ucsd.edu
858-534-3262
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study Finds Blood Cells Can Be Reprogrammed to Act as Embryonic Stem Cells
2. Human stem cells promote healing of diabetic ulcers
3. Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells
4. USC researchers develop new drug to target tumor cells and blood vessels
5. Transplanted liver cells function in older animals but do not proliferate as much as in younger ones
6. Study Reveals How Salmonella Hijacks Cells
7. New Technology Allows Better Monitoring of Cancer Cells
8. A new method for bone-marrow-derived liver stem cells isolation and proliferation
9. Stem Cells Buy Freedom From Insulin for Type 1 Diabetics
10. Three Medical Centers Awarded Funds to Study Generation of Cardiac Muscle Cells
11. UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How cells change gears: New insights published in Nature Genetics
(Date:7/31/2015)... ... July 31, 2015 , ... Facebook, Twitter, Linkedin and ... their social media profiles to better connect with the public. The agency website ... information, share insights and opinions. The Rally Insurance Group, Inc.’s pledge to provide ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... According to ... cosmetic experts gathered to see if they could reach a consensus on the steps ... augmentation and facelifts. Overall, the group reached 90 percent consensus on a series of ...
(Date:7/31/2015)... ... July 31, 2015 , ... The 2015 New York ... family members, medical professionals, and researchers, covering a variety of topics related to ... collaborative effort between the Mesothelioma Applied Research Foundation and Memorial Sloan Kettering Cancer ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... been recognized in the 2015 Aster Awards national competition for a marketing communications ... Ocean City and surrounding communities in Coastal Maryland and Southern Delaware. , A ...
(Date:7/31/2015)... ... 31, 2015 , ... Recently, ZKB filed another federal lawsuit ... (Case No. 3:15-cv-00397) involving the Implanon® contraceptive implant . , As described ... Implanon® implants, inability to locate the implants, unsuccessful and invasive attempts at implant ...
Breaking Medicine News(10 mins):Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 3Health News:New York Area Mesothelioma Specialists to Present at Conference 2Health News:New York Area Mesothelioma Specialists to Present at Conference 3Health News:Mullin/Ashley Associates Wins in the 2015 Aster Awards National Competition for Excellence in Medical Marketing 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 3
... MAQUET Cardiovascular LLC,announced today that it was served ... (Terumo CSC) in the United States District,Court for ... that,MAQUET,s VASOVIEW Endoscopic Vessel Harvesting Systems infringe a ... patent infringement complaints against,Terumo CSC and Terumo Corporation ...
... SANTA YNEZ VALLEY, Calif., Sept. 2 Platinum Performance,client McLain ... Summer Olympics in Beijing, China, on August 19, as "probably ... sport.", Winning the first ever jump-off in Olympic Games ... the Team Show Jumping title at the Hong Kong,Olympic Equestrian ...
... CORAL GABLES, Fla., Sept. 2 MBF ... publicly traded special purpose,acquisition company, announced today ... MBH,s proposed acquisition of Critical Homecare Solutions,Holdings, ... stock purchase,agreement dated February 6, 2008 (the ...
... LANCASTER, Pa., Sept. 2 Herley Industries,Inc. (Nasdaq: ... manufacture of,microwave technology solutions for the defense, aerospace and ... a division of Jefferies & Company, Inc., as its ... strategic alternatives., Myron Levy, Chairman and CEO, said, ...
... and Providers Contain Costs and ... Improve Patient Outcomes Together, HOUSTON, Sept. ... Oncology, a service division that offers a first-time,opportunity for oncologists ... for the complexity of cancer,care. With a unique focus on ...
... even a year after routine was stopped, study says ... may help treat memory problems in adults, according to ... 138 people age 50 and older at increased risk ... led to modest improvements in cognitive function in adults ...
Cached Medicine News:Health News:MAQUET Cardiovascular Responds to Terumo Complaint About VASOVIEW Endoscopic Vessel Harvesting Systems 2Health News:Platinum Performance Clients Take Home Medals for the USA 2Health News:MBF Healthcare Acquisition Corp. Amends Stock Purchase Agreement With Critical Homecare Solutions Holdings, Inc. to Extend Termination Date to October 31, 2008 2Health News:MBF Healthcare Acquisition Corp. Amends Stock Purchase Agreement With Critical Homecare Solutions Holdings, Inc. to Extend Termination Date to October 31, 2008 3Health News:MBF Healthcare Acquisition Corp. Amends Stock Purchase Agreement With Critical Homecare Solutions Holdings, Inc. to Extend Termination Date to October 31, 2008 4Health News:Herley Industries, Inc. Engages Jefferies Quarterdeck to Explore Strategic Alternatives 2Health News:US Oncology Launches New Services Division: Innovent Oncology 2Health News:US Oncology Launches New Services Division: Innovent Oncology 3Health News:US Oncology Launches New Services Division: Innovent Oncology 4Health News:Exercise May Help Prevent Age-Related Memory Loss 2
(Date:7/30/2015)... VIEW, Calif. , July 30, 2015 ... it will release its second quarter 2015 financial results ... 2015.   In conjunction with the release, the Company ... at 5:00 p.m. Eastern Time on ... of the quarter and other business developments. ...
(Date:7/30/2015)... , July 30, 2015  Unichem Pharmaceuticals ( ... lot of Hydrochlorothiazide tablets 25 mg 1000-count bottle to ... a precautionary measure due to the identification of a ... The risk associated with mistakenly taking ... the increased probability of experiencing Clopidogrel,s side effects which ...
(Date:7/30/2015)... -- Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ) ... patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics ... notice it received on May 21, 2015 from the ... was below certain of the Exchange,s continued listing standards, ... the NYSE MKT Company Guide, due to the delay ...
Breaking Medicine Technology:IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2
... KNSY ), today announced that it has entered into ... under which DSM has agreed to acquire all of the common ... a merger with a subsidiary of DSM, for $38.50 per share ... entered into the merger agreement with DSM, as the transaction will ...
... Synteract , Inc., a full-service contract research organization ... therapies to combat the growing issue of antibiotic resistance, ... fundraising walk to benefit the Cystic Fibrosis (CF) ... behalf of Aptalis Pharma) are also working together on ...
Cached Medicine Technology:Kensey Nash Agrees to Be Acquired by DSM for $38.50 per Share in Cash 2Kensey Nash Agrees to Be Acquired by DSM for $38.50 per Share in Cash 3Kensey Nash Agrees to Be Acquired by DSM for $38.50 per Share in Cash 4Kensey Nash Agrees to Be Acquired by DSM for $38.50 per Share in Cash 5Kensey Nash Agrees to Be Acquired by DSM for $38.50 per Share in Cash 6Synteract and Rempex Partner in "Great Strides" Walk to Support Cystic Fibrosis Cure 2
Straight shafts with 16 mm long platform. Lengthwise serrated jaws with cross serrated tips. Serrated handle with polished finish. Platform: 2.4 mm wide....
Straight shafts with fitted v-grooved 15 mm platform. Serrated handle with polished finish....
Smooth tip forceps allow the surgeon to manipulate and smooth the corneal flap in Lasik procedures. Tip angled 10 mm from tip. Manufactured in titanium....
Straight shafts with 1 x 2 teeth. Flat handle with haoles and polished finish. Delicate teeth. Most popular size or model....
Medicine Products: