Navigation Links
How cancer cells rewire their metabolism to survive
Date:1/31/2013

LA JOLLA, Calif., January 31, 2013 Cancer cells need food to survive and grow. They're very good at getting it, too, even when nutrients are scarce. Many scientists have tried killing cancer cells by taking away their favorite food, a sugar called glucose. Unfortunately, this treatment approach not only fails to work, it backfiresglucose-starved tumors actually get more aggressive. In a study published January 31 in the journal Cell, researchers at Sanford-Burnham Medical Research Institute discovered that a protein called PKCζ is responsible for this paradox. The research suggests that glucose depletion therapies might work against tumors as long as the cancer cells are producing PKCζ.

PKCζ: critical regulator of tumor metabolism

According to this study, when PKCζ is missing from cancer cells, tumors are able to use alternative nutrients. What's more, the lower the PKCζ levels, the more aggressive the tumor.

"We found an interesting correlation in colon cancersif a patient's tumor doesn't produce PKCζ, he has a poorer prognosis than a similar patient with the protein. We looked specifically at colon cancer in this study, but it's likely also true for other tumor types," said Jorge Moscat, Ph.D., a professor in Sanford-Burnham's National Cancer Institute-designated Cancer Center. Moscat led the study in close collaboration with Sanford-Burnham colleague Maria Diaz-Meco, Ph.D.

PKCζ keeps tumors addicted to glucose, and under control

Although most cancer cells love glucose, tumors lacking PKCζ grow even better in the absence of this nutrient. Using human tumor samples and a mouse model of colon cancer, Moscat and his team determined this growth-without-glucose paradox is because PKCζ-deficient tumors are able to reprogram their metabolism to use glutamine, another nutrient, instead.

Without PKCζ around to keep them addicted to glucose, these tumors kick-start a new metabolic pathway. This altered metabolism helps PKCζ-deficient cancer cells survive in conditions that would otherwise be lethal.

"If we can find an effective way to add PKCζ back to tumors that lack it, we'd make them less suited for survival and more sensitive to current therapies," Moscat said.


'/>"/>

Contact: Heather Buschman
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Related medicine news :

1. Time spent watching television is not associated with death among breast cancer survivors
2. A new mechanism that contributes to the evolution of cancer
3. UCI team finds new target for treating wide spectrum of cancers
4. Side Effects of Prostate Cancer Treatments Similar in Long Run: Study
5. Prostate cancer study tracks long-term urinary, sexual and bowel function side effects
6. Silibinin, found in milk thistle, protects against UV-induced skin cancer
7. New target to stop cancers spread discovered by Georgia State scientists
8. US Drug Watchdog Now Urges Family Members Of Diabetics Who Used the Diabetes Drug Actos and Then Were Diagnosed with Bladder Cancer to Call The Johnson Law Group ASAP
9. Breast Cancer Gene May Be Tied to Early Menopause
10. Preclinical study identifies master proto-oncogene that regulates ovarian cancer metastasis
11. Study reveals 2-fold higher incidence of non-melanoma skin cancers for HIV patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How cancer cells rewire their metabolism to survive
(Date:1/23/2017)... Los Angeles, California (PRWEB) , ... January 23, 2017 , ... ... “Golden Era” principles, has added Mr. Olympia Classic Physique bodybuilder Breon Ansley to its ... back began competing as a bodybuilder in 2012 and in less than a year ...
(Date:1/23/2017)... ... ... a story of love and redemption, hope and uncertainty as a girl makes her ... Inn at the Mill” is the creation of published author, Lois Kulp, who was born ... Berks County on Crow Hill. The inn, the mill and "Post Yokel" are ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Life Under Blankets”: an ... an early age. “Life Under Blankets” is the creation of published author, Kimberly Mitchell, ... Campus in Chicago. She went on to pursue a master’s degree in education in ...
(Date:1/22/2017)... ... January 22, 2017 , ... Phytocéane invites clients to take an exotic ... the world with ZANZIBAR MILKY CREAM. Inspired by the beauty of Zanzibar, a Tanzanian ... Oil and moisturizing vegetal coral to create this gentle, velvety body cream to envelop ...
(Date:1/22/2017)... ... January 22, 2017 , ... Medical lab testing through hospitals and ... a simple test will take days to arrive to the end customer, having to ... access to their lab tests, bypassing the cost and delay of traditional means. Now ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... , January 23, 2017 Longer life expectancy and ... the global market for medical device technologies. BCC Research reveals ... Asia-Pacific region, should see strong growth due to ... disposable incomes. Continue Reading ... ...
(Date:1/23/2017)... 2017 NeuroVive Pharmaceutical AB (Nasdaq Stockholm: ... preclinical collaboration agreement with the Children,s Hospital of ... M.D., a US key opinion leader in the mitochondrial medicine ... ... from NeuroVive,s research program, NVP015, in certain experimental disease models. ...
(Date:1/21/2017)... 20, 2017 ResMed (NYSE: RMD ), BMC ... Winter Haven, Florida ) today announced they have agreed on ... 3B will be permitted to sell their existing products in exchange ... settlement payment to 3B to close the Florida ... an admission of liability or wrongdoing by any party. ...
Breaking Medicine Technology: