Navigation Links
How cancer cells rewire their metabolism to survive
Date:1/31/2013

LA JOLLA, Calif., January 31, 2013 Cancer cells need food to survive and grow. They're very good at getting it, too, even when nutrients are scarce. Many scientists have tried killing cancer cells by taking away their favorite food, a sugar called glucose. Unfortunately, this treatment approach not only fails to work, it backfiresglucose-starved tumors actually get more aggressive. In a study published January 31 in the journal Cell, researchers at Sanford-Burnham Medical Research Institute discovered that a protein called PKCζ is responsible for this paradox. The research suggests that glucose depletion therapies might work against tumors as long as the cancer cells are producing PKCζ.

PKCζ: critical regulator of tumor metabolism

According to this study, when PKCζ is missing from cancer cells, tumors are able to use alternative nutrients. What's more, the lower the PKCζ levels, the more aggressive the tumor.

"We found an interesting correlation in colon cancersif a patient's tumor doesn't produce PKCζ, he has a poorer prognosis than a similar patient with the protein. We looked specifically at colon cancer in this study, but it's likely also true for other tumor types," said Jorge Moscat, Ph.D., a professor in Sanford-Burnham's National Cancer Institute-designated Cancer Center. Moscat led the study in close collaboration with Sanford-Burnham colleague Maria Diaz-Meco, Ph.D.

PKCζ keeps tumors addicted to glucose, and under control

Although most cancer cells love glucose, tumors lacking PKCζ grow even better in the absence of this nutrient. Using human tumor samples and a mouse model of colon cancer, Moscat and his team determined this growth-without-glucose paradox is because PKCζ-deficient tumors are able to reprogram their metabolism to use glutamine, another nutrient, instead.

Without PKCζ around to keep them addicted to glucos
'/>"/>

Contact: Heather Buschman
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Time spent watching television is not associated with death among breast cancer survivors
2. A new mechanism that contributes to the evolution of cancer
3. UCI team finds new target for treating wide spectrum of cancers
4. Side Effects of Prostate Cancer Treatments Similar in Long Run: Study
5. Prostate cancer study tracks long-term urinary, sexual and bowel function side effects
6. Silibinin, found in milk thistle, protects against UV-induced skin cancer
7. New target to stop cancers spread discovered by Georgia State scientists
8. US Drug Watchdog Now Urges Family Members Of Diabetics Who Used the Diabetes Drug Actos and Then Were Diagnosed with Bladder Cancer to Call The Johnson Law Group ASAP
9. Breast Cancer Gene May Be Tied to Early Menopause
10. Preclinical study identifies master proto-oncogene that regulates ovarian cancer metastasis
11. Study reveals 2-fold higher incidence of non-melanoma skin cancers for HIV patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How cancer cells rewire their metabolism to survive
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... may lead to increased blood pressure, according to a new ... in blood pressure for young adult women or for teenagers, ... drank lightly or moderately, their risk of high blood pressure ... parallels studies in older adult men and women," said lead ...
(Date:10/22/2014)... taken by Firestone officials at the company,s rubber ... spread of the disease there and could prove effective ... provides health services to about 80,000 employees, retirees, their ... Between Aug. 1 and Sept. 23, there were 71 ... That incidence rate of 0.09 percent was much lower ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 ... while working for NBC News in Liberia has cleared ... unit at Nebraska Medical Center in Omaha, where he had been ... A blood test confirmed by the U.S. Centers for Disease Control ... Providence, R.I., NBC News reported Tuesday night. "Recovering ...
(Date:10/20/2014)... 20, 2014 With a mere 19 ... Crist made a brief fundraising stop at the ... , Fresh from a debate last night with his ... stage for the first seven minutes because Crist had ... described the incident in one word: "weird." , Before ...
(Date:10/20/2014)... Wakefield, MA (PRWEB) October 20, 2014 ... be sponsoring a booth at the American Foundation for ... October 25th. The AFSP is a not-for-profit organization that ... year. Net proceeds from these events are used to ... research, but education and personal relationships as well. ...
Breaking Medicine News(10 mins):Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3
... Jenifer Goodwin HealthDay Reporter , THURSDAY, Aug.5 ... village, shrapnel sliced into a 5-year-old girl,s skull, almost ... to a hospital at Bagram Airfield, where a U.S. ... priority of military surgeons is treating injured U.S. servicemen ...
... to find, here,s good news for the under-qualified: A ... ( http://www.fasebj.org ) shows that being a highly cited ... on leading management positions at research institutions. This study ... exist at research institutions where top-cited scientists either do ...
... injury for both urban and rural elderly in China, responsible ... and older, according to a new study by researchers from ... Center for Injury Research and Policy. This is the first ... older adults in China, who make up 9 percent of ...
... for-profit insurance company approved to offer government-subsidized coverage ... to primary care, according to data reported in ... Medicine . Researchers say the findings raise troubling ... which is modeled after the Massachusetts plan. ...
... Kathleen Doheny HealthDay Reporter , WEDNESDAY, Aug. 4 ... as ferroportin are tied to recurrent, aggressive breast cancers, new ... iron from cells, may someday help doctors better predict which ... the researchers say. "We had a hint that ...
... Aug. 4, 2010 The Harold C. Simmons ... attained National Cancer Institute (NCI) designation, an elite distinction ... The Simmons Cancer Center is the first medical center ... the NCI bestows upon the nation,s top cancer centers ...
Cached Medicine News:Health News:U.S. Military Surgeons Saving Children's Lives in Afghanistan 2Health News:U.S. Military Surgeons Saving Children's Lives in Afghanistan 3Health News:Help wanted: Highly cited researchers needed for high-ranking positions at research institutions 2Health News:Falls the leading cause of injury among older adults in China 2Health News:Doctors hard to find for patients in Massachusetts' first for-profit health plan 2Health News:Doctors hard to find for patients in Massachusetts' first for-profit health plan 3Health News:A New Marker to Spot Aggressive Breast Cancers? 2Health News:UT Southwestern's cancer center earns National Cancer Institute designation 2Health News:UT Southwestern's cancer center earns National Cancer Institute designation 3
(Date:10/22/2014)... 2014 Influenza will affect as many as 200,000 ... the United States as high as 49,000 people.  ... is from person to person in respiratory droplets of coughs ... of death, but kills much fewer people each year than ... human fluids including sweat, saliva, blood and other bodily fluids. ...
(Date:10/22/2014)... and AUSTIN, Texas , ... PureMHC LLC today announced they have entered into ... antibody-based immunotherapies designed to target cancers. ... peptides displayed on the surfaces of tumor cells ... targets (PTTs), derived from proteins that play a ...
(Date:10/22/2014)... SHANGHAI , Oct. 22, 2014   ... and WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... comprehensive genomic profiling to biopharmaceutical companies conducting clinical trials ... Under the terms of the collaboration, Foundation Medicine will ... of Foundation Medicine,s FoundationOne® assay at the WuXi Genome ...
Breaking Medicine Technology:WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2Biotech Companies To Co-Discover And Co-Develop Antibodies Targeting Novel Phosphopeptide Tumor Targets 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 3Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 4Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 5
... and VEDBAEK, Denmark, Dec. 22 AdvanDx today announced that it ... for its E. coli / P. aeruginosa PNA FISH® ... protocol reduces the PNA FISH turn-around time from the original 2.5 ... minutes to 30 minutes. Clinical validation studies performed at hospitals ...
... , , NEW YORK, Dec. 22 ... company testing its proprietary treatment method for primary and metastatic ... has joined the Company,s Scientific Advisory Board, effective immediately. ... advance the development of our Delcath PHP System(TM) with insight ...
Cached Medicine Technology:AdvanDx Receives FDA 510(k) Clearance for 90 Minutes PNA FISH(R) Protocol for Identifying Gram-Negative Bloodstream Pathogens 2AdvanDx Receives FDA 510(k) Clearance for 90 Minutes PNA FISH(R) Protocol for Identifying Gram-Negative Bloodstream Pathogens 3Professor Riccardo Lencioni Joins Delcath Systems' Scientific Advisory Board 2Professor Riccardo Lencioni Joins Delcath Systems' Scientific Advisory Board 3
Hudson Drill hand drill....
Hudson Brace, snap lock chuck....
Binocular operation microscope with innovative mechanism for smooth operation....
... has pioneered the development of ... system, an innovative solution that ... efficient and less invasive. The ... the OME-7000 surgical microscope, the ...
Medicine Products: