Navigation Links
How cancer cells rewire their metabolism to survive
Date:1/31/2013

LA JOLLA, Calif., January 31, 2013 Cancer cells need food to survive and grow. They're very good at getting it, too, even when nutrients are scarce. Many scientists have tried killing cancer cells by taking away their favorite food, a sugar called glucose. Unfortunately, this treatment approach not only fails to work, it backfiresglucose-starved tumors actually get more aggressive. In a study published January 31 in the journal Cell, researchers at Sanford-Burnham Medical Research Institute discovered that a protein called PKCζ is responsible for this paradox. The research suggests that glucose depletion therapies might work against tumors as long as the cancer cells are producing PKCζ.

PKCζ: critical regulator of tumor metabolism

According to this study, when PKCζ is missing from cancer cells, tumors are able to use alternative nutrients. What's more, the lower the PKCζ levels, the more aggressive the tumor.

"We found an interesting correlation in colon cancersif a patient's tumor doesn't produce PKCζ, he has a poorer prognosis than a similar patient with the protein. We looked specifically at colon cancer in this study, but it's likely also true for other tumor types," said Jorge Moscat, Ph.D., a professor in Sanford-Burnham's National Cancer Institute-designated Cancer Center. Moscat led the study in close collaboration with Sanford-Burnham colleague Maria Diaz-Meco, Ph.D.

PKCζ keeps tumors addicted to glucose, and under control

Although most cancer cells love glucose, tumors lacking PKCζ grow even better in the absence of this nutrient. Using human tumor samples and a mouse model of colon cancer, Moscat and his team determined this growth-without-glucose paradox is because PKCζ-deficient tumors are able to reprogram their metabolism to use glutamine, another nutrient, instead.

Without PKCζ around to keep them addicted to glucos
'/>"/>

Contact: Heather Buschman
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Time spent watching television is not associated with death among breast cancer survivors
2. A new mechanism that contributes to the evolution of cancer
3. UCI team finds new target for treating wide spectrum of cancers
4. Side Effects of Prostate Cancer Treatments Similar in Long Run: Study
5. Prostate cancer study tracks long-term urinary, sexual and bowel function side effects
6. Silibinin, found in milk thistle, protects against UV-induced skin cancer
7. New target to stop cancers spread discovered by Georgia State scientists
8. US Drug Watchdog Now Urges Family Members Of Diabetics Who Used the Diabetes Drug Actos and Then Were Diagnosed with Bladder Cancer to Call The Johnson Law Group ASAP
9. Breast Cancer Gene May Be Tied to Early Menopause
10. Preclinical study identifies master proto-oncogene that regulates ovarian cancer metastasis
11. Study reveals 2-fold higher incidence of non-melanoma skin cancers for HIV patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How cancer cells rewire their metabolism to survive
(Date:8/28/2014)... 2014 Following the death of an 18-year-old ... FDA issued a warning on powdered caffeine products. ... substance that is readily available to consumers, despite the fact ... senior Logan Stiner died from an overdose of caffeine powder. ... the FDA to issue a safety advisory for caffeine powders. ...
(Date:8/28/2014)... 28, 2014 Catalent Pharma Solutions, ... and development solutions for drugs, biologics and consumer ... Director Clinical Supply Services, and Chris Greco, Manager, ... Sourcing Strategies for Active Control Clinical Trials” at ... takes place on the 9th – 10th September, ...
(Date:8/28/2014)... 2014) A subset of patients with stage III ... irinotecan-based therapy, according to a new study in ... of the American Gastroenterological Association. , When added to ... adjuvant irinotecan therapy improved overall survival rates for patients ... seen in about 10 to 20 percent of colorectal ...
(Date:8/28/2014)... scientists are working out how to safely increase the ... offering improved local control and survival. , Standard treatment ... combination of radiotherapy and chemotherapy. Traditionally this is planned ... not always be enough to stop tumour growth. , ... cancerous tissue varies between patients and depends on the ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 AmeriPride Services, ... America, today announced the launch of its new Customer ... AmeriPride even easier and more convenient for customers. The ... online and better communicate with the company. , Features ... Access, download and pay bills ...
Breaking Medicine News(10 mins):Health News:FDA Issues Safety Advisory for Caffeine Powders 2Health News:Critical Path Sourcing Strategies for Global Clinical Trials Presented by Catalent Experts at US Clinical Trials Supply Conference 2Health News:Drug shows promise for subset of stage III colon cancer patients 2Health News:Research demonstrates potential method to better control lung cancer using radiotherapy 2Health News:AmeriPride Services Launches New Customer Portal 2Health News:AmeriPride Services Launches New Customer Portal 3
... researchers say , SUNDAY, Nov. 18 (HealthDay News) -- ... suggests. , A U.S. team found that talking to ... and test scores. , They found that "socializing was ... exercise in boosting memory and intellectual performance," lead author ...
... costs and prepare ... covers of hospital costs and, efficiencies using more refined performance metrics ... ... A new benchmarking study was,launched today to measure the cost and efficiencies of ...
... it from spreading, expert says , , SATURDAY, Nov. 17 (HealthDay News) ... hit by the flu bug this year, but some simple precautions ... said. , The flu shot is the most effective method of ... officer at Brigham and Women,s Hospital in Boston. It,s important to ...
... Nancy Pelosi,will join Congressmen Ciro D. Rodriguez, Charlie ... the State Children,s Health,Insurance Program (SCHIP) bill that ... WHO: Speaker Nancy Pelosi Congressman Ciro D. ... Congressman Henry Cuellar (TX-28), WHAT: Rally for ...
... Nov. 16 Angel Flight West,(AFW) awarded The Distinguished ... Dan Telfair at AFW,s 24th Anniversary Awards and on ... awards event. Telfair,completed 56 missions over the past year. ... non-emergency health care problems require that they travel,to and ...
... Nov. 16 Nothing says,"Thanksgiving" like football, family and ... But no matter what,s included in a,Thanksgiving spread, one ... the American Society for Surgery of the Hand cautions,carvers ... not their own hands., Every year during Thanksgiving, ...
Cached Medicine News:Health News:Talking With Others May Make You Smarter 2Health News:Global Health Support Service Benchmark Study to Combat Growing Healthcare Costs and Prepare for Likely Health Care Reforms 2Health News:Angel Flight West Recognizes New Mexico Pilots and Receives Grant to Improve Access to Health Care 2Health News:Holiday Hand Safety 101: Hand Surgeons Offer Tips for a Safe Carving Season 2
(Date:8/28/2014)... Aug. 28, 2014  A decline in revenues ... are adding pressure to pharmaceutical, biotechnology and medical ... continue to shrink and approval processes and postapproval ... companies to look for additional support and expertise ... keeping approved products on the market.  ...
(Date:8/28/2014)... VIEJO , Californie, 28 août ... a annoncé aujourd,hui le début des ... d,une étude  d,exemption des dispositifs expérimentaux ... destinée à évaluer l,innocuité et l,efficacité ... (« WEB »). Le docteur Adam Arthur ...
(Date:8/28/2014)... , Aug. 28, 2014  Celsion Corporation (NASDAQ: ... company, today announced that Michael H. Tardugno , ... at the Rodman & Renshaw 16th Annual Healthcare Conference ... a.m. Eastern Time. The conference is being held at ... A copy of the presentation will be available on ...
Breaking Medicine Technology:4 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 24 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 34 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 4Sequent Medical annonce le démarrage d'une étude IDE pour le système WEB d'embolisation des anévrismes 2Sequent Medical annonce le démarrage d'une étude IDE pour le système WEB d'embolisation des anévrismes 3Sequent Medical annonce le démarrage d'une étude IDE pour le système WEB d'embolisation des anévrismes 4Celsion to Present at the Rodman & Renshaw 16th Annual Healthcare Conference 2
... Abaxis, Inc. (NasdaqGS: ABAX), a medical products company manufacturing ... chief operations officer, will present at ThinkEquity,s Second Annual ... a.m. ET. The conference will be held at The ... About AbaxisAbaxis develops, manufactures, markets and sells portable blood ...
... presented this week at the International Federation of Clinical ... lower diagnostic threshold for troponin improves clinical outcomes and ...  Troponin is a protein found inside of heart cells ... or reduced blood supply.   Cardiac troponin ...
Cached Medicine Technology:Study Shows Improved Patient Management and Outcome Using Abbott's Sensitive Troponin Assay 2Study Shows Improved Patient Management and Outcome Using Abbott's Sensitive Troponin Assay 3Study Shows Improved Patient Management and Outcome Using Abbott's Sensitive Troponin Assay 4
For Atrial Mapping. Biosense Webster offers a complete line of specialty 20-pole catheters. The CRISTA CATH 20-pole deflectable catheter is designed for positioning along the crista terminals....
... Inquiry H Steerable Catheter. Steerable ... variety of designs and a ... stability. 10 to 24 electrodes, ... inactive and active tip electrodes, ...
Sophisticated DecaPolar Catheters provide enhanced recording and mapping quality....
... Torqr Quadripolar Braided Shaft ... The Medtronic CardioRhythm Torqr ... use in diagnostic electrophysiologic ... designed for recording intracardiac ...
Medicine Products: