Navigation Links
How cancer cells loose their (Circadian) rhythm
Date:5/10/2010

sms to humans peaks at specific times of the day and consider this as indirect evidence that the process is regulated by their internal biological clocks. Cells in the human mouth, for example, tend to divide in the evening, just before nightfall.

"There is a general evolutionary explanation for this," says research associate Julie Pendergast who participated in the study. "Ultraviolet light is one of the primary causes of mutations. Cells are particularly vulnerable to mutations during cell division. So organisms with cells that divide at night have a selective advantage."

In addition, there has been a considerable amount of indirect evidence that mitosis (division) in cancer cells is not under 24-hour control. For example, "experiments have found that cells turn cancerous when certain circadian clock genes have been knocked out," says Yamazaki. The results of other experiments that have periodically sampled cancer cell division rates also support this possibility.

Yamazaki designed and built a special system to monitor cell division in real time. He and his colleagues designed a special "reporter" molecule incorporating a gene that produces an enzyme that makes green light. They figured out how to insert this reporter into a cell's genome so that it produces the luminescent enzyme when the cell divides. This allows them to use a camera to continuously measure variations in the rate of cell division over long periods of time.

For the current experiment, the researchers inserted their special reporter into immortalized rat fibroblasts formed from connective tissue taken from rats. They selected this cell line because it was known to have working circadian clocks.

They have obtained consistent results in preliminary studies of lung cancer cells.


'/>"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Researchers discover new way to rescue treatment sensitivity of breast cancer cells
2. U.S. Cancer Costs Double in Two Decades
3. Jenny McCarthy - Actress, Activist, and Model - Dedicates bforacure's ‘breasts are beautiful' to Help Raise Money for Breast Cancer Charities
4. Medical costs of cancer have nearly doubled over the past 2 decades
5. Kidney removal does not prolong the lives of elderly patients with localized kidney cancer
6. Coffee and soft drinks have little or no association with colon cancer risk
7. No Link Between Coffee, Sodas and Colon Cancer
8. Tumor Cells in Blood Affect Breast Cancer Survival
9. Cancer Society Says U.S. Report Failed to Prove Health Risks
10. Simple Test May Identify Breast Cancer Subtypes
11. Interesting stories at the IMPAKT Breast Cancer Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How cancer cells loose their (Circadian) rhythm
(Date:11/27/2014)... In order to enable people to adapt to ... easy way to avoid touching a toilet seat and/or lid ... prototype of the patent-pending Toilet Tamer, a device that enables ... lid in a more sanitary manner. It avoids direct contact ... it promotes good hygiene and peace of mind. The portable ...
(Date:11/27/2014)... Now that Thanksgiving is finally here ... Emassagechair.com has announced its eagerly awaited, once ... , Negotiating on behalf of their customers, and drawing ... Emassagechair.com has generated significant buzz in the industry with ... yet. , Shoppers are excited for significant savings available ...
(Date:11/27/2014)... 27, 2014 VogueQueen.com is making every ... ladies across the world. As the premier online supplier ... is proud to release a huge selection of sexy ... outfits, it is also providing many beautiful styles in ... gowns at discounted prices. , “VogueQueen.com hopes to ...
(Date:11/27/2014)... 27, 2014 Developers and plugin specialist of ... entitled ProPip, taking FCPX to the next level. , “ProPip ... a few clicks of a mouse,” said Christina Austin, CEO ... our users will appreciate.” , With ProPip users can show ... possibilities truly endless. ProPip is great for commentaries, news casting, ...
(Date:11/27/2014)... HealthPostures, a leading national designer ... announced that it has entered into a new ... will put HealthPostures' products into central Indiana’s premiere ... to having its products sold through Commercial Office ... with the business decision makers in the Indianapolis ...
Breaking Medicine News(10 mins):Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 2Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 3Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 4Health News:A New Collection of Sexy Prom Dresses Has Been Released by the Reliable Online Supplier VogueQueen.com 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 3Health News:Ergonomics Manufacturer Announces New Partnership with Office Supply Dealer 2
... Millions of postmenopausal women suffer from sexual dysfunctions- ... physiological and psychological problems. ,However if the ... these problems can be treated properly. Almost all ... develop changes in genital organs-particularly a condition known ...
... breast lumps are too small to be picked up by ... a potential candidate for breast cancer. But to offset this ... Baltimore headed by Dr. Saraswathi Sukumar, have devised a new ... a new method called ductal lavage. Ductal lavage, involves "washing" ...
... with diabetes, the most painful and bothering one is the ... part according to many diabetics is the finger stick. There ... times a day for more than ten to twenty years ... pain and discomfort associated with them. But researchers and manufacturers ...
... of Anti-dumping and Allied Duties, under the ministry ... duties on paracetamol from China and Taiwan. This ... used drug on basis of a petition filed ... and Sri Krishna Pharmaceuticals; Solapur based Vamsi Labs, ...
... therapy, complimentary and alternative medicine seem to be more ... new study. Among 191 HIV-positive outpatients surveyed about their ... had used alternative therapies at some point to control ... findings appear in the current issue of The journal ...
... wound healing in depressed people is four times slower than ... place in the latest issue of the journal, “Psychosomatic Medicine”. ... the rate of wound healing, according to the researchers. Depression ... immune system, which may keep a wound from healing on ...
Cached Medicine News:
(Date:11/26/2014)... JOLLA, Calif. , Nov. 26, 2014   ... a biopharmaceutical company leading the discovery and development of ... G. Xanthopoulos , Ph.D., President and CEO of Regulus, ... Annual Piper Jaffray Healthcare Conference at the New ... 2:00 p.m. EST.  The presentation will be webcast at ...
(Date:11/26/2014)... ® , Inc. (NASDAQ: BIOS ) announced today that ... present at the Bank of America Merrill Lynch 2014 Leveraged Finance ... , , Wednesday, December 3, 2014 , , , , ... , Location: , , , Boca Raton Resort and Club, Florida ... BioScrip, Inc. is a leading national provider of infusion ...
(Date:11/26/2014)... 26, 2014 The medical magnetic resonance ... of 4%, with world market revenues for 2013 ... and other types of medical imaging have led ... numerous medical conditions in children and adults, each ... report, Medical Imaging Markets , analyzes the ...
Breaking Medicine Technology:Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 2Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 3Kalorama: Steady Growth in the Medical MRI Market 2Kalorama: Steady Growth in the Medical MRI Market 3
... ... of Body Mass Index -, PHILADELPHIA, Oct. 16 ... been,established, but healthcare professionals have had little guidance as to,whether ... with GERD. Two studies about obesity and its,relationship to GERD ...
... to File Supplemental New Drug Application with FDA in First ... ... FRANCISCO, Calif., Oct. 16 Anesiva,Inc. (Nasdaq: ANSV ) today ... randomized, double-blind study,with 699 adult patients met its primary endpoint, demonstrating ...
Cached Medicine Technology:Studies Show Body Mass Index Has No Effect on Resolution and Healing of GERD Symptoms 2Studies Show Body Mass Index Has No Effect on Resolution and Healing of GERD Symptoms 3Studies Show Body Mass Index Has No Effect on Resolution and Healing of GERD Symptoms 4Studies Show Body Mass Index Has No Effect on Resolution and Healing of GERD Symptoms 5Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults 2Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults 3Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults 4Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: