Navigation Links
How breast cancer cells evade therapeutic attacks
Date:3/31/2010

Tumour cells depend upon estrogens to survive and proliferate in about 70% of all breast cancer cases. The most frequently used treatment to fight this variety of tumours relies on anti-estrogens such as tamoxifen. However, resistance to this type of therapy develops in more than 30% of the patients. Understanding the mechanisms involved in the appearance of resistance to tamoxifen is thus essential to develop new therapeutic approaches. The research done by the team of Didier Picard, professor at the University of Geneva (UNIGE), provides key answers in the 1st of April 2010 edition of Genes & Development. Their study reveals how cancer cells become impervious to the drug by activating a specific biochemical cascade. The latter, normally triggered by a chemical messenger called cyclic AMP, is permanently stimulated in cells refractory to the treatment.

Breast cancer, which is characterized by an enhanced and anarchic proliferation of mammary cells, is one of the main causes of cancer-related mortality in women. In over two thirds of the cases, estrogens play an active part in the progression of the disease, due to the presence of receptors for this hormone in the nucleus of malignant cells. Estrogens indeed modulate the expression of genes necessary to cell survival and proliferation through their interaction with these receptors.

The most frequent treatment for this type of breast cancer, called hormone-dependent, relies on anti-estrogens such as tamoxifen, which block tumour cell growth by inhibiting the activity of the receptor. However, the cancer eventually becomes resistant to the therapy in more than 30% of the patients.

The second messenger's key role

"Estrogen receptors, notably the one called ERα, are also activated by other molecules that operate in an indirect way, without interacting with them", explains Didier Picard, professor at the Faculty of Sciences of UNIGE. "We aim precisely at understandin
'/>"/>

Contact: Laura Pizurki
Lara.Pizurki@unige.ch
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Breast Cancer Survivor Tackles the Missing Link: Inspiring Event Offers Women Real Life Advice to Thrive After Medical Treatment Ends
2. Simple Forms Help Docs Do Better Breast Exams
3. The Global Summit on International Breast Health
4. Epione Laser Breast Lift Poised to Lead Breast Enhancement Trends
5. Clues to pregnancy-associated breast cancer found
6. Rubicon Medical To Offer Allergan Implants In Breast Enlargement Surgery
7. Specific lymph node radiotherapy is well tolerated after surgery in early breast cancer patients
8. Protein in Breast Tumors May Predict Chemo Response
9. Many With Breast Cancer Decide Too Soon to Remove Other Breast
10. Long-Term Breast-Feeding Tied to More Aggressive Cancers
11. Beta Blockers May Slow Spread of Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Washington, DC (PRWEB) August 27, 2014 ... Inc.’s Diplomat University were announced as the winners ... August issue of Atlantic Information Services, ... article penned by the company’s founder and Principal ... companies were commended for meeting the true definition ...
(Date:8/27/2014)... Top10BestSEOHosting.com compares many popular hosting suppliers and ... recommended suppliers for webmasters who want to buy ... GoDaddy provide stellar hosting products and services for ... to provide a wide range of advanced features ... that helps diminish the inherent complexity and learning ...
(Date:8/27/2014)... and Ontario, Canada (PRWEB) August 27, 2014 ... through a huge transformation as was revealed in a ... 2014 survey were not just surprising but astonishing as ... survey carried out online interviewed existing members on the ... Facebook. , According to Kaly, 10yeargap marketing department manager," ...
(Date:8/27/2014)... Discover Leadership Training is the foremost expert in ... comprehensive leadership programs. As the Vice President of Discover ... realm of outcome-focused and benefit-driven choices. Barb Moses is ... series titled, “A Women’s Guide to Making Her Life ... part webinar is titled, “My Current Story” which will ...
(Date:8/27/2014)... August 27, 2014 Overcoming a turbulent past ... found his niche. The Women’s Radio Network, WRNW1, has recently ... continued support and dedication to the WRNW1 family. KC states, ... have such a positive atmosphere.” After KC Armstrong publicly announced ... of the Howard Stern show, “Howard 100 News,” have decided ...
Breaking Medicine News(10 mins):Health News:Specialty Pharmacy Solutions Founder Reveals Winners of Innovation Competition in August Issue of AIS Newsletter 2Health News:Specialty Pharmacy Solutions Founder Reveals Winners of Innovation Competition in August Issue of AIS Newsletter 3Health News:Excellent Hosting Suppliers Recommended By Top10BestSEOHosting.com 2Health News:Survey Reveals Younger Women Dating Older Men 2Health News:Survey Reveals Younger Women Dating Older Men 3Health News:Barb Moses, Vice President of Discover Leadership Training, Announces New Webinar Titled, “A Women’s Guide to Making Her Life Story a Bestseller” 2Health News:The Women's Radio Network, WRNW1, Signs KC Armstrong to a Multi-Million Dollar Contract 2
... Group, Inc. (NYSE Amex: QGP ) ( ... Stock Transfer and Trust Company to act as Transfer Agent ... CEO, commented, "Continental Stock Transfer has been in business for ... as a comprehensive and customer-centric company that can facilitate the ...
... NETworks to get on the map. , ... Washington, ... a worldwide fundraiser challenge today to raise money to send lifesaving ... number one killer of refugees. Supporters are holding hundreds of fundraisers ...
... leading provider of strategic workforce management consulting and implementation services, ... to accommodate the firm,s growing base of healthcare clients striving to ... advanced workforce management solutions. , ... Denver, CO (PRWEB) ...
... holiday fast approaching, tons of chocolate will soon be consumed. Dr. Dave ... chocolate and which is healthier for you. , ... (PRWEB) March 31, ... Easter Bunnies are unleashed on the world; given as sweet treats for ...
... Helps Determine Benefits Included in a New Law and Manages Applicants, ... Company (NYSE: IBM ), today announced that ... Castilla y Leon region in Spain, will be helping its citizens ... through the use of a new system built around IBM ILOG ...
... N.C. A recent discovery by researchers at Wake Forest ... new drug that inhibits tumor growth in cancer patients and ... discovery stems from a study, recently published in the ... United States of America, in which researchers looked at angiogenesis ...
Cached Medicine News:Health News:The Quantum Group Announces Transition to Continental Stock Transfer 2Health News:The Quantum Group Announces Transition to Continental Stock Transfer 3Health News:Nothing But Nets Launches World Malaria Day Fundraising Challenge 2Health News:Nothing But Nets Launches World Malaria Day Fundraising Challenge 3Health News:Director of Healthcare Solutions Appointed to Guide Workforce Management Initiatives for Hospitals and Long Term Care Facilities 2Health News:Director of Healthcare Solutions Appointed to Guide Workforce Management Initiatives for Hospitals and Long Term Care Facilities 3Health News:Poison Dressed as an Easter Bunny 2Health News:Spain's Junta De Castilla y Leon Streamlines Benefits Delivery for Dependent Care With IBM ILOG JRules 2Health News:Blood protein may hold key to stopping tumor growth in cancer patients 2
(Date:8/26/2014)... 2014  Actavis plc (NYSE: ACT ), a ... Saunders , CEO and President of Actavis, will provide an ... Stanley Global Healthcare Conference 2014 in New York, ... The presentation will take place on Tuesday, September ... Hyatt New York, 109 East 42 nd Street, ...
(Date:8/26/2014)... Research and Markets  has announced the ... 2014-2018" report to their offering. Intranasal ... the administration of drugs for the treatment of local ... allergic and non-allergic rhinitis and sinusitis. The nose is ... vaccination and systematic drug delivery. Continuous ...
(Date:8/26/2014)... comes to diabetes supplies, innovations are often accused of ... answer a real medical need. Fitting ... shows how long it,s been since your last injection. ... insulin doses. Very easy to use, Timesulin starts automatically ... after an injection. There is no settings or complicated ...
Breaking Medicine Technology:Actavis to Present at Morgan Stanley Global Healthcare Conference 2014 2Global Intranasal Drug Delivery Market 2014-2018: Key Vendors are Becton, Dickinson and Company, GlaxoSmithKline, Johnson & Johnson and Novartis 2Global Intranasal Drug Delivery Market 2014-2018: Key Vendors are Becton, Dickinson and Company, GlaxoSmithKline, Johnson & Johnson and Novartis 3Montméd obtains reimbursement of Timesulin, the smart insulin pen timer cap, by major insurance companies in Canada 2
... The 1000 plate capacity MG-1000 ... workstations. Two people working side by ... in those labs that need it. ... colony counter inside for real-time growth ...
... is the most versatile orthopedic/trauma ... designed for both lower body ... an integrated shoulder attachment. The ... operating table for your most ...
... 1700 Series Outpatient Surgical Table is built ... Skytron's other specialty and general purpose surgical ... features such as 180-degree top rotation for ... side rails will accommodate a wide variety ...
... The schaerer axis ... been specially designed for ... maximum C-arm access. The ... possibilities and the offset ...
Medicine Products: