Navigation Links
How bacteria talk to each other and our cells
Date:11/6/2012

Bacteria can talk to each other via molecules they themselves produce. The phenomenon is called quorum sensing, and is important when an infection propagates. Now, researchers at Linkping University in Sweden are showing how bacteria control processes in human cells the same way.

The results are being published in the journal PLOS Pathogens with Elena Vikstrm, researcher in Medical Microbiology, as the main author.

When an infection is signaled, more and more bacteria gather at the site of the attack a wound, for example. When there are enough of them, they start acting like multicellular organisms. They can form biofilms, dense structures with powers of resistance against both antibiotics and the body's immune defence system. At the same time, they become more aggressive and increase their mobility. All these changes are triggered when the communication molecules short fatty acids with the designation AHL bind to receptors inside the bacterial cells; as a consequence various genes are turned on and off.

AHL can migrate freely through the cell membrane, not just in bacterial cells but also our own cells, which can be influenced to change their functions. In low concentrations white blood cells, for example, can be more flexible and effective, but in high concentrations the opposite occurs, which weakens our immune defences and opens the door for progressive infections and inflammations.

A team at Linkping University is the first research group in the world to show how AHL can influence their host cells. Using biochemical methods, the researchers have identified a protein designated IQGAP, which they single out as the recipient of the bacteria's message, and something of a double agent.

"The protein can both listen in on the bacteria's communication and change the functions in its host cells," Vikstrm says.

Their laboratory studies were carried out on human epithelial cells from the intestines, which were mixed with AHL of the same type produced by Pseudomonas aeruginosa, a tough bacterium that causes illnesses in places like the lungs, intestines, and eyes. With the help of mass spectrometry, they have been able to see which proteins bind AHL.

"We have proof that physical contact between bacteria and epithelial cells is not always required; the influence can happen at a distance," Vikstrm says.

The team's discovery can open the door to new strategies for treatment where antibiotics cannot help. One possibility is designing molecules that bind to the receptor and block the signal path for the bacteria something like putting a stick in a lock so the key won't go in. It's a strategy that could work with cystic fibrosis, for example, an illness where sticky mucus made of bacterial biofilm and large amounts of white blood cells is formed in the airways.


'/>"/>

Contact: Elena Vikstrm
elena.vikstrom@liu.se
46-010-103-2054
Linkping University
Source:Eurekalert

Related medicine news :

1. Pharmacy Robots Linked to Bacterial Contamination of Drugs
2. Children with juvenile arthritis have higher rates of bacterial infection
3. University of Minnesota startup to treat challenging bacterial infection
4. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
5. Zooming in on bacterial weapons in 3-D
6. Genomes show how Staph bacteria gain resistance to last-line drug
7. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
8. Killer stainless steel: New process gives icon of cleanliness antibacterial coating
9. Study Ties Kids Allergy Risks to Antibacterials, Preservatives
10. Rare Drug-Resistant Bacteria Spotted in U.S. Hospital
11. Eating garbage: Bacteria for bioremediation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... , ... Rob Lowe is a sought after actor, and also serves as ... public important topics from all aspects of life, and a new segment is being ... and ankles. , Podiatry is essential to people’s overall well-being, and if viewers have ...
(Date:5/24/2017)... , ... May 24, 2017 , ... ... fluoride (PVDF) based sleep diagnostics sensors, announced today it had completed the first ... of a mix of domestic and rest of world (ROW) authorized dealers specializing ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... medical device sectors, today announced the winners of its 3rd Annual ELITE Awards. ... most influential people in the healthcare industry today. , Out of more than ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... certification body for exercise professionals, is pleased to announce the organization’s Certified Strength ... , The NCSF Certified Strength Coach (CSC) program validates the competency of qualified ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... educating patients on peri-implantitis in Las Vegas, NV, and the importance ... custom gum disease consultation and leading care for peri-implantitis, with or without a ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... MACRA replaces the outdated sustainable growth ... reimbursement. Black Book Research crowdsource-surveyed 8,845 physician practices from ... Market for MIPS Compliance Technology is Booming ... 3 or more clinicians seek to buy Merit-Based Incentive ... magnitude of the changes, the hunt is on for ...
(Date:5/6/2017)... , May 5, 2017   Provista , a ... more than 200,000 customers, today announced Jim Cunniff ... wealth of executive and business experience to Provista, including most ... pharmacy in California . He assumed his ... "Jim is a great fit for Provista," says Jody ...
(Date:5/6/2017)... , May 5, 2017  Hill-Rom Holdings, Inc. (NYSE: ... approximately 100,000 square feet to its Welch Allyn campus. ... its commitment to bring more than 100 new jobs ... Welch Allyn has maintained a significant presence for more ... these new positions, a large portion of which will ...
Breaking Medicine Technology: