Navigation Links
How bacteria talk to each other and our cells
Date:11/6/2012

Bacteria can talk to each other via molecules they themselves produce. The phenomenon is called quorum sensing, and is important when an infection propagates. Now, researchers at Linkping University in Sweden are showing how bacteria control processes in human cells the same way.

The results are being published in the journal PLOS Pathogens with Elena Vikstrm, researcher in Medical Microbiology, as the main author.

When an infection is signaled, more and more bacteria gather at the site of the attack a wound, for example. When there are enough of them, they start acting like multicellular organisms. They can form biofilms, dense structures with powers of resistance against both antibiotics and the body's immune defence system. At the same time, they become more aggressive and increase their mobility. All these changes are triggered when the communication molecules short fatty acids with the designation AHL bind to receptors inside the bacterial cells; as a consequence various genes are turned on and off.

AHL can migrate freely through the cell membrane, not just in bacterial cells but also our own cells, which can be influenced to change their functions. In low concentrations white blood cells, for example, can be more flexible and effective, but in high concentrations the opposite occurs, which weakens our immune defences and opens the door for progressive infections and inflammations.

A team at Linkping University is the first research group in the world to show how AHL can influence their host cells. Using biochemical methods, the researchers have identified a protein designated IQGAP, which they single out as the recipient of the bacteria's message, and something of a double agent.

"The protein can both listen in on the bacteria's communication and change the functions in its host cells," Vikstrm says.

Their laboratory studies were carried out on human epithelial cells from the intestines, which were mixed with AHL of the same type produced by Pseudomonas aeruginosa, a tough bacterium that causes illnesses in places like the lungs, intestines, and eyes. With the help of mass spectrometry, they have been able to see which proteins bind AHL.

"We have proof that physical contact between bacteria and epithelial cells is not always required; the influence can happen at a distance," Vikstrm says.

The team's discovery can open the door to new strategies for treatment where antibiotics cannot help. One possibility is designing molecules that bind to the receptor and block the signal path for the bacteria something like putting a stick in a lock so the key won't go in. It's a strategy that could work with cystic fibrosis, for example, an illness where sticky mucus made of bacterial biofilm and large amounts of white blood cells is formed in the airways.


'/>"/>

Contact: Elena Vikstrm
elena.vikstrom@liu.se
46-010-103-2054
Linkping University
Source:Eurekalert

Related medicine news :

1. Pharmacy Robots Linked to Bacterial Contamination of Drugs
2. Children with juvenile arthritis have higher rates of bacterial infection
3. University of Minnesota startup to treat challenging bacterial infection
4. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
5. Zooming in on bacterial weapons in 3-D
6. Genomes show how Staph bacteria gain resistance to last-line drug
7. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
8. Killer stainless steel: New process gives icon of cleanliness antibacterial coating
9. Study Ties Kids Allergy Risks to Antibacterials, Preservatives
10. Rare Drug-Resistant Bacteria Spotted in U.S. Hospital
11. Eating garbage: Bacteria for bioremediation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... How physicians and athletic trainers ... say researchers presenting their work at the American Orthopaedic Society for Sports ... evaluating the patterns of change in concussion symptom presentation, diagnostic tools used and ...
(Date:7/20/2017)... ... July 20, 2017 , ... Acute myeloid ... cancer that progresses rapidly without treatment. Newly diagnosed patients face intense chemotherapy regimens ... reoccurrence and relapse. With such a challenging diagnosis that requires immediate action, ...
(Date:7/20/2017)... ... ... For individuals with extended hospital stays or who are residents of nursing ... specially designed to accommodate patients with a wide range of ailments or special needs, ... has invented the patent-pending PORTABLE ARM REST, a specially designed armrest that features many ...
(Date:7/20/2017)... ... 2017 , ... Doctors on Liens, the leading network of medical providers working ... by Dr. Russell Horine, DC to their exclusive list of medical professionals. Horine Chiropractic ... serving as the clinic director and his son Dr. Lee Horine and daughter-in-law Dr. ...
(Date:7/20/2017)... ... July 20, 2017 , ... Using CDRH’s Medical Device Quality ... 1:30 p.m. – 3:00 p.m. ET, http://www.fdanews.com/mdqualitydata          , Device makers have ... known as the “CY2016 Annual FDA Medical Device Quality System Data” report. CDRH ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)...  Centurion Medical Products, a leader in medical product innovation and ... removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are part of a ... pain while preventing unneeded emergency department admission due to severe fecal ...
(Date:7/11/2017)... Zymo Research Corp., also known as ,The Epigenetics Company, announced today the ... precise manner using the myDNAge ™ test. Based on Horvath,s Clock, ... genetics and biostatistics at the David Geffen School of Medicine at ... proprietary DNAge ™ technology is used to analyze DNA methylation patterns ... ...
(Date:7/11/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ( ... development of oral drug delivery systems, announced today that ... to schedule an End-of-Phase II meeting with Oramed for ... insulin capsule ORMD-0801 in the treatment of type 2 ... endpoints by indicating a statistically significant lowering of glucose ...
Breaking Medicine Technology: