Navigation Links
How bacteria found in mouth may cause colorectal cancer
Date:8/14/2013

Gut microbes have recently been linked to colorectal cancer, but it has not been clear whether and how they might cause tumors to form in the first place. Two studies published by Cell Press on August 14th in the journal Cell Host & Microbe reveal how gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors. The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer.

"Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," says senior study author Wendy Garrett of the Harvard School of Public Health and the Dana-Farber Cancer Institute.

Colorectal cancer is the second leading cause of cancer-related death in the United States. Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients. But until now, it was not known whether these microbes directly contribute to the formation of tumors.

In one of the new studies, Garrett, Matthew Meyerson of the Dana-Farber Cancer Institute, and their collaborators found that fusobacteria are prevalent in human adenomas -- benign tumors that can become malignant over time -- suggesting that these microbes contribute to early stages of tumor formation. In a mouse model of colorectal cancer, these bacteria accelerated the formation of tumors by attracting immune cells called myeloid cells, which invade tumors and stimulate inflammatory responses that can cause cancer.

In the second study, Yiping Han of Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called Fusobacterium adhesin A (FadA), which is found on the surface of these bacterial cells, to a
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pharmacy Robots Linked to Bacterial Contamination of Drugs
2. Children with juvenile arthritis have higher rates of bacterial infection
3. University of Minnesota startup to treat challenging bacterial infection
4. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
5. Zooming in on bacterial weapons in 3-D
6. Genomes show how Staph bacteria gain resistance to last-line drug
7. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
8. Killer stainless steel: New process gives icon of cleanliness antibacterial coating
9. Study Ties Kids Allergy Risks to Antibacterials, Preservatives
10. Rare Drug-Resistant Bacteria Spotted in U.S. Hospital
11. Eating garbage: Bacteria for bioremediation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... ANS and Dr. Yaron Moshel offer answers to some common ... what the future holds for Brain Tumor Surgery. , What ... base surgery is a form of highly specialized brain surgery ... considered very delicate and relatively inaccessible. In the past, the ... brain tissue, leading to more neurological damage. Modern philosophy is ...
(Date:7/31/2014)... 2014 The rising population of baby ... the global geriatric care services market wherein a new ... these services across the globe. There are service providers ... agency to few large companies with national and even ... and is also highly fragmented. The developed nations have ...
(Date:7/31/2014)... bipartisan support would allow Medicare to test a concept ... the health of patients with chronic illness while reducing ... need most. , The bill, introduced last week by ... of a decade of work by health policy researchers ... Innovation. It would allow Medicare Advantage plans to use ...
(Date:7/31/2014)... The Never Give Up 26 Foundation looks forward to ... Simply bring your ticket and Mention Never Give Up ... friends and family. , Packy had unique internal ... contagious optimism continues to impact the lives of many. ... pursue a happy life was truly a testament to his ...
(Date:7/31/2014)... According to a new market research report, the "Inertial ... Europe, Asia-Pacific, the Middle East, and ROW) - Forecast ... is estimated at $2.75 billion in 2014 and is ... navigation system market for defense segment is estimated at ... $3.33 billion by 2019. The inertial navigation system market ...
Breaking Medicine News(10 mins):Health News:Dr. Yaron Moshel of Atlantic NeuroSurgical Specialists (ANS) Discusses Brain Tumor Surgery 2Health News:Dr. Yaron Moshel of Atlantic NeuroSurgical Specialists (ANS) Discusses Brain Tumor Surgery 3Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 2Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 3Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 4Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 5Health News:Don't Forget To Mention Never Give Up 26 Foundation 2Health News:Inertial Navigation System Market Worth $4.63 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Inertial Navigation System Market Worth $4.63 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Inertial Navigation System Market Worth $4.63 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Inertial Navigation System Market Worth $4.63 Billion by 2019 - New Report by MarketsandMarkets 5
... Heads New Department, NEW YORK, Sept. 11 ... Nick Childs, 38, an award-winning filmmaker,is joining the agency,s ... a new position. This marks the first in a,series ... the,transformation of Grey New York to the next level, ...
... Sparta Systems, Inc., (Sparta),the maker of TrackWise(R), ... and,compliance management software, today announced that NAMSA, ... evaluation of medical devices,deployed TrackWise to lower ... implementation, including validation, was completed,within six months. ...
... E protects their hearts , , TUESDAY, Sept. 11 (HealthDay ... heart-lung machine can shrink the gender gap in survival ... study finds. , The bypass results are "good news ... author of the study that reviewed more than 11,000 ...
... Natural Nutrition, Inc.,(OTC Bulletin Board: NNTN) announced ... athlete, has signed an agreement to act ... direct marketing campaign.,Natural Nutrition will be releasing ... be directly marketed via the internet, infomercials, ...
... The Substance Abuse and,Mental Health Services Administration ... inaugural Science and Service Awards. These awards,recognize ... treat mental illnesses and substance abuse., ... to public sector,organizations and community-based groups and ...
... Alive Founder Bonnie Bernard Attending Prestigious Political,Forum in Ft. ... businesswoman,who founded a human embryo adoption agency has been ... scheduled for Sept. 17 in,Ft. Lauderdale, FL. Bonnie Bernard ... expert on the topic of frozen embryos and their,viability ...
Cached Medicine News:Health News:Nick Childs Joins Grey New York as Director of Content Development 2Health News:NAMSA Deploys TrackWise Software as its Quality Management System 2Health News:Bypass 'Off-Pump' Boosts Women's Outcomes 2Health News:Bypass 'Off-Pump' Boosts Women's Outcomes 3Health News:Fitness Champion Natalie Waples to be Spokesperson for Natural Nutrition International Direct Marketing Campaign 2Health News:SAMHSA Announces First Science and Service Award Winners 2Health News:SAMHSA Announces First Science and Service Award Winners 3Health News:SAMHSA Announces First Science and Service Award Winners 4Health News:Cincinnati Adoption Agency Invited to Participate in Values Voter Presidential Debate 2
(Date:7/31/2014)... , July 31, 2014 Touro University California,s ... been selected as the recipient of a $150,000 grant ... allow the University to increase research and classroom space ... state-of-the-art technology for the study of health sciences, and ... diverse needs and interests of our students," said ...
(Date:7/31/2014)... July 31, 2014 Catylix, Inc. ( ... ( Milpitas, California ) announced today ... and commercialize new fluorination products and related chemistry. ... benefited from the use of substituents that are ... with polarity to improve binding and bioavailability. Fluorinated ...
(Date:7/31/2014)... and LONDON , July 31, 2014 /PRNewswire/ ... services provider for the medical industries, announced today the incorporation of ... United Kingdom has one of the largest ... 8.9 billion in 2012 and it is projected to increase by ... USD 234 billion in 2012, equal to 9.5% of GDP. Despite ...
Breaking Medicine Technology:Touro University California Garners Grant From Long Foundation 2Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2genae Opens Offices in London 2
... 25, 2011 Newport Audiology Centers announced ... Colorado, to Nashville, Tennessee. The new Nashville Operations Center ... its key partners and expand operations across their consumer, ... are very excited by the opportunities Nashville will bring," ...
... China, July 25, 2011 /PRNewswire-Asia/ -- The whole healthcare ... technology trends and social economic increases. Generally speaking, several ... rapid increase of world population especially the aging ... are increasing in both developed and developing countries. They ...
Cached Medicine Technology:Avoid Illness Through Easy Daily Check 2
... Deviation Splint uses safe, mild to moderate ... deviation at the MP joints. Dorsal-based splint ... and ulnar polycentric hinges located at the ... Padded, malleable finger rings can be individually ...
... FREEDOM® Boxer Fracture Prefab Orthosis For ... fractures. Rigid Kydex shell immobilizes and ... T-Foam™ padded interior adds comfort, support, ... In hard-to-fit cases, the shell may ...
Combination Oppenheimer with Knuckle Bender - to dorsiflex wrist and flex MCP joints; includes two attachments to extend/flex distal finger joints....
... makes dynamic splinting easier and faster. ... fit every splinting need. Non-slip foam ... the distal phalanx. One size is ... 10 and 25. FoamWrap™ splints are ...
Medicine Products: