Navigation Links
How bacteria found in mouth may cause colorectal cancer
Date:8/14/2013

Gut microbes have recently been linked to colorectal cancer, but it has not been clear whether and how they might cause tumors to form in the first place. Two studies published by Cell Press on August 14th in the journal Cell Host & Microbe reveal how gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors. The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer.

"Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," says senior study author Wendy Garrett of the Harvard School of Public Health and the Dana-Farber Cancer Institute.

Colorectal cancer is the second leading cause of cancer-related death in the United States. Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients. But until now, it was not known whether these microbes directly contribute to the formation of tumors.

In one of the new studies, Garrett, Matthew Meyerson of the Dana-Farber Cancer Institute, and their collaborators found that fusobacteria are prevalent in human adenomas -- benign tumors that can become malignant over time -- suggesting that these microbes contribute to early stages of tumor formation. In a mouse model of colorectal cancer, these bacteria accelerated the formation of tumors by attracting immune cells called myeloid cells, which invade tumors and stimulate inflammatory responses that can cause cancer.

In the second study, Yiping Han of Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called Fusobacterium adhesin A (FadA), which is found on the surface of these bacterial cells, to a
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pharmacy Robots Linked to Bacterial Contamination of Drugs
2. Children with juvenile arthritis have higher rates of bacterial infection
3. University of Minnesota startup to treat challenging bacterial infection
4. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
5. Zooming in on bacterial weapons in 3-D
6. Genomes show how Staph bacteria gain resistance to last-line drug
7. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
8. Killer stainless steel: New process gives icon of cleanliness antibacterial coating
9. Study Ties Kids Allergy Risks to Antibacterials, Preservatives
10. Rare Drug-Resistant Bacteria Spotted in U.S. Hospital
11. Eating garbage: Bacteria for bioremediation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... ... July 02, 2015 , ... Patton State Hospital (PSH) ... Hospitals. Prior to using Winscribe’s dictation and clinical documentation solutions, Patton State Hospital ... their organization’s dictation and transcription processes. , Over the years, PSH’s ...
(Date:7/1/2015)... ... July 01, 2015 , ... In the United States, summer has ... Middle-Eastern countries like Saudi Arabia and Dubai, the summer temperatures are so hot, that ... Celebrity dentist Dr. Sam Saleh of ORA Dentistry Spa notes that a trip to ...
(Date:7/1/2015)... ... , ... For decades, researchers in the genetics field have theorized that the ... changing after development in the womb. Now, researchers from the Icahn School of Medicine ... life – a process which helps to switch genes on and off. This histone ...
(Date:7/1/2015)... , ... July 01, 2015 , ... ... forms, such as organically raised chickens and eggs. Eating organic foods and products ... is cleaner and more environmentally friendly than production chicken farming. Choosing home raised ...
(Date:7/1/2015)... ... July 01, 2015 , ... OncLive® ... Corporation of America (HCA), as it further expands its Strategic Alliance Partnership Program ... With this new partnership, OncLive’s editorial and marketing teams will collaborate with Sarah ...
Breaking Medicine News(10 mins):Health News:Patton State Hospital Saves Over 50% and Removes Document Backlogs with Winscribe Text 2Health News:Patton State Hospital Saves Over 50% and Removes Document Backlogs with Winscribe Text 3Health News:Patton State Hospital Saves Over 50% and Removes Document Backlogs with Winscribe Text 4Health News:Dr. Sam Saleh Invites Vacationing International Patients to Get a Same-Day Hollywood Smile During the July Travel Season 2Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 2Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 3Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 4Health News:Chicken Coop Condo Offer New Chicken Coop Designs 2Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 2Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 3
... bring Wellness Program to hundreds of locations. , ... ... provider of online wellness solutions, announced it has signed an agreement ... nutrition services to hospitals and senior living communities across the country. ...
... CHOP, BALA CYNWYD, Pa., Sept. 28 Philadelphia,Insurance ... the 2008,Parkway Run/Walk benefiting The Cancer Center at The ... Despite the,rain, more than 1,500 runners & walkers (including ... event. Following the 5k run, PHLY,employees presented the check ...
... required for the earliest steps in embryonic development also plays ... of adult animals, scientists have revealed. An apparent "hub" ... be a potential target for drugs to enhance or interfere ... online this week and appear in the October issue of ...
... Muasher Center for Fertility and IVF is ... In Vitro Fertilization treatment to qualifying patients. ... Fertility Doctor], Dr. Suheil Muasher, M.D., FACOG, ... coverage who meet certain clinical criteria to ...
... Hundreds to "finish" fallen marathon runner,s race and raise funds for ... ... BOSTON, Sept. 27 On Sunday, September 28,for the seventh year ... "finish the race" for Dr. Cynthia Lucero, the talented young,psychologist who died ...
... Paul D.,Wellstone Muscular Dystrophy Community Assistance, Research and ... today.,It now goes to President Bush, who is ... -- which reauthorizes and updates the MD-CARE,Act of ... of treatments for,several forms of muscular dystrophy., ...
Cached Medicine News:Health News:Nation's Leading Food Services Provider Chooses PureWellness to Drive Corporate Wellness Program 2Health News:Philadelphia Insurance Companies Believes in 'Giving Back through Fitness' 2Health News:'Hub' of fear memory formation identified in brain cells 2Health News:'Hub' of fear memory formation identified in brain cells 3Health News:Lower Cost Minimal Stimulation IVF Being Performed by Virginia Fertility Doctor, Suheil Muasher 2Health News:Lower Cost Minimal Stimulation IVF Being Performed by Virginia Fertility Doctor, Suheil Muasher 3Health News:MSPP Holds Seventh Annual 5K Lucero Memorial Run and Latino Mental Health Breakfast on Sunday, September 28, 2008 2Health News:MSPP Holds Seventh Annual 5K Lucero Memorial Run and Latino Mental Health Breakfast on Sunday, September 28, 2008 3Health News:Updated MD-CARE Act Receives Final Congressional Approval 2
(Date:7/1/2015)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ), ... and neurologic disorders, announced today the results of a ... Company,s lead compound. Results from the study show that ... inhibit the activation of inflammatory proteins in the blood ... in a Phase 1 clinical trial under a Medicines ...
(Date:7/1/2015)... July 1, 2015 Radiant Insights ... Stationary Oxygen Concentrators Market Shares, Strategy, and Forecasts, ... achieve continuing growth as the aging population worldwide needs ... respiratory conditions where oxygen is able to improve the ... devices have become affordable and support a mobile lifestyle ...
(Date:7/1/2015)... , July 1, 2015 OncoSec Medical Inc. ("OncoSec") ... immunotherapies, today announced that CEO and President Punit Dhillon ... the Company,s listing to The Nasdaq Stock Market at 9:30 ... in New York City .   ... and stakeholders, we are honored to open the Nasdaq to ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Reports Human Proof of Principle Study of Lead Compound Demonstrating Inhibition of Inflammatory Markers In White Blood Cells 2Rock Creek Pharmaceuticals Reports Human Proof of Principle Study of Lead Compound Demonstrating Inhibition of Inflammatory Markers In White Blood Cells 3Rock Creek Pharmaceuticals Reports Human Proof of Principle Study of Lead Compound Demonstrating Inhibition of Inflammatory Markers In White Blood Cells 4Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 2Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 3Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 4OncoSec Medical to Ring The Nasdaq Stock Market Opening Bell 2OncoSec Medical to Ring The Nasdaq Stock Market Opening Bell 3
... 17 Senesco Technologies, Inc. ("Senesco" or the "Company") ... three months ended September 30, 2009. , Net loss for ... $0.01 per share, compared with a net loss of $1,181,406, or ... 2008. This decrease in net loss was primarily the result ...
... DURHAM, N.C., Nov. 17 Oxygen Biotherapeutics, Inc. (OTC ... begun shipping Dermacyte(TM) Oxygen Concentrate Gel to customers who ... are going out today, cover orders received through early ... our company - actually shipping a product to customers ...
Cached Medicine Technology:Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 2Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 3Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 4Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 5Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 6Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 7Oxygen Biotherapeutics, Inc. Begins Shipping Cosmetic Product to Customers 2
... is made of Kydex and ... and back sections are adjustable ... to facilitate air circulation and ... and washable. Model C-18 is ...
... Orthosis ensures comfort and immobilization ... anterior frame and occipital component. ... flow and easy application. Large ... For added comfort, removable, flannel-covered, ...
Exo-Deluxe Overhead Traction for hospital or home care. Twice the clearance of other units between the patient and supporting wall. 2" nylon pulleys with polypropylene cord, head halter, spreader bar...
... perfect for use for lightweight padding. It ... used to line braces, prosthetics, orthotics and ... and vibration and conforms to all body ... It is a 2mm thick gel sheet ...
Medicine Products: