Navigation Links
How bacteria found in mouth may cause colorectal cancer
Date:8/14/2013

Gut microbes have recently been linked to colorectal cancer, but it has not been clear whether and how they might cause tumors to form in the first place. Two studies published by Cell Press on August 14th in the journal Cell Host & Microbe reveal how gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors. The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer.

"Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," says senior study author Wendy Garrett of the Harvard School of Public Health and the Dana-Farber Cancer Institute.

Colorectal cancer is the second leading cause of cancer-related death in the United States. Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients. But until now, it was not known whether these microbes directly contribute to the formation of tumors.

In one of the new studies, Garrett, Matthew Meyerson of the Dana-Farber Cancer Institute, and their collaborators found that fusobacteria are prevalent in human adenomas -- benign tumors that can become malignant over time -- suggesting that these microbes contribute to early stages of tumor formation. In a mouse model of colorectal cancer, these bacteria accelerated the formation of tumors by attracting immune cells called myeloid cells, which invade tumors and stimulate inflammatory responses that can cause cancer.

In the second study, Yiping Han of Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called Fusobacterium adhesin A (FadA), which is found on the surface of these bacterial cells, to attach to and invade human colorectal cancer cells. FadA then turns on cancer growth genes and stimulates inflammatory responses in these cells and promotes tumor formation.

Han and her team also found that FadA levels were much higher in tissues from patients with adenomas and colorectal cancer compared with healthy individuals. Moreover, they identified a compound that can prevent FadA's effects on cancer cells. "We showed that FadA is a marker that can be used for the early diagnosis of colorectal cancer and identified potential therapeutic targets to treat or prevent this common and debilitating disease," Han says.


'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. Pharmacy Robots Linked to Bacterial Contamination of Drugs
2. Children with juvenile arthritis have higher rates of bacterial infection
3. University of Minnesota startup to treat challenging bacterial infection
4. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
5. Zooming in on bacterial weapons in 3-D
6. Genomes show how Staph bacteria gain resistance to last-line drug
7. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
8. Killer stainless steel: New process gives icon of cleanliness antibacterial coating
9. Study Ties Kids Allergy Risks to Antibacterials, Preservatives
10. Rare Drug-Resistant Bacteria Spotted in U.S. Hospital
11. Eating garbage: Bacteria for bioremediation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... and safety labels , has been featured in the National Electrical ... The eiXtra e-newsletter provides electroindustry professionals with manufacturer, regulatory, and standardization news. The ...
(Date:5/24/2016)... ... 24, 2016 , ... After graduating from Cornell, author Joshua Alexander ... on medication, living on Social Security disability and staying in a group home. In ... It!” (published by Balboa Press), Alexander shares how he was finally able to heal ...
(Date:5/24/2016)... ... May 24, 2016 , ... Design Concepts , a ... del Quinto Sol Wheel Park’ in Pueblo, Colorado. This park was designed working ... special for this often overlooked neighborhood. Located at 609 E. 6th Street, Pueblo’s ...
(Date:5/24/2016)... ... 24, 2016 , ... NutraPre today announced the nationwide release ... to prevent morning sickness and promote overall heath. Engineered with advanced nanotechnology, this ... of water. , “Imagine a pregnancy without morning sickness,” NutraPre CEO Eddie Cameron ...
(Date:5/23/2016)... ... ... to an article published May 12th on the Medical Daily, as a great ... article points out that, as long as patients are brushing as they should – twice ... course, these worn-out bristles won’t clean teeth and gum tissue as effectively, so the article ...
Breaking Medicine News(10 mins):
(Date:5/19/2016)... Oregon , May 19, 2016 ... titled, World Medical/Diagnostic Imaging Market -Opportunities and Forecasts, 2015 ... reach $45.0 billion by 2022, registering a CAGR of ... expected to continue to be the highest revenue-generating segment ... accounted for around one-third of the market share ...
(Date:5/19/2016)... -- The equities market is never short of ... is without doubt the Healthcare space. ActiveWallSt.com has uncovered four ... Alkermes PLC (NASDAQ: ALKS ), AMAG Pharmaceuticals Inc. ... IDXX ), and Atossa Genetics Inc. (NASDAQ: ... http://www.activewallst.com/ On Wednesday, Alkermes PLC,s ...
(Date:5/19/2016)... 2016 MGB Biopharma, a ... Anti-infectives, Welcomes the Final Instalment of Lord Jim ...   Lord Jim O,Neill,s ... recommendations, providing a comprehensive action plan for the ... rising threat of superbugs - something that could ...
Breaking Medicine Technology: