Navigation Links
How arthritis thrives
Date:1/25/2010

The links between autoimmune diseases, infections, genetics and the environment are complex and mysterious. Why are people who live near airports more susceptible to autoimmune diseases like rheumatoid arthritis and lupus? How do hormones in meat trigger the onset of a disease?

Our immediate environment interacts with our genetic programming and can determine if we will succumb to an autoimmune disease, says rheumatologist Prof. Michael Ehrenfeld of Tel Aviv University's Sackler School of Medicine, who is seeking to unravel those mysteries. Prof. Ehrenfeld recently published a report in Autoimmune Reviews on how "Spondylo-arthropathies," a group of common inflammatory rheumatic disorders, appear to be triggered by environmental factors. He has also done research on how the dry-eye and mouth disease "Sjgren's syndrome" can be triggered by environmental influences.

Minimizing the risks

"The onset of autoimmune diseases is a mixture of genetics, which you can't change, and environmental factors, which in some cases you can," says Prof. Ehrenfeld. While he cites pollution as a trigger in many autoimmune disorders, "there are some environmental factors harder to avoid. For example, reactive arthritis is caused by a severe gastro-intestinal, urinary or sexual infection in some people," he says.

Afflicting more than 2 million Americans, rheumatoid arthritis, is a chronic inflammatory autoimmune disease, three times more prevalent in women than men. The disorder causes the body's own immune system to attack its joints, leading to pain, deformities and a substantial loss of mobility.

It is still impossible to tell which genes encode this disease and make some people more susceptible to autoimmune diseases, but there are some basic behaviors that may keep these disorders at bay. One root cause of arthritis is extreme stress, says Prof. Ehrenfeld, for which there are already therapeutic strategies. And some medications, such as the birth control pills, might be linked in some cases to the onset of lupus.

"You won't know if taking the pill or getting a certain virus will trigger arthritis, because we don't yet know the genes that encode the various autoimmune diseases," he says. "Obviously those people whose family members share a history of rheumatoid arthritis, or other autoimmune diseases including thyroid problems, should be more vigilant, because their chances are higher."

Triggers include hairspray and lipstick

Environmental pollution is also a cause for concern to those genetically predisposed to an autoimmune disease. Second-hand smoke, food chemicals or chemicals in the air, jet fuel fumes, UV exposure and other forms of environmental pollution are amongst the triggers considered to provoke the onset of autoimmune diseases.

Industrial regions, particularly in Northern Europe and North America, still exhibit the highest rates of most autoimmune diseases. But on a much more local scale, Prof. Ehrenfeld also singles out hairspray as well as lipstick as known occasional triggers.

"Most people think arthritis has to do with old age," says Prof. Ehrenfeld. "This is false. There is only one major type of arthritis in older people: osteoarthritis, which is brought on by degenerative changes in the body. What you see in older adults is usually a non-inflammatory and non-autoimmune type of arthritis.

"Most of the other kinds of arthritis we see in the clinic, the debilitating and inflammatory types, usually occur in young women between the ages of 20 and 40," Prof. Ehrenfeld says. "We hope that our research will lessen the occurrence and onset of these painful disorders."


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related medicine news :

1. Rheumatoid Arthritis Drug Lowers Flu Shot Effectiveness
2. Arthritis Foundation Bestows Highest National Awards
3. Lots of Exercise in Midlife May Lead to Osteoarthritis
4. Osteoarthritis Costs U.S. Over $185 Billion a Year
5. Too much physical activity may lead to arthritis
6. XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation
7. Research shows Tai Chi exercise reduces knee osteoarthritis pain in the elderly
8. New Clues to How Fish Oils Help Arthritis Patients
9. UAB creates national network to advance personalized medicine in rheumatoid arthritis
10. Glucosamine Fails Osteoarthritis Test
11. CEL-SCI Presents Data at American College of Rheumatology Conference Which Suggests that CEL-2000 Has Potential to Slow Damage Caused by Rheumatoid Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How arthritis thrives
(Date:9/22/2017)... ... September 22, 2017 , ... First Choice ... celebrating the one year anniversary of its Houston-Fallbrook facility. , “We are ... Facility Medical Director of First Choice Emergency Room Houston-Fallbrook. “It has been a ...
(Date:9/22/2017)... ... ... “Letters From Home”: a moving compilation of letters that remind readers of the ... is the creation of published author, John Allred, a passionate leader of ministry to ... who has traveled and ministered on four continents. , “It is my hope and ...
(Date:9/21/2017)... , ... September 21, 2017 , ... With ProSlideshow Portrait ... and easy to do. Users can select from up to two layers of subject ... click of a mouse all within Final Cut Pro X. , With ...
(Date:9/21/2017)... , ... September 21, 2017 , ... ... learn with Infinity Behavioral Health Services for professionals in the addiction treatment industry ... Payer Audit . , Insurance companies and state and federal governments are ...
(Date:9/21/2017)... ... September 21, 2017 , ... Bill Howe Plumbing’s mission is to create an ... to the community. For over 37 years, they have operated with their mission at ... in San Diego. They were chosen as the Best San Diego plumber in ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... -- Eli Lilly and Company (NYSE: LLY ... galcanezumab and lasmiditan, two investigational treatments for migraine, at ... taking place Sept. 7-10 in Vancouver ... data from an open-label study evaluating the safety and ... 240 mg) for the prevention of migraine. Galcanezumab is ...
(Date:9/5/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) (TASE: ... on the development of oral drug delivery systems, announced ... the U.S. Food and Drug Administration (FDA) regarding ORMD-0801, ... At the meeting, the FDA gave ... ORMD-0801, would be a Biologics License Application (BLA).  Such ...
(Date:8/29/2017)... , Aug. 29, 2017 ivWatch, LLC, the leading provider ... infiltrations, announced it has been awarded an Innovative Technology contract from ... the country. ... device to aid in the early detection of peripheral IV infiltration ... The Innovative Technology contract ...
Breaking Medicine Technology: