Navigation Links
How amyloid beta reduces plasticity related to synaptic signaling
Date:12/28/2009

The early stages of Alzheimer's disease are thought to occur at the synapse, since synapse loss is associated with memory dysfunction. Evidence suggests that amyloid beta (Aβ) plays an important role in early synaptic failure, but little has been understood about Aβ's effect on the plasticity of dendritic spines.

These spines are short outgrowths of dendrites (extensions of neurons) that relay electrical impulses in the brain. A single neuron's dendrite contains hundreds of thousands of spines, providing memory storage and transmission of signals across the synapse the junction where such nerve impulses occur. Plasticity of these spines, or the ability to change and grow, is essential for the transmission of signaling in the brain.

Researchers led by Roberto Malinow, MD, PhD, professor of neurosciences and Shiley-Marcos Endowed Professor in Alzheimer's Disease Research at the University of California, San Diego School of Medicine, have shed more light on how Aβ's destructive effects on the brain are related to its impact on the plasticity of dentritic spines. Their study was published on December 27 in the journal Nature Neuroscience.

The researchers have shown that if Aβ is over-produced by either the pre-or post-synaptic side of the axon, it can cause destructive effects. Secondly, these effects are over a distances of about 10 microns of the neuron affecting thousands and thousands of synapses.

"We found that amyloid beta affects structural and not just functional, plasticity," said Malinow. "Normally, plasticity can be induced, which makes synapses stronger and bigger, but amyloid beta prevents this."

According to Malinow, it also appears that continuous release of Aβ is required to prevent plasticity. "Even a short window of 30 to 60 minutes without Aβ secretion is enough to permit plasticity to occur," he said. As Aβ's effect on the dendritic spines critical for memory had been thought to be irreversible, this shows that there is a hope of change if scientists learn how to stop the secretion of Aβ at synaptic sites."

"Our results show that the continuous production of Aβ at dendrites or axons acts locally to reduce the number and plasticity of synapses," Malinow concluded.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Manipulating brain inflammation may help clear brain of amyloid plaques, Mayo Clinic researchers say
2. HerbalScience Research Demonstrates that Optimized Turmeric Extract Inhibits Amyloid-Beta Accumulation, a Hallmark of Alzheimers Disease
3. A Phase III Alzheimers Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits
4. Novel role of protein in generating amyloid-beta peptide
5. Amyloid Beta Level in Serum Predicts Risk for Vascular Disease in First-Degree Relatives of Alzheimer's Patients
6. Neurochem moves eprodisate (KIACTA(TM)) drug development program forward for Amyloid A amyloidosis
7. Neurochem announces European opinion for Eprodisate (KIACTA(TM)) for the treatment of AA amyloidosis
8. News brief: Knockdown of E2F1 reduces invasive potential of melanoma cells
9. Researchers find increased dairy intake reduces risk of uterine fibroids in black women
10. Outpatient Palliative Care Reduces Hospitalizations, Which Impact Costs, While Improving Quality of Life for Seniors and Family Caregivers - New Study in American Journal of Managed Care
11. Elastography reduces unnecessary breast biopsies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the ... medical article to the newly revamped Cosmetic Town journal section, featuring ... transplant procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and Company ... results for the third quarter of 2017 on Tuesday, ... call on that day with the investment community and ... The conference call will begin at 9 a.m. ... access a live webcast of the conference call through ...
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology: