Navigation Links
How amyloid beta reduces plasticity related to synaptic signaling
Date:12/28/2009

The early stages of Alzheimer's disease are thought to occur at the synapse, since synapse loss is associated with memory dysfunction. Evidence suggests that amyloid beta (Aβ) plays an important role in early synaptic failure, but little has been understood about Aβ's effect on the plasticity of dendritic spines.

These spines are short outgrowths of dendrites (extensions of neurons) that relay electrical impulses in the brain. A single neuron's dendrite contains hundreds of thousands of spines, providing memory storage and transmission of signals across the synapse the junction where such nerve impulses occur. Plasticity of these spines, or the ability to change and grow, is essential for the transmission of signaling in the brain.

Researchers led by Roberto Malinow, MD, PhD, professor of neurosciences and Shiley-Marcos Endowed Professor in Alzheimer's Disease Research at the University of California, San Diego School of Medicine, have shed more light on how Aβ's destructive effects on the brain are related to its impact on the plasticity of dentritic spines. Their study was published on December 27 in the journal Nature Neuroscience.

The researchers have shown that if Aβ is over-produced by either the pre-or post-synaptic side of the axon, it can cause destructive effects. Secondly, these effects are over a distances of about 10 microns of the neuron affecting thousands and thousands of synapses.

"We found that amyloid beta affects structural and not just functional, plasticity," said Malinow. "Normally, plasticity can be induced, which makes synapses stronger and bigger, but amyloid beta prevents this."

According to Malinow, it also appears that continuous release of Aβ is required to prevent plasticity. "Even a short window of 30 to 60 minutes without Aβ secretion is enough to permit plasticity to occur," he said. As Aβ's effect on the dendritic spines critical for memory had been thought to be irreversible, this shows that there is a hope of change if scientists learn how to stop the secretion of Aβ at synaptic sites."

"Our results show that the continuous production of Aβ at dendrites or axons acts locally to reduce the number and plasticity of synapses," Malinow concluded.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Manipulating brain inflammation may help clear brain of amyloid plaques, Mayo Clinic researchers say
2. HerbalScience Research Demonstrates that Optimized Turmeric Extract Inhibits Amyloid-Beta Accumulation, a Hallmark of Alzheimers Disease
3. A Phase III Alzheimers Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits
4. Novel role of protein in generating amyloid-beta peptide
5. Amyloid Beta Level in Serum Predicts Risk for Vascular Disease in First-Degree Relatives of Alzheimer's Patients
6. Neurochem moves eprodisate (KIACTA(TM)) drug development program forward for Amyloid A amyloidosis
7. Neurochem announces European opinion for Eprodisate (KIACTA(TM)) for the treatment of AA amyloidosis
8. News brief: Knockdown of E2F1 reduces invasive potential of melanoma cells
9. Researchers find increased dairy intake reduces risk of uterine fibroids in black women
10. Outpatient Palliative Care Reduces Hospitalizations, Which Impact Costs, While Improving Quality of Life for Seniors and Family Caregivers - New Study in American Journal of Managed Care
11. Elastography reduces unnecessary breast biopsies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... 2017 , ... Tribble Insurance Agency, a family owned and operated firm offering ... charity event to honor Chad Phillip Dermyer, a local police trooper who was shot ... and his fellow officers were conducting routine stops of suspects when one of them, ...
(Date:1/19/2017)... ... January 19, 2017 , ... For the second consecutive year, ... Connecticut (RMACT) have earned “Top Doctor” awards. Dr. Mark Leondires, Dr. Spencer Richlin, ... been chosen by their peers for the 2017 list based on their exceptional ...
(Date:1/19/2017)... ... January 19, 2017 , ... Sales Focus Inc. (SFI), a Maryland-based sales ... market. , Over the past 20 years SFI has been recognized as the world’s ... six new clients into the US market. The new clients include: Panacea Pro, ...
(Date:1/19/2017)... ... January 19, 2017 , ... Fillers are known ... Few people know that popular cosmetic fillers can enhance earlobes and ... medical director of the MilfordMD Cosmetic Dermatology Surgery & Laser Center, in Milford, ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... of Bioengineering are collaborating on a research project focused on multiple sclerosis (MS). ... seeks to use nanotechnology to control the disease without compromising normal immune function ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , January 19, 2017 ... administration appears serious about reducing the FDA,s regulatory ... innovation in the medical drug industry, many of ... with new clinical trials and development of advanced ... forging ahead with recent developments include:  Moleculin Biotech, ...
(Date:1/19/2017)... 2017  Magnetic Insight Inc., leader in magnetic ... agreement with inviCRO LLC to develop intuitive image ... based on inviCRO,s VivoQuant™ visualization and post processing ... complete MPI solution package with the Momentum MPI ... imaging in vivo. MPI is a ...
(Date:1/18/2017)... 18, 2017  EnteroMedics Inc. (NASDAQ: ... neuroblocking technology to treat obesity, metabolic diseases and ... an underwritten public offering of units for gross ... discounts and commissions and offering expenses payable by ... Class A Units, priced at a public offering ...
Breaking Medicine Technology: