How adhesive protein causes malaria ( Researchers at the Swedish medical u...)

How adhesive protein causes malaria

Date:9/25/2007

Researchers at the Swedish medical university Karolinska Institutet (KI) and the Swedish Institute for Infectious Disease Control (SMI) have identified the biochemical mechanism behind the adhesive protein that give rise to particularly serious malaria in children. The knowledge of how the malaria parasite makes blood vessels become sticky paves the way for a future vaccine for the disease, which currently kills some 2 million people every year.

Severe anaemia, respiratory problems and cardiac dysfunction are common and life-threatening symptoms of serious malaria infection. The diseases are caused when the malaria bacteria Plasmodium falciparium infects the red blood cells, which then accumulate in large amounts, blocking the flow of blood in the capillaries of the brain and other organs.

The reason that the blood cells conglomerate and lodge in the blood vessels is that once in the blood cell the parasite produces proteins that project from the surface of the cell and bind with receptor molecules on other blood cells and on the vessel wall, and thus act like a glue. The challenge facing scientists has been to understand why certain proteins produce a stronger adhesive and thus cause more severe malaria.

The research group, which is headed by Professor Mats Wahlgren at the Department of Microbiology, Tumour and Cell Biology, KI, has studied the adhesive protein PfEMP1 in children with severe malaria. The group has identified specific parts of PfEMP1 that are likely to bond more strongly to the receptors in the blood vessels, therefore producing a stronger adhesive effect. What the scientists show in their newly published study is that these protein parts are much more common in parasites that cause particularly severe malaria. If they can identify enough adhesive proteins causing severe malaria, it will be possible to design a vaccine that prepares the bodys own immune defence.

There are no vaccines yet that can prevent
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Special proteins to fight TB identified
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
5. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
6. Protein in urine foresees heart disease
7. Obese children may have abnormalities of lipoproteins
8. Dissecting Diabetes - Is protein AKT2 the cause of type 2 diabetes?
9. Protein causing spread of colon cancer identified
10. Protein Complex prevents cancer
11. Protein Fragments Blocking Cures Alzheimers Disease

Post Your Comments:

(Date:5/23/2013)... 2013 Get ready to sweat. , ... workout in conjunction with the Nutrié California Kick ... training participants will get the chance to work out ... Loser, The Dr. Oz Show, and The Dr. Phil ... and the undefeated UFC heavy-weight contender Daniel Cormier at ...

(Date:5/23/2013)... Woburn, MA (PRWEB) May 23, 2013 ... American made high-grade auto detailing systems , ... truck cleaning systems , as well as other ... across hundreds of nations worldwide, is now offering ... washer designed to help manage a myriad of ...

(Date:5/22/2013)... Pleasant Prairie, WI (PRWEB) May 23, 2013 ... company , introduced a new feature to its ... example from the agency’s client portfolio through an immersive, ... gives clients and prospective customers the ability to virtually ... Medical, a developer of medical technologies and services. Users ...

(Date:5/22/2013)... The Yoga of Lady Niguma was created by a ... This is the oldest yoga found in written form (in ... the partner of renowned Indian master and yogi Naropa, and the ... a female yoga master. , Lady Niguma taught the practice ... through a long lineage to the second Dalai Lama, Gendun Gyatso. ...

(Date:5/22/2013)... (PRWEB) May 22, 2013 TWITTER: @the_USO ... Family Tour together, heading to 8 countries in the next 6 ... Street, Cookie Monster and Members of Congress came together to show ... assembled 2,000 USO Care Packages for distribution to our ... celebrate the five-year partnership of Sesame Street and the USO as ...

Breaking Medicine News(10 mins):Health News:Kim Lyons, Gunter Schlierkamp, & Daniel Cormier To Host Fresno Charity Workout 2 Health News:Kim Lyons, Gunter Schlierkamp, & Daniel Cormier To Host Fresno Charity Workout 3 Health News:Commercial Pressure Washer Debuted By Daimer Industries For Wheelchair Cleaning 2 Health News:Commercial Pressure Washer Debuted By Daimer Industries For Wheelchair Cleaning 3 Health News:Commercial Pressure Washer Debuted By Daimer Industries For Wheelchair Cleaning 4 Health News:Catalyst Exhibits Debuts 360 Degree Virtual Tour of St. Jude Medical Trade Show Booth 2 Health News:Popular Yoga DVD, Lady Niguma Yoga Released for Sale Online 2 Health News:Popular Yoga DVD, Lady Niguma Yoga Released for Sale Online 3 Health News:The USO and Sesame Street Announce Spring Kick Off of World Tour at Biannual Care Package Service Project Event in DC 2 Health News:The USO and Sesame Street Announce Spring Kick Off of World Tour at Biannual Care Package Service Project Event in DC 3 Health News:The USO and Sesame Street Announce Spring Kick Off of World Tour at Biannual Care Package Service Project Event in DC 4 Health News:The USO and Sesame Street Announce Spring Kick Off of World Tour at Biannual Care Package Service Project Event in DC 5

[0] Kim Lyons, Gunter Schlierkamp, & Daniel Cormier To Host Fresno Charity Workout [0] Commercial Pressure Washer Debuted By Daimer Industries For Wheelchair Cleaning [0] Catalyst Exhibits Debuts 360 Degree Virtual Tour of St. Jude Medical Trade Show Booth [0] Popular Yoga DVD, Lady Niguma Yoga Released for Sale Online [0] The USO and Sesame Street Announce Spring Kick Off of World Tour at Biannual Care Package Service Project Event in DC

... , ... recently aired episode of “ The Real Housewives of Orange County ,” Dr. Milind ... he discussed rhinoplasty and Orange County breast augmentation with the 19 year-old. ... (Vocus) December ...

... ... regulatory compliance and increases operational efficiency by selecting Sensotech cutting edge wireless monitoring ... , ... (PRWEB) December 29, 2009 -- NMVAHCS improves safety and regulatory compliance and increases ...

... , ... HeartheBill.org Release Free App for House Health Care Act , ... Comprehending the over 2000 pages contained within HR 3200, the ... about to become almost 40% easier for Americans thanks to a cooperative effort between Hearthebill.org ...

... 28 The Providence Service Corporation (Nasdaq: PRSC ) ... last week by the United States Senate. The Senate ... Bill and therefore could still undergo substantial changes, has a ... many of the types of home and community based social ...

... researchers have identified a role for enhanced activation of ... of either the TSC1 or the TSC2 protein. As ... Philadelphia, in an accompanying commentary, these data provide a ... to those with TSC-associated tumors. Tuberous sclerosis complex ...

... need for another operation, research shows , MONDAY, Dec. 28 ... of a high-tech CT scan to check for post-brain surgery ... doctor,s bedside exam, but a new study suggests that the ... low-cost, simple, but elegant neurological exam appears to be superior ...

Cached Medicine News:Health News:Newport Beach Plastic Surgeon Educates About the Pros and Cons of Plastic Surgery 2 Health News:Newport Beach Plastic Surgeon Educates About the Pros and Cons of Plastic Surgery 3 Health News:New Mexico VA Health Care System Selects Sensotech Wireless Temperature Monitoring System 2 Health News:House Health Care Bill Becomes Up To 38% More Understandable 2 Health News:Providence Service Corporation Comments on Senate Health Care Reform 2 Health News:Providence Service Corporation Comments on Senate Health Care Reform 3 Health News:Bedside Exam Trumps Scan for Post-Brain Surgery Monitoring 2

Newport Beach Plastic Surgeon Educates About the Pros and Cons of Plastic Surgery New Mexico VA Health Care System Selects Sensotech Wireless Temperature Monitoring System House Health Care Bill Becomes Up To 38% More Understandable Providence Service Corporation Comments on Senate Health Care Reform 'Notch'ing up a role in the multisystem disease tuberous sclerosis complex Bedside Exam Trumps Scan for Post-Brain Surgery Monitoring

(Date:5/22/2013)... , May 22, 2013 ... the DEFLECT-I study demonstrates that Keystone Heart,s TriGuard ... TAVR (Transcatheter Aortic Valve Replacement) procedures when compared to ... announces consensus on the importance of preserving brain reserve ... for cerebral protection during cardiovascular procedures to minimize brain ...

(Date:5/22/2013)... 22, 2013 Milliman, Inc., a premier global consulting ... 2013 Milliman Medical Index (MMI), which measures the healthcare ... healthcare benefits through an employer-sponsored preferred provider organization (PPO) ... in 2013 is $22,030. "For the ... on a percentage basis was the lowest in the ...

(Date:5/22/2013)... YORK , May 22, 2013 ... LLP is investigating claims on behalf of investors of ... ISRG ) (CUSIP: 46120E602) who purchased Intuitive ... 18, 2013 (the "Class Period"). Such investors are advised ... at rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ...

Breaking Medicine Technology:New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 2 New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 3 New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 4 Annual Healthcare Cost for a Typical American Family is $22,030 According to 2013 Milliman Medical Index 2 SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Intuitive Surgical, Inc. - ISRG 2

[0] New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR [0] Annual Healthcare Cost for a Typical American Family is $22,030 According to 2013 Milliman Medical Index [0] SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Intuitive Surgical, Inc. - ISRG

... Reportlinker.com announces that a new market research report is available in its catalogue: ... Stakeholder Opinions: Vaccines in emerging markets (Latin ... , , ... Introduction , ...

... WEST WINDSOR, N.J. , July 7 ITelagen, ... announced that it was selected by Zweena, LLC of West ... record application. ITelagen, which was selected for its expertise in EHR ... this innovative solution. , , ...

Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina Zweena Selects ITelagen to Host Personal Health Records Application

The Pall High Performance HME is a high efficiency heat and moisture exchanger, indicated to protect patients against the potential risks of ventilation with dry and cold gases....

Passive heat and moisture exchangers for respiratory applications....

Ballard trach care HMES and filters, tv 1500, HME...

Medicine Products:

High Performance HME with Port Breathe-Easy™ for Tracheotomies HCH w/Flex Elbow TV 1500 HME