Navigation Links
How a cancer drug leads to diabetes
Date:4/3/2012

The drug known as rapamycin is widely used by cancer and transplant patients, and there are hints that it might even help us put off old age and live longer. But, it also comes with a downside: rapamycin leads to diabetes in as many as 15 percent of the people who take it.

Now, researchers reporting in the April Cell Metabolism, a Cell Press publication, have figured out why that is. The drug turns the insulin signal off in muscle, to prevent muscle cells from taking blood sugar in.

"This is a drug that is pretty well known for its benefits," said Pere Puigserver of Dana-Farber Cancer Institute. "Rapamycin is one of the few drugs, maybe the only one, that extends lifespan in organisms from yeast to mice to primates."

But the drug's diabetic side effects are troubling, and Puigserver's team now finds they arise in an interesting way. The key is a single transcription factor in muscle known as YY1. Mice lacking YY1 are protected from diabetes when they take rapamycin.

That's because rapamycin changes YY1 within muscle and that shift leads to chemical and structural modifications of the genes encoding insulin signals. Those changes effectively turn insulin off, keeping sugar from coming in.

That rapamycin leads to long life even as it causes insulin resistance remains something of a paradox, Puigserver says. His team does have hints that there may be other factors at play. For instance, he says diet might make the difference between those who develop diabetes while on rapamycin and those who do not.

The results also have fundamental interest as perhaps the first instance in which the nutrient signal mTOR -- the target of rapamycin -- has been tied to epigenetic changes in the genome. (Epigenetic changes are defined as chemical modifications to DNA that can take place without any change in the underlying sequence of As, Gs, Ts and Cs.) The finding may reveal a more general mechanism by which other nutri
'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Anterior Cruciate Ligament (ACL) reconstructions occur more ... material used to create a new ligament may determine ... presenting their work today at the Annual Meeting of ... ). , “Our study results highlight that ... a donor) fail more frequently than using autografts (tissue ...
(Date:7/11/2014)... Re-tearing a repaired knee Anterior Cruciate Ligament (ACL) ... presented today at the American Orthopaedic Society for Sports ... education regarding modifiable risk factors may minimize the chance ... suggests that a few risk factors such as, age, ... to the possibility of re-injury," said lead author, Christopher ...
(Date:7/11/2014)... 11, 2014 With the maturity and ... on comfort, the installation rate of Chinese car electric ... installation rate exceeded 88% and the demand outnumbered 75 ... next few years, Chinese car electric window regulator market ... the market size is expected to exceed 110 million ...
(Date:7/11/2014)... 2014 Wild by Nature, a natural and ... they are opening a fifth store to be located in ... one of the largest selections of wheat and gluten-free products ... disease, these stores have become a one-stop shop for anyone ... sensitivity, and gluten intolerance, is a spectrum of disorders, including ...
(Date:7/11/2014)... July 11, 2014 B. E. Smith, the ... has been retained to lead a national chief nursing ... in Bend, Ore. The top executive search firm ... more than 900 healthcare executives into organizations. , With ... Charles Health System is the largest provider of medical care ...
Breaking Medicine News(10 mins):Health News:ACL Reconstructions May Last Longer With Autografts 2Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 2Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 3Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 4Health News:Wild by Nature Opens New Location 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 3
... Million Grant to Support In-depth, Explanatory Reporting , ... time of uncertainty and transition in the news media, the ... a unique partnership with the California HealthCare Foundation (CHCF) to ... , , Funded by a three-year ...
... , , Practice Abuses ... Group , , WASHINGTON, Sept. 17 ... the bureaucratic abuse of insured patients by for-profit insurance companies, Consumer ... about their use of employees to lobby Congress on company time. ...
... Obama ,plan, as transparent as a Cheney cabinet meeting, says Norquist ... spoke at length about what he called "my plan" before a joint session of Congress. ... several days. By our count he has mentioned the "plan": , , ... of Congress on Sept. 9 , 6 ...
... , , , ... Med" or the "Company") (OTC Bulletin Board: GLOB), an international healthcare ... Med,s Chairman and CEO, will make a major new product announcement ... will be held at The Embassy Suites Boca Raton Hotel, Boca ...
... , Award recognizes local initiatives that ... CHICAGO, Sept. 17 YMCA of the USA today announced ... Casey Foundation FAMILIES COUNT Family Strengthening Award in recognition of their exemplary ... , This is the fourth year that YMCA of the ...
... , DALLAS, Sept. 17 Prostate cancer is the ... in six men being diagnosed with the disease in their lifetime. ... as a strong advocate for prostate cancer awareness, Kimberly-Clark and its ... End Prostate Cancer to help educate men on the risks associated ...
Cached Medicine News:Health News:USC Annenberg and California HealthCare Foundation Join in New Health Care Journalism Venture 2Health News:USC Annenberg and California HealthCare Foundation Join in New Health Care Journalism Venture 3Health News:Consumer Watchdog Says Insurers Must Answer Questions About Use of Employees as Mini-Lobbyists in Congress 2Health News:Where is President Obama's Health Care 'Plan'? 2Health News:Global Med Technologies, Inc.'s CEO to Make Major New Product Announcement the Morning of the LDV Investor Conference and Will Demo the Product on Wednesday, September 23, 2009 2Health News:Global Med Technologies, Inc.'s CEO to Make Major New Product Announcement the Morning of the LDV Investor Conference and Will Demo the Product on Wednesday, September 23, 2009 3Health News:YMCA of the USA and Annie E. Casey Foundation Honor Five YMCAs for Family Strengthening Excellence 2Health News:YMCA of the USA and Annie E. Casey Foundation Honor Five YMCAs for Family Strengthening Excellence 3Health News:YMCA of the USA and Annie E. Casey Foundation Honor Five YMCAs for Family Strengthening Excellence 4Health News:YMCA of the USA and Annie E. Casey Foundation Honor Five YMCAs for Family Strengthening Excellence 5Health News:Video: 'The Depend Campaign to End Prostate Cancer' Brings Sports Legends Together to Celebrate National Prostate Cancer Awareness Month 2
(Date:1/15/2014)... 2014 Most osteoporosis patients want a choice in ... survey* sponsored by Mission Pharmacal Company. The survey, conducted ... online support community, revealed that 74 percent of osteoporosis ... a form other than a pill or a tablet. ...
(Date:1/15/2014)... today announced it has established a relief fund ... that has gripped much of the nation. AARP and its ... support these emergency relief efforts AARP and AARP Foundation will ... to $500,000 in aid. The matching program will be administered ...
(Date:1/15/2014)... 15, 2014 Massachusetts General Hospital (MGH), the ... ) announced today that they have launched a ... therapeutic targets and develop novel therapies for inflammatory ... millions worldwide. The MGH-Broad-Amgen collaboration brings together scientists ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... Encouraging Response in CF Patients - Results Validate ... March 27 The Cystic Fibrosis Foundation,announced today that ... defect in CF, showed promising results in an ongoing ... mutation of CF. The drug is,being developed by Vertex ...
... Research Associates, LLC,announced today that it has issued ... Inc. (TSX: BNC). The full 68-page report,can be ... a Canadian biopharmaceutical company that is committed to,improving ... animals worldwide through,innovative research, novel technologies, and therapeutics. ...
Cached Medicine Technology:Cystic Fibrosis Foundation Announces Positive Early Results for Phase 2 Clinical Trial of VX-770 - an Oral Compound to Treat CF 2Cystic Fibrosis Foundation Announces Positive Early Results for Phase 2 Clinical Trial of VX-770 - an Oral Compound to Treat CF 3Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Bioniche Life Sciences Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Bioniche Life Sciences Inc. 3
... is a semi-rigid system intended for ... Slim-LOC is based on the comprehensive, ... market technology. The Slim-LOC system offers ... Reduced width (16 mm), low profile ...
... Osmium is a cervical plate system ... spine. The implant provides for the ... the bone transplant has consolidated. Optimized ... and bicortical fixation. Maximum purchase also ...
... is designed to meet the clinical challenges ... attached locking mechanism and the choice of ... variable angle screws for ease of implantation ... plate system allows the surgeon the versatility ...
... system is the lowest profile plate clinically ... integrated lock mechanism, which is designed to ... appreciate the narrow width, which decreases the ... system also offers easy to use instrumentation ...
Medicine Products: