Navigation Links
How That Glass of Red Wine Might Help You Live Longer
Date:5/1/2012

By Jenifer Goodwin
HealthDay Reporter

TUESDAY, May 1 (HealthDay News) -- Researchers have found new evidence showing that resveratrol, a compound found in red wine, may play a role in preventing cell aging.

The study in rodents found that when mice had a particular gene -- SIRT1 -- knocked out, or turned off, resveratrol had no effect on them. But tests of muscle tissue in mice with a normal SIRT1 gene that were given resveratrol found that the substance boosted mitochondrial function.

Mitochondria provide the energy that cells need to function. A decrease in mitochondrial energy production has been linked to a variety of diseases, including diabetes and Alzheimer's disease, as well as to the aging process itself, said senior study author David Sinclair, a professor of genetics at Harvard Medical School in Boston.

But don't go reaching for that Chianti yet. Yes, resveratrol is found in the skin of red grapes. But "the amounts we gave to our mice would be like drinking 100 glasses of red wine a day," Sinclair said.

Instead, the goal is to develop synthetic resveratrol compounds that activate SIRT1 and could be taken as medication. "My colleagues are in the middle of developing better molecules that we hope will be medicines that will be used to treat diseases of aging, not to extend lifespan, though that may be a side effect," Sinclair said.

The study is in the May 1 issue of Cell Metabolism.

While previous studies have also suggested that resveratrol may have anti-aging properties, the precise mechanism of resveratrol has been controversial. Several studies, including work with yeast, worms and flies, have found that resveratrol acts on a class of seven genes known as sirtuins and, in human cells, SIRT1 in particular.

But other researchers have argued that resveratrol may work by activating a separate energy pathway called AMPK, which is also related to mitochondrial energy production but does not involve sirtuin genes.

Testing the effect of resveratrol on SIRT1 in mice was difficult, Sinclair said. Mice that have their SIRT1 gene deleted are born with developmental defects and are unsuitable for experiments, he explained.

So Sinclair and two graduate students, Nathan Price and Ana Gomes, worked for years to come up with a method for knocking out SIRT1 in healthy adult mice.

"Our paper found you absolutely require the SIRT1 gene for resveratrol to improve the metabolism of the mice," Sinclair said.

The paper also showed that the AMPK pathway was activated in mice given high doses of resveratrol, yet there was no benefit to mitochondrial function. There was no effect on AMPK in mice given a lower dose of resveratrol.

Sinclair is co-founder and a consultant for Sirtris Pharmaceuticals Inc., which is developing resveratrol-like molecules for use as treatment for age-related diseases. In 2010, according to news reports, the company, which is owned by GlaxoSmithKline, halted clinical trials of resveratrol, but Sinclair said the company continues to develop improved synthetic molecules.

George Vlasuk, CEO of Sirtris, said the new findings offer the "first definitive evidence" for a direct link between SIRT1 and the metabolic benefits of resveratrol.

"The work by [first author] Price et al. strongly supports the basic rationale being pursued at Sirtris, which focuses on the development of small-molecule compounds that directly activate the enzymatic activity of SIRT1 as a new therapeutic approach to many diseases of aging," Vlasuk wrote in an email to the journal.

Philippe Marambaud, an investigator at the Litwin-Zucker Center for Research in Alzheimer's Disease and Memory Disorders at the Feinstein Institute for Medical Research in Manhasset, N.Y, said the new research adds to a body of evidence that resveratrol can potentially combat aging by boosting mitochondrial activity.

"In this study, by using an elegant adult-inducible SIRT1 knock-out mouse model, the authors now provide compelling evidence that SIRT1 is required in vivo [in the animal] for the effect of resveratrol on AMPK activation and on mitochondrial function," Marambaud said.

While studies involving animals can be useful, they frequently fail to produce similar results in humans.

"A mouse model is not a human being, especially when you are genetically manipulating this animal model, you want to be very careful," Marambaud said. "This field has been extremely controversial. We should be very careful about claiming the importance of resveratrol for medical purposes. We have to wait and see, but this study is a big step forward."

More information

The U.S. Centers for Disease Control and Prevention has more on healthy aging.

SOURCES: David Sinclair, Ph.D., professor of genetics, Harvard Medical School, Boston; Philippe Marambaud, Ph.D., investigator, Litwin-Zucker Center for Research in Alzheimer's Disease and Memory Disorders, Feinstein Institute for Medical Research, Manhasset, N.Y.; May 1, 2012, Cell Metabolism


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Dairy Industry Raises a Glass of Milk to Lets Move! Campaign
2. GlassesUSA.com and Cardinal Health in Strategic Partnership
3. Simon Property Group Elects Larry Glasscock to Board of Directors
4. GlassesUSA.com Adds Designer Yoshi Ayaka Eyeglasses to Catalog
5. Glassesshop.com Has Launched Save Your Vision Week Themed Event
6. Hundreds of Georgia School Children to Receive Free Eye Exams and Glasses
7. GlassesUSA.com Launches Virtual Mirror for Glasses on Website
8. GlassesShop Ranked Top 100 Hottest B2C Websites in the United States
9. Introducing a New Generation of Reading and Computer Glasses
10. GlassesUSA.com Launches Section for Prescription Sunglasses
11. Eyeglass Change Might Keep Elderly From Falling
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How That Glass of Red Wine Might Help You Live Longer
(Date:4/29/2016)... Francisco, CA (PRWEB) , ... April 29, 2016 ... ... released fertility clinic data for 2014. Each year, reproductive endocrinologists are required to ... and SART, the main organization of professionals dedicated to the practice of assisted ...
(Date:4/29/2016)... ... April 29, 2016 , ... In its efforts of ... Services continues its successful franchise development and expansion as it welcomes Ferdie Vasquez of ... and administrative experience in his 32 years of working in various industries. He ...
(Date:4/28/2016)... ... 28, 2016 , ... The Dentists Insurance Company ... a letter of intent with Moda to acquire Dentists Benefits Insurance ... Started by dentists 36 years ago, TDIC focuses exclusively on supporting the dental ...
(Date:4/28/2016)... ... April 28, 2016 , ... CastCoverz!, America’s #1 trusted brand ... country's oldest waterproof cast protector . As the largest one-stop, orthopedic shop, ... of daily, night, weatherproof and waterproof covers for most orthopedic devices, including but ...
(Date:4/28/2016)... ... April 28, 2016 , ... The ARRS 2016 ... medical professionals from around the globe who attended a week’s worth of cutting-edge ... April 17 included the introduction of the 2016 ARRS Distinguished Educator, Dr. Gerald ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016   Acsis , a ... that leading IT market research and advisory firm IDC ... the IDC MarketScape: Worldwide Pharmaceutical Track and Trace Software ... report provides an assessment of the capabilities and business ... trace software market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/28/2016)... , April 28, 2016 TapImmune,Inc. ... of innovative peptide and gene-based immunotherapeutics and vaccines for the ... be presenting at the 3rd Annual Growth Capital Expo ... th , 2016 at Caesars Palace in Las Vegas, Nevada.  ... on Wednesday, May 4 th by Dr. John ...
(Date:4/27/2016)... April 27, 2016  Hologic, Inc. (Nasdaq: ... results for the fiscal second quarter ended March ... of $0.24 increased 41.2%, and non-GAAP diluted EPS ... increased 5.8% on a reported basis, and 6.3% ... "We posted another good quarter, highlighted by 14.6% ...
Breaking Medicine Technology: