Navigation Links
How DDT metabolite disrupts breast cancer cells
Date:2/13/2008

Research has shown that the main metabolite of the insecticide DDT could be associated with aggressive breast cancer tumours, but there has been no explanation for this observation to date. Now a report published in the open access journal Breast Cancer Research shows how DDT could act to disrupt hormone-sensitive breast cancer cells.

Michel Aube and colleagues from Universite Laval and Institut national de sante publique in Quebec, Canada have published findings suggesting that DDT's main metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,pi'-DDE), could increase breast cancer progression. They suggest a mechanism whereby p,p'-DDE opposes the androgen signalling pathway that inhibits growth in hormone-responsive breast cancer cells.

The team tested the effect of p,p'-DDE on the proliferation of CAMA-1 cells, a human breast cancer cell line that expresses the estrogen receptor alpha (ERa) and the androgen receptor (AR), either with or without physiological concentrations of estrogens and androgens. They also assessed p,p'-DDE-induced modifications in cell cycle entry and the expression of sex-steroid dependent genes including ESR1 and CCND1, the latter coding for a key protein involved in cell proliferation.

When estrogens and androgens were present in the cell culture medium, increasing concentrations of p,p'-DDE accelerated the growth of CAMA-1 breast cancer cells. p,p'-DDE had a similar effect on the proliferation of MCF7-AR1 cells, an estrogen responsive cell line genetically engineered to over express the AR. Adding the potent androgen dihydrotestosterone together with estradiol to the cell culture medium decreased the recruitment of CAMA-1 cells in the S phase and the expression of ESR1 and CCND1, by comparison with cells treated with estradiol alone. These androgen-mediated effects were blocked with similar efficacy by p,p'-DDE and the potent antiandrogen hydroxyflutamide.

'Our results suggest that in additi
'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nicotine in breast milk disrupts infants sleep patterns
2. Antibacterial chemical disrupts hormone activities
3. Survival differences by race most apparent in advanced stages of breast cancer
4. MRI finds breast cancer before it becomes dangerous
5. Pathway links inflammation, angiogenesis and breast cancer
6. Drop in breast cancer incidence linked to hormone use, not mammograms
7. Breast cancer prevention practices vary across Canada
8. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
9. Acrylamide Wont Raise Breast Cancer Risk
10. New link between estrogen and breast cancer
11. Hypnosis Eases Pain of Breast Cancer Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... March 02, 2015 Four Seasons Resort Maui ... its 25th anniversary this year, having officially opened its doors ... luxury resort is honoring over 70 employees who started on ... from amongst the approximately 400 original employees. The celebration ... Oceanfront Lawn. , This Four Seasons flagship resort, ...
(Date:3/2/2015)... 02, 2015 In light of the ... Xarelto (rivaroxaban) tablets, Ford & Associates Nationwide ... helpful for future users, but may come too late ... taking the drug. The FDA has now included the ... Reactions on Xarelto's label. The term “cytolytic hepatitis” has ...
(Date:3/2/2015)... March 02, 2015 Many mainstream media ... cases of measles. But how much of that news ... their toddlers to prevent measles, but whose youngsters later ... lectures from 150 speakers comprised of professionals, clinicians, researchers, ... recent news stories and questions about the body and ...
(Date:3/2/2015)... California (PRWEB) March 02, 2015 Final ... of the TranStatic Volume 2 from Pixel Film Studios. , ... made exclusively for FCPX,” said Christina Austin, CEO of Pixel ... have in any Final Cut Pro X editors toolbox.” , ... to the next with media altering static scrambling effects from ...
(Date:3/1/2015)... 2015 Security Life Insurance Company ... market, announced the addition of stand-alone individual vision ... Insurance launched today, complete with two plan options. ... the VSP® Vision Care network encompassing a strong ... space. The PrimeStar Select Vision plan will use ...
Breaking Medicine News(10 mins):Health News:Celebrating Four Seasons Resort Maui’s 25th Anniversary 2Health News:Ford & Associates Nationwide Legal Services, A.P.C., Comments on Xarelto Lawsuits Upon FDA Revisions 2Health News:Ford & Associates Nationwide Legal Services, A.P.C., Comments on Xarelto Lawsuits Upon FDA Revisions 3Health News:Ford & Associates Nationwide Legal Services, A.P.C., Comments on Xarelto Lawsuits Upon FDA Revisions 4Health News:Growing List of Professionals Gather for World’s Most Comprehensive Autism Conference in Chicago, May 2015 2Health News:Pixel Film Studios released the TranStatic Volume 2 plugin for Final Cut Pro X today 2Health News:Security Life Insurance Company Launches Individual Vision Insurance Product 2
... PAUL, Minn., Jan. 29 U.S. President Barack ... on human embryonic stem cells (hESC) research and is ... the issue. On Aug. 9, 2001, the Bush administration ... those hESC lines derived before that date. Jonathan ...
... have complications, without ill effects, study finds , , THURSDAY, Jan. ... to babies still in the womb can reduce their post-birth ... growth the way multiple courses can, new research shows. , ... those given a second dose of steroids in utero had ...
... PRO Educational Initiative are AnnouncedPITTSBURGH, Jan. 29 ... electronic patient reported outcomes (ePRO) solutions and ... opened registration for ePROficiency(TM) 2009 -- its ... research professionals can visit http://www.invivodata.com/epro2009 ...
... American businesses take belt-,tightening to new levels to ... a new service to help organizations address one ... EquivaMeds ( www.EquivaMeds.com ) helps self-insured ... helps members analyze their,current medications, identify lower cost ...
... interventions developed by UCSF researchers have been selected ... and Prevention,s 2008 Compendium of Evidence-based HIV Prevention ... Video Doctor and the Healthy Living Projectcomprise two ... 57 rigorously evaluated highly effective HIV prevention programs ...
... BTA stat(R) Test Detects Bladder Tumor Associated Antigen in UrineCORTLANDT ... announce the direct availability of the BTA stat (R) ... (R) test is a point of care technology for the ... antibodies to detect the presence of bladder tumor associated antigen ...
Cached Medicine News:Health News:University of Minnesota's Internationally Recognized Stem Cell Experts Available for Interviews on What Lifting the Federal Funding Restrictions Will Mean to Stem Cell Research and to Patients Who Stand to Benefit 2Health News:Additional Steroid Dose May Help Preemies 2Health News:Additional Steroid Dose May Help Preemies 3Health News:invivodata Opens Registration for Annual Patient Reported Outcomes Conference 2Health News:invivodata Opens Registration for Annual Patient Reported Outcomes Conference 3Health News:CDC recognizes UCSF's research as critical to HIV prevention 2Health News:CDC recognizes UCSF's research as critical to HIV prevention 3Health News:Polymedco Introduces Point of Care Test for Recurrent Bladder Cancer Detection 2
(Date:3/2/2015)... -- ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE MKT: IMUC) today announced that ... 31, 2014 on March 9, 2015. The Company also plans to ... 12, 2015, at 5:00 pm ET. The call will be hosted ...   , , , LIVE CALL:  , , , ... , , , , , ...
(Date:3/1/2015)... , March 1, 2015  An innovative ... chronic migraine sufferers sustained relief of their headaches, ... Society of Interventional Radiology ,s Annual Scientific ... the State University New York Empire State College ... intranasal sphenopalatine ganglion (SPG) blocks to give patients ...
(Date:2/27/2015)... Feb. 27, 2015 Pharmaceutical and biotech marketers ... products for the same indication. This can be a ... to prevent one of their brands from gaining market ... to recent research by benchmarking firm, Best Practices, LLC, ... brands rather than together as part of a franchise. ...
Breaking Medicine Technology:ImmunoCellular Therapeutics to Report 2014 Financial Results on March 9, 2015; a Business Update Conference Call and Webcast is Scheduled for March 12, 2015 2Image-guided treatment shown to break the migraine cycle 2Image-guided treatment shown to break the migraine cycle 3Image-guided treatment shown to break the migraine cycle 4New Report Details How to Expand a Pharmaceutical Product Portfolio without Cannibalizing an Established Brand 2
... Scientific Corporation (NYSE: BSX ) today announced ... 60th Annual Scientific Session of the American College of ... "Twelve-month results from the PLATINUM Workhorse clinical trial ... Everolimus-Eluting Platinum Chromium (PtCr) Stent as compared to our ...
... DIEGO, March 29, 2011 Awarepoint Corporation announced ... at the First Annual Digital Healthcare Innovation Summit ... Intercontinental New York Barclay in New York. Joining Deady on ... of Dell Healthcare Services and Kaveh Safavi, M.D., vice president ...
Cached Medicine Technology:Boston Scientific Announces Its ACC 2011 Schedule 2Boston Scientific Announces Its ACC 2011 Schedule 3Boston Scientific Announces Its ACC 2011 Schedule 4Boston Scientific Announces Its ACC 2011 Schedule 5Boston Scientific Announces Its ACC 2011 Schedule 6Awarepoint CEO Jay Deady to Serve as Panelist at IBF's Digital Healthcare Innovation Summit 2Awarepoint CEO Jay Deady to Serve as Panelist at IBF's Digital Healthcare Innovation Summit 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: