Navigation Links
How DDT metabolite disrupts breast cancer cells
Date:2/13/2008

Research has shown that the main metabolite of the insecticide DDT could be associated with aggressive breast cancer tumours, but there has been no explanation for this observation to date. Now a report published in the open access journal Breast Cancer Research shows how DDT could act to disrupt hormone-sensitive breast cancer cells.

Michel Aube and colleagues from Universite Laval and Institut national de sante publique in Quebec, Canada have published findings suggesting that DDT's main metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,pi'-DDE), could increase breast cancer progression. They suggest a mechanism whereby p,p'-DDE opposes the androgen signalling pathway that inhibits growth in hormone-responsive breast cancer cells.

The team tested the effect of p,p'-DDE on the proliferation of CAMA-1 cells, a human breast cancer cell line that expresses the estrogen receptor alpha (ERa) and the androgen receptor (AR), either with or without physiological concentrations of estrogens and androgens. They also assessed p,p'-DDE-induced modifications in cell cycle entry and the expression of sex-steroid dependent genes including ESR1 and CCND1, the latter coding for a key protein involved in cell proliferation.

When estrogens and androgens were present in the cell culture medium, increasing concentrations of p,p'-DDE accelerated the growth of CAMA-1 breast cancer cells. p,p'-DDE had a similar effect on the proliferation of MCF7-AR1 cells, an estrogen responsive cell line genetically engineered to over express the AR. Adding the potent androgen dihydrotestosterone together with estradiol to the cell culture medium decreased the recruitment of CAMA-1 cells in the S phase and the expression of ESR1 and CCND1, by comparison with cells treated with estradiol alone. These androgen-mediated effects were blocked with similar efficacy by p,p'-DDE and the potent antiandrogen hydroxyflutamide.

'Our results suggest that in additi
'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nicotine in breast milk disrupts infants sleep patterns
2. Antibacterial chemical disrupts hormone activities
3. Survival differences by race most apparent in advanced stages of breast cancer
4. MRI finds breast cancer before it becomes dangerous
5. Pathway links inflammation, angiogenesis and breast cancer
6. Drop in breast cancer incidence linked to hormone use, not mammograms
7. Breast cancer prevention practices vary across Canada
8. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
9. Acrylamide Wont Raise Breast Cancer Risk
10. New link between estrogen and breast cancer
11. Hypnosis Eases Pain of Breast Cancer Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... herpes virus that causes an AIDS-related skin cancer called Kaposi’s ... also attack the internal organs. The virus rarely causes sickness ... weakened immune system as in AIDS. , ,The virus ... Almost 30% to 50% of HIV-infected people who catch herpes ...
... women in the world. There has been some ... of this cancer. Besides surgery there are other options ... therapy. Now at a three-day conference at the National ... on the combination therapy for the cancer.,Dctors have agreed ...
... many non-prescription cough and cold medications. Use of PPA-containing ... by 23 percent. Dr.Ralph I. Horwitz, from Yale University's ... to PPA to the occurrence of hemorrhagic stroke." ... artery wall ruptures and prevents blood flow to the ...
... thyroid hormone replacement prescription drug, levothyroxine sodium (Unithroid) for hypothyroidism ... in the United States by the FDA. , ... wide range of metabolic processes within the body in all ... physical growth and intellectual development. , ,Low levels of ...
... Carlsson, Paul Greengard and Eric Kandel won the ... "signal transduction in the nervous system." The three ... ($915,000) prize for their pioneering discoveries "concerning one ... to as slow synaptic transmission," according to the ...
... pill has been approved by the Food and Drug ... percent effective when women get the shot once every ... ,Lunelle is an alternative to another injectable contraceptive ... many other birth control pills as it has a ...
Cached Medicine News:
(Date:12/17/2014)... 17, 2014 PCCA received the Autism ... http://bit.ly/1382OkS ) program seal for best practices in ... highlights medical practices, materials and goods that meet ... Children affected by autism often have unique ... by ingredients found in food and medicine – ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/bf3b6l/electrocardiogram ) ... Devices - Global Trends, Estimates and Forecasts, 2012-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Global Electrocardiogram Devices (ECG) sector ... North America accounts for nearly ... Europe claims approximately 27% (2018). ...
(Date:12/15/2014)... 2014 BerGenBio AS, a biopharmaceutical ... resistant cancers, today announces that it has raised NOK90 ... new and existing investors. BerGenBio will use ... of its pipeline of innovative cancer therapeutics, in particular ... candidate, BGB324, a first-in-class selective Axl kinase inhibitor, which ...
Breaking Medicine Technology:Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4BerGenBio Completes NOK90 Million Fundraising 2
... (Nasdaq: VRUS ) today announced that it will ... Study of Liver Diseases (AASLD) on Sunday, October 31, 2010 ... Pharmasset,s progress on the programs that are the subject of ... via the internet, log on to the "Events & Presentations" ...
... Calif., Oct. 27 The following statement is being ... Comden, Casselman & Esensten, LLP regarding the ExtenZe class ... has been reached involving the manufacturer of a male ... Williams, et al. v. Biotab Nutraceuticals, Inc., et ...
Cached Medicine Technology:Pharmasset to Webcast an Investor Event from the AASLD Meeting 2Pharmasset to Webcast an Investor Event from the AASLD Meeting 3If You Bought ExtenZe, You Might Receive Money and Benefits from a Class Action Settlement. 2If You Bought ExtenZe, You Might Receive Money and Benefits from a Class Action Settlement. 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: