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Hot Line IV: Late-breaking trials on heart failure and acute coronary syndrome
Date:9/2/2013

AMSTERDAM, The Netherlands The blood pressure lowering drug aliskiren did not improve coronary artery disease when given to patients who had prehypertension, results of the Aliskiren Quantitative Atherosclerosis Regression Intravascular Ultrasound Study (AQUARIUS) reveal.

The findings, reported at the European Society of Cardiology Congress with simultaneous publication in the Journal of the American Medical Association, offer new insight into the value of lowering blood pressure beyond prehypertensive goals, suggested lead investigator Stephen Nicholls MBBS, PhD, Deputy Director at the South Australian Health and Medical Research Institute, Professor of Cardiology at the University of Adelaide and Consultant Cardiologist at the Royal Adelaide Hospital in Adelaide, Australia.

"In the AQUARIUS study, although greater blood pressure lowering was observed in the aliskiren treatment group, we did not observe significant slowing of disease progression," he noted.

"While these findings do not support the use of aliskiren for regression or prevention of progression of coronary atherosclerosis, prespecified exploratory findings in the trial suggests there may be some other potential benefits in patients with pre-existing coronary artery disease and blood pressure levels treated to goalalthough the current clinical findings are inconclusive," he added.

AQUARIUS was a prospective, randomized, multicenter, double-blind clinical trial conducted at 103 centers in Europe, Australia and North and South America.

It included patients aged 35 years or older with angiographic evidence of coronary artery disease, prehypertensive blood pressure at baseline (systolic blood pressure between 125 and 139 mmHg and diastolic blood pressure less than 90 mmHg) and two additional cardiovascular risk factors. Eligibility required a target blood vessel for imaging with at least 20% and less than 50% stenosis.

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Contact: ESC Press Office
press@escardio.org
44-773-005-7146
European Society of Cardiology
Source:Eurekalert

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