Navigation Links
Hospitals vary in monitoring and treatment of children with brain injury, reports study in Neurosurgery
Date:11/11/2013

Philadelphia, Pa. (November 11, 2013) Hospitals vary in management of children with traumatic brain injuryparticularly in monitoring and preventing the harmful effects of increased intracranial pressure (ICP), according to a study in the November issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

The November Neurosurgery also reports on unusual language side effects in patients undergoing electrical brain stimulation for obsessive-compulsive disorder (OCD), and presents plans for a pilot study of a new vaccine therapy for patients with aggressive brain cancers called gliomas.

Variations in Management of Child Brain Injury

Dr. William Van Cleve of University of Washington, Seattle, and colleagues analyzed data on more than 7,000 children with moderate to severe brain injury treated at 156 US hospitals over seven years. The study focused on two evidence- based interventions for brain injury: ICP monitoring, done to measure pressure within the skull; and craniectomy, a surgical procedure to prevent or relieve excessive pressure.

Overall, about 27 percent of children had ICP monitoring, while 12 percent underwent craniectomy. Rates of both interventions varied significantly between hospitals. Children treated at combined pediatric adult/trauma centers were one-fifth less likely to undergo ICP monitoring, compared to those at adult-only centers.

The variation remained significant after adjustment for other factors. The researchers call for further studies to understand "the institutional and regional factors associated with variability in the use of these invasive but potentially outcome-modifying technologies."

Brain Stimulation for OCD Leads to 'Foreign Accent Syndrome'

A. Rosaura Polak, MSc, of University of Amsterdam, Academic Medical Center and colleagues report on an unusual effect of deep brain stimulation in two Dutch patients with OCD. Now commonly used for Parkinson's disease, brain electrical stimulation has also emerged as a new treatment for treatment-refractory OCD that doesn't improve with medications. In both patients, OCD symptoms improved with brain stimulation.

However, there were also some unexpected language-related side effects. Both patients began speaking in a different accent, either in an accent that was common in their native region or with a more distinguished pronunciation. The changes were similar to a rare "foreign accent syndrome" reported in stroke patients.

Other changes included a more "aggressive vocabulary," such as swearing; and "hypomanic" behaviors, such as hyperactivity and excitability. In both patients, the language changes persisted after adjustment to the brain stimulation patterns. The results suggest that deep brain stimulation for OCD "influences not only mood and behavior but also linguistically related circuitry," the researchers write.

Plans for Trial of New Vaccine for Recurrent Gliomas

John Goldberg and colleagues of University of Miami Miller School of Medicine outline plans for a clinical pilot study to assess a "dendritic cell vaccine" for patients with gliomas that recur after surgery. The vaccine consists of the patients' own immune cells, mixed with fragments of destroyed tumor cells.

The goal of the vaccine is to stimulate the patients' own immune system to attack the tumor cells. Similar dendritic cell vaccines have shown promising results in previous studiesin one small study, one-third of patients were alive and free of brain cancer at five years' follow-up.

Before vaccination, patients will receive an approved topical medication (imiquimod) that appears to promote immune activity of dendritic cells. The authors plan to enroll 20 patients over two years. If the results show promising effects on patient survival with acceptable side effects, it will pave the way for larger studies of approaches using dendritic cell vaccines to reduce the risk of recurrence after surgery for glioma.


'/>"/>

Contact: Connie Hughes
connie.hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Related medicine news :

1. Higher-spending hospitals have fewer deaths for emergency patients
2. Heart Attack Survival Varies Widely Among Hospitals, Study Finds
3. In Some Brain Bleeds, Patients Do Better at High-Volume Hospitals
4. Fewer prostate cancer surgery complications found in teaching hospitals with fellowship programs
5. Urban Hospitals May Act as Breeding Ground for MRSA
6. University Hospitals Case Medical Center experts present at ASCO Annual Meeting
7. Under pressure from Medicare, hospitals hold more seniors for observation
8. Ethics should drive health policy reform, especially with physician-owned specialty hospitals
9. Hospitals communication during residency matching may put stress on OB-GYN doctors-in-training
10. Becker's Hospital Review Shares 50 Top Grossing Hospitals in the Country
11. Lighthouse Worldwide Solutions Now Monitors Air Quality in Hospitals and Operating Rooms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... Cheerag D. Upadhyaya , M.D., ... Bloch Neuroscience Institute (SLMBNI), part of Saint Luke’s Health System . Dr. ... Cheerag D. Upadhyaya, MD. M.Sc., FAANS joins Stanley P. Fisher, M.D., who ...
(Date:7/24/2017)... Angeles, California (PRWEB) , ... July 24, 2017 ... ... building fire in Oakland, California effectively destroyed the construction site and threatened numerous ... a July 7th article on NBCLosAngeles.com. Los Angeles Area consulting ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... initiatives designed to promote awareness for Topricin’s revolutionary, natural, after-burn skin care product, ... of the leading causes of long term skin conditions, including cancer. In ...
(Date:7/24/2017)... ... July 24, 2017 , ... The 2017 NCSL International Workshop ... theme focuses on the new ISO/IEC 17025 standards. This marks the first time ... and calibration will be changed. , As an exhibitor, METTLER TOLEDO will ...
(Date:7/24/2017)... Napa, Calif. (PRWEB) , ... July 24, 2017 ... ... massager, on Tuesday received the prestigious StorErotica “Consumer’s Choice” Award, for favorite sex ... presented at the 11th annual StorErotica Awards to be consumer voted. The Magic ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... 2017  MedX Holdings, Inc., the manufacturer and global ... rehabilitation equipment, today announced the national roll out of ... the gold standard for the treatment of low back ... equipment. How it ... or practice who prescribe the MedX Home Back Machine ...
(Date:7/13/2017)... Products, a leader in medical product innovation and global patient care, ... hospice patient care. ... Centurion Medical Products ... management and emotional comfort are part of a hospice,s primary mission. ... unneeded emergency department admission due to severe fecal impaction. One of ...
(Date:7/12/2017)... , July 12, 2017  Eli Lilly and Company ... agreement with generic companies to resolve pending patent litigation in ... Virginia regarding the Cialis ® (tadalafil) ... on April 26, 2020. As part of the agreement, Cialis ... September 27, 2018. "The unit dose patent for ...
Breaking Medicine Technology: