Navigation Links
Hospital for Special Surgery investigators receive National Football League grant for PRP research
Date:9/11/2012

Researchers at Hospital for Special Surgery have been awarded a $100,000 grant from the National Football League (NFL) Charities to research the use of platelet-rich plasma (PRP) and stem cells as treatments for tendon injury and degeneration. For years, PRP has been used to improve healing in various sports injuries, but there is little evidence of its efficacy. Tendon overuse injuries are commonly seen in NFL players and recreational athletes, and new treatments are needed.

"We don't have a treatment that works 100 percent of the time, so there is room for improvement," said Scott Rodeo, M.D., co-chief of the Sports Medicine and Shoulder Service for Hospital for Special Surgery in New York City. "Many people are weekend warriors and they suffer from tendon overuse injuries. Hopefully, our study will be able to help a lot of these people." Dr. Rodeo will be heading up the research. He has been associate team physician for the New York Football Giants since 2000.

The results of the research could lead to the development of an effective therapeutic strategy for tendinopathy that may allow NFL players to return to competition more quickly. It may also lead to a decrease in complications related to tendinosis, such as tendon ruptures.

Tendinosis is caused by repetitive microtears in the connective tissue in and around the tendon along with a failure of the body to mount a full healing response. Over time it can lead to pain, reduced tensile strength and chance of tendon rupture.

The grant money will be used to investigate how degenerated tendons respond to PRP and bone marrow-derived stem cells as well as if these two treatments will be synergistic if they are combined. Researchers will test these treatments in a preclinical model of tendon injury and degeneration. Among the goals of the research are to examine the structural and mechanical properties of the treated tendon tissue and to see how it responds to PRP and stem cells.

In recent years, physicians have found that some, but not all, patients with tendon disorders respond to treatment with PRP. PRP contains cells and growth factors that may stimulate healing of bone and soft tissue. Researchers surmise the mixed results may be caused by variations in preparation, timing, dosage and delivery of platelets, or differences in bioactivity. Different PRP preparations contain different amounts of cell and growth factors, and the researchers speculate that the negative studies may have used PRP preparations with low bioactivity. To test this theory, researchers will test the bioactivity levels of the preparations used. It is also unclear whether PRP treatments actually help heal the tendon structure or just ameliorate the pain. An examination of tissue should provide an answer to this question.

"We don't really understand how PRP affects tendon structure after we place it into patients. Some individuals get pain relief while others do not. The reported clinical results are mixed, " said Richard Ma, M.D., an orthopedic surgery fellow in the Sports Medicine and Shoulder Service at Hospital for Special Surgery and co-principal investigator for the study. "The advantage of a preclinical research model is we can not only evaluate the effects of PRP on tendon architecture after injury, but we can also evaluate how it might improve the structural strength of these tendons.

Similar to PRP, studies using stem cells to treat tendon disorders have also yielded conflicting results. HSS researchers hope their experiments can tease out how this treatment impacts tendons. "Cell therapies such as bone marrow stem cells are attractive because it may provide the necessary stimulus to overcome the unfavorable biologic microenvironment in chronic tendon degeneration," said Dr. Ma. Stem cells have the capability of differentiating into diverse specialized cell types.

"We hope the results of our study will identify the important parameters that might improve the efficacy of PRP and stem cell treatments," said Dr. Ma. "Despite both treatments being readily clinically used, there is still a great deal we do not understand about PRP, stem cells, and how to optimize its composition to improve its efficacy for all patients. With our research proposal, we are hoping to address some of these questions that we have not been able to answer with human clinical studies."

Dr. Rodeo is also a team physician for USA Olympic Swimming. He just returned from the summer games in London, England.

The NFL Charities support medical research that enhances the body of scientific knowledge that will ultimately benefit all who are actively involved in competitive sports and recreational athletic activities.


'/>"/>
Contact: Phyllis Fisher
phyllis.fisher@gmail.com
212-606-1724
Hospital for Special Surgery
Source:Eurekalert

Related medicine news :

1. Higher-spending hospitals have fewer deaths for emergency patients
2. Predictors identified for rehospitalization among post-acute stroke patients
3. More Smog Might Mean More Hospitalizations
4. After Hospitalization, Men More Likely to Show Up in ER
5. Choosing the right hospital may save your babys life
6. Heart Attack Survival Varies Widely Among Hospitals, Study Finds
7. In Some Brain Bleeds, Patients Do Better at High-Volume Hospitals
8. Rate of Hospitalizations for Stroke Has Declined in U.S.
9. Hospital readmission rates linked to availability of care, socioeconomics
10. Availability of Beds, Poverty Drive Costly Hospital Readmissions
11. Inhaled Steroids Lead to Big Drop in Asthma Deaths at Texas Hospital: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... Digital Scientists, a software innovation ... the opening of a Greenville, South Carolina location. The lab has set ... Greenville. , “We’ve been working with South Carolina clients for years from our office ...
(Date:3/24/2017)... Lake Orion, MI (PRWEB) , ... March 24, ... ... providing insurance assistance, financial planning, and related services to families and business owners ... charity initiative aimed at feeding regional families struggling with financial difficulties. , The ...
(Date:3/24/2017)... ... March 24, 2017 , ... On June 9, 2017, ... Claims Litigation seminar in Chicago, Illinois. She will present on: , Filing ... litigated under ERISA involve claims for long-term disability benefits. This session will ...
(Date:3/24/2017)... ... March 24, 2017 , ... Judy Buchanan, co-owner of Serenity ... MD. Judy says, “I am passionate about sharing Reiki as a holistic, complementary ... and challenging time.” , A Certified Medical Reiki™ Master trained by Raven Keys ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Adventures of Joey, The Dog Who Barks ... lives his life to the fullest, as God intended. “The Adventures of Joey, The ... mother and grandmother pursuing her passion for writing, especially about truth and human behavior. ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017 FinancialBuzz.com News Commentary   ... Medical cannabis products around the ... Inc., projects that the global medical cannabis market will reach a value ... is a major market for the new growing industry. By the end ... legally buy and sell medical cannabis. More conservative states like ...
(Date:3/24/2017)... A ReportsnReports.com report says, over the recent ... the global sales of Adcetris and Kadcyla have been witnessing rapid ... conjugates market is driven by large number of ADC drugs in ... offered by ADCs. ... Browse 3 Tables and 94 Figures, 10 Major Company Profiles, spread ...
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... Global Strategic Business Report" report to their offering. ... The report provides separate comprehensive analytics for ... Europe , Asia-Pacific , ... are provided for the period 2015 through 2022. Also, a six-year historic ...
Breaking Medicine Technology: