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Hospira's Precedex(R) Phase IV Study Published in the Journal of the American Medical Association
Date:2/2/2009

ectiveness of different sedative agents for important clinical outcomes.

"Through this clinical research for Precedex, Hospira is working to provide nurses, physicians and pharmacists with data to support a potential new sedation strategy for management of these complex and critically ill patients," said Paula Bokesch, M.D., global medical director, Global Medical Affairs - Drug Development, Hospira. "Hospira is committed to the research and development of products that improve patient care."

Precedex Indications and Safety Information

Precedex (dexmedetomidine hydrochloride) is Hospira's proprietary I.V. sedative, and it is a relatively selective alpha-2-adrenoceptor agonist. In the United States, it is the only drug in its class (alpha-2-agonists) approved for continuous I.V. sedation of initially intubated and mechanically ventilated patients in the intensive care setting for use up to 24 hours. It can be used before, during and after extubation.

Due to the known pharmacological effects, patients should be continuously monitored while receiving Precedex. Precedex should only be administered by persons skilled in the management of patients in the intensive care or operating room setting. Clinically significant bradycardia and sinus arrest episodes in young, healthy volunteers with high vagal tone or with different routes of administration including rapid intravenous or bolus administration have been reported. Hypotension and/or bradycardia may necessitate intervention and may be more pronounced in hypovolemic patients and in patients with diabetes mellitus, chronic hypertension, and the elderly. Co-administration with other vasodilators or negative chronotropic agents: Use with caution due to additive pharmacodynamic effects. Transient hypertension has been observed primarily during the loading dose. The most common treatment-emergent adverse reactions occurring in greater than 2 perc
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SOURCE Hospira, Inc.
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