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Hospira's Precedex(R) Phase IV Study Published in the Journal of the American Medical Association
Date:2/2/2009

cent in Precedex-treated patients vs. 76.6 percent in midazolam-treated patients. Median time to removal from mechanical ventilation was 3.7 days in the Precedex-treated patients vs. 5.6 days in the midazolam-treated patients, a difference of 44 hours. Precedex-treated patients were more likely to develop bradycardia, or slow heartbeat, but had a lower likelihood of tachycardia (fast heartbeat) or hypertension that required treatment.

The study design used in this phase IV trial incorporated new standard elements of sedation practice, including a light-to-moderate sedation target, delirium assessment, and study drug titration or interruption every four hours and as part of a daily arousal assessment.

"This multicenter study is one of the largest to compare two different sedatives for use in the ICU in a randomized and blinded design," said Richard R. Riker, M.D., director of critical care research, Division Pulmonary and Critical Care Medicine, Maine Medical Center. "Patients who received Precedex were extubated sooner and had a lower prevalence of delirium. I expect that patients requiring long-term sedation, their families and healthcare providers will welcome the results of this trial."

There are more than 5 million patients treated annually in the ICU(1). In 2003, there were nearly 300,000 prolonged mechanical ventilation discharges in the United States at an annual aggregated hospital cost of more than $16 billion. At a cost of more than $1,500 per patient-day(2), mechanical ventilation represents a significant contribution to overall expenses in the intensive care setting and drives a disproportionate share of resource utilization.

Providing sedation for patient safety and comfort is an integral component of bedside care for nearly every patient in the ICU, and practice guidelines for sedation in the ICU have identified the need for well-designed randomized trials comparing the eff
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SOURCE Hospira, Inc.
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