Navigation Links
Hormone replacement in joint fluid has potential regenerative effect

German researchers determined that concentrations of the sex hormones, testosterone in men and estrogen in women, may have a positive effect on the regenerative potential of cartilage tissue. The study suggests hormone replacement in the joint fluid of men and women might be beneficial in treating late stages of human osteoarthritis (OA) by regenerating damaged tissue. Details of this evidence-based study appear in the April issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

Free moving (diarthrodial) joints, such as the knee and hip, produce smooth and painless limb movement when there is adequate transmission of forces between the bones and joint (articular) cartilage. Disturbances in joint architecture due to trauma, abnormal load, endocrine diseases (diabetes, hypothyroidism) or inflammatory conditions may result in OA. Worldwide estimates say 9.6% of men and 18% of women 60 years or older have OA symptoms and the World Health Organization (WHO) projects that by 2020, OA will be the fourth leading cause of disability.

Nicolai Miosge, M.D., Ph.D., and colleagues from the August University in Goettingen, Germany examined the regenerative potential of chondrogenic progenitor cells (CPCs) that are present in arthritic tissue during the late stages of OA. The research team speculated that these CPCs might be influenced by sex steroids, and therefore hormone replacement therapy directed to the joint fluid could be beneficial in restoring damaged tissue. Tissue samples from 372 patients who underwent total knee replacement were analyzed. The mean age was 71 years of age for men and 72 years for women, with women representing 64.25% of participants.

Estrogens are known to influence bone metabolism and researchers found that 17β-estradiol (E2), which increases calcium deposition in both sexes, was present in the joint fluid of study participants. CPCs positive for estrogen receptors (ERα and ERβ) as well as androgen receptors were present in the OA tissue as well. Both estrogen and testosterone influenced the expression of all 3 receptor genes and the CPCs by regulating gene expression.

Researchers found late-stage OA cartilage populated with elongated cells that were not present in healthy connective tissue. Upon investigation of the elongated cells, the team identified a unique progenitor cell population (CPCs). "We were able to isolate CPCs in 95.48% of female patients and 96.97% of male patients, making these cells a good target for future therapeutic intervention for a very large number of OA patients," Dr. Miosge said. "Hormone replacement therapy in joint fluid may help mitigate the effects of OA and further investigation is needed," concluded Dr. Miosge.


Contact: Dawn Peters

Related medicine news :

1. Experts Issue Warning on Prostate Hormone Therapy
2. Stress Hormone Could Be Key to Alcoholism
3. Treating Low Growth Hormone in Childhood May Thwart Later Ills
4. More blood vessels in hormone-resistant prostate tumors
5. Fat Hormone May Protect Against Alzheimers
6. New human reproductive hormone could lead to novel contraceptives
7. Prostate Hormone Therapy May Up Heart Risks
8. Pioneering Hormone Therapist to Host Free Health Seminar
9. Hormone May Prevent Aggressive Breast Cancer
10. Bonding Hormone Might Help Some With Autism
11. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
Post Your Comments:
(Date:11/30/2015)... ... December 01, 2015 , ... The ... a 2015-2016 inductee into its VIP Woman of the Year Circle. She is ... leading networking organization exclusively for professional women, boasting 850,000 members and over 200 ...
(Date:11/30/2015)... ... December 01, 2015 , ... Live Very Well ... vision insurance plans on . The multi-carrier insurance exchange platform offers ... products, allowing consumers to compare, quote and match plans to meet their needs. ...
(Date:11/30/2015)... ... 2015 , ... Stress, anxiety, illness, infection or even a need for eyeglasses ... Heather Spader, MD, a new pediatric neurosurgeon at Joe DiMaggio Children’s Hospital in Hollywood, ... tumors. , “Bad headaches that don’t go away, that don’t have any ...
(Date:11/30/2015)... ... , ... MOSI recently added two state-of-the-art augmented reality (AR) experiences from INDE ... their collection of interactive exhibits within the Kids In Charge! building. In collaboration with ... get closer than ever to a range of animals as they drink, sleep and ...
(Date:11/30/2015)... ... November 30, 2015 , ... On Saturday, October 24th, 2015, ... held an annual fundraising event, a 5K walk known as “Making Strides Against Breast ... substance abuse which is also located in Battle Creek, joined in for this campaign ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015 ... adds a 2015 publication on ... 2015 with comprehensive analysis of recent ... deal types, such as Mergers & ... . --> ...
(Date:11/30/2015)... 30, 2015  The fee-for-service reimbursement model ... medical imaging is on its way to ... payer-provider contracts are set to phase out ... alter provider-vendor relationships. The shift to value-based, ... new purchasing frameworks in the medical imaging ...
(Date:11/30/2015)... MOUNTLAKE TERRACE, Wash. and ST. ... Cross and Express Scripts (NASDAQ: ESRX ) today ... benefit agreement. The partnership, which began in 1999, will ... --> --> After evaluating pharmacy ... process, Premera concluded that Express Scripts continues to offer ...
Breaking Medicine Technology: