Navigation Links
Hormone refractory prostate cancers more likely to spread to other organs
Date:2/20/2008

Prostate cancers that are resistant to androgen deprivation therapy are more invasive and more likely to spread to other organs than androgen dependent prostate cancers, UCLA cancer researchers have found.

Virtually all prostate cancers are androgen dependent at first, but they progress and become resistant over time. These hormone refractory or castration resistant cancers can grow despite surgical or medical therapies that deplete testosterone. The UCLA study is the first to link that progression with the cancers tendency to spread to other organs. The findings could change the way some prostate cancers are treated, spurring earlier use of hormone therapy to prevent the cancers spread, said Dr. Robert Reiter, a professor of urology, a researcher at UCLAs Jonsson Cancer Center and senior author of the study.

Published in the Feb. 15 issue of the journal Cancer Research, the study makes the connection between androgen receptor and the spread of prostate cancer as well as the progression to androgen independence. Previous studies have shown that the androgen receptor is responsible for the growth of hormone refractory prostate cancer. However, no one has associated the spread of prostate cancer to the androgen receptor, Reiter said.

We started noticing that the castration resistant prostate cancer models in the lab seemed to express genes that are typically associated with the spread of cancer, Reiter said. We began to ask what cell signaling pathways might be responsible. We looked at the androgen receptor and were surprised to find that it was not only overexpressed in castration resistant cancers but also in invasive cancers that still relied on androgen to grow.

The study found that overexpression of the androgen receptor was critical to the cancer becoming more invasive. If a therapy could be found that blocked overexpression of the receptor, it might prevent the spread of certain prostate cancers.

Traditionally, doctors dont like to use hormone treatment which stops the production of testosterone - early on in the treatment of prostate cancer because of the harsh side effects, which can include hot flashes, osteoporosis and sexual dysfunction. In the past, doctors have waited until the cancer spread to prescribe hormone therapy, Reiter said.

This study may provide additional scientific rationale to support the recent trend that giving hormone treatment early on is better than waiting, Reiter said. Early hormone treatment in this group of men might allow them to live longer. High levels of androgen receptor in the primary tumor might also predict which cancers are more likely to spread despite initial surgery or radiation.

This strategy could be particularly effective in high risk men, those with large primary tumors, high Gleason scores and those that have lymph node involvement at diagnosis.

Prostate cancer is the most common cancer in men in the United States. This year alone, more than 218,000 men will be diagnosed with prostate cancer. About 27,000 men will die from the disease.

Reiter and his team will next seek to understand the mechanism by which androgen receptor overexpression is causing the cancer to spread. If they can uncover the mechanism, they might find new and better targets for drug therapy in addition to targeting the androgen receptor.


'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Newly discovered role of thyroid hormone during pregnancy
2. Stress hormone impacts memory, learning in diabetic rodents
3. Moving beyond tamoxifen: Drug discovery and the future of selective hormone receptor modulators
4. Diabetes, Growth Disorders Drive Sales of Pediatric Hormone Drugs
5. Sex Hormones Dont Seem to Affect Prostate Cancer Risk
6. Hormone Therapy Only Helps Some Older Men With Prostate Cancer
7. FDA Warns Against Bio-Identical Hormone Therapy
8. FDA Asserts New Policy to Restrict Womens Access to Bioidentical Hormones
9. Just 4 months of hormone therapy can delay prostate cancer growth by up to 8 years
10. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
11. Hormone may be new drug target for preventing lymphedema, tumor spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... , ... March 27, 2017 , ... New patients who ... replace their missing teeth can now have them placed by Dr. Manju Kejriwal, with ... i-CAT® Cone Beam technology to increase the accuracy of each dental implant placement. The ...
(Date:3/27/2017)... ... 27, 2017 , ... This is the second major release ... in 2014. It is the culmination of collaborative efforts by members of the ... Organizational Member Zato Health co-funded the ONC certification and provided key technical support ...
(Date:3/27/2017)... , ... March 27, 2017 , ... Buzzies parent company, ... 10 for Rent the Runway Foundation and UBS’ Project Entrepreneur. Mayo will present her ... April 8. , Project Entrepreneur’s second annual venture competition ignites bold ideas by ...
(Date:3/27/2017)... ... 2017 , ... The Case Management Society of America (CMSA) will install six ... CMSA’s membership has elected their upcoming President-Elect, Secretary, Treasurer and two Directors to serve ... VA Advisory position has also been added to the BOD, per an appointment made ...
(Date:3/27/2017)... Orion, Michigan (PRWEB) , ... March 27, 2017 ... ... results. The comprehensive weight management program at Women’s Excellence will help patients ... initial evaluation and physical exam. The specialists at Women's Excellence will measure ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 27, 2017 /PRNewswire/ - INVICTUS MD STRATEGIES CORP. ("Invictus ... Invictus MD is pleased to announce it has received ... on the TSX Venture Exchange.  Receiving ... year of significant achievements for Invictus-MD. Some of which ... at AB Laboratories Inc. ("AB Labs"), a Licensed Producer ...
(Date:3/27/2017)... YORK , March 27, 2017 ... colors as the NASDAQ Composite closed the trading session ... lower; and the S&P 500 was down 0.08%. US ... nine sectors finishing the day in green. Pre-market today, ... Wright Medical Group N.V. (NASDAQ: WMGI), Amedica Corporation (NASDAQ: ...
(Date:3/27/2017)... YORK , March 27, 2017 /PRNewswire/ ... technology platform for value-based precision medicine, today ... collaboration with Novartis Pharmaceuticals Corporation to help ... cancer patients. As part of ... previous announced collaboration entered into January 2016, ...
Breaking Medicine Technology: