Navigation Links
Hormone reduces risk of heart failure from chemotherapy
Date:8/4/2011

Recent studies have shown that the heart contains cardiac stem cells that can contribute to regeneration and healing during disease and aging. However, little is known about the molecules and pathways that regulate these cells. Now, a new study utilizing a heart failure model is providing insight into one way to coax the cardiac stem cells into repairing the damaged heart. The research, published by Cell Press in the August 2011 issue of the journal Cell Stem Cell, finds that low doses of erythropoietin (EPO), a hormone best known for controlling the production of red blood cells, might reduce the risk of heart failure associated with some anticancer therapies.

Chemotherapy with doxorubicin (DOX) has been used effectively to treat a broad range of cancers but is limited because of severe side effects, most notably heart failure. Likewise, blocking STAT3, an important factor that drives tumor growth has been associated with heart failure. To learn more about the activity of cardiac stem cells under these conditions, senior study author, Dr. Denise Hilfiker-Kleiner from the Medical School Hannover in Germany, and colleagues studied cardiac stem cells in mice that were lacking the STAT3 gene in their hearts or were treated with DOX.

Dr. Hilfiker-Kleiner and colleagues observed that in both groups of mice, cardiac stem cells displayed an impaired ability to form new blood vessels which are essential for oxygen delivery to the heart muscle. Both sets of mice produced less EPO in their heart muscle than untreated controls. The researchers went on to demonstrate that EPO binds to cardiac stem cells and is required to maintain the signaling molecules necessary for production of new blood vessels. Importantly, when the mice were given a synthetic EPO derivative at a low dose which did not affect red blood cell production, stem cell differentiation to blood vessel cells was restored and cardiac function was preserved. "Short-term EPO administration at low doses seems an attractive avenue to pursue for protecting the heart during chemotherapy and might have broader applications in cardiac regeneration," concludes Dr. Hilfiker-Kleiner.


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Pioneering Hormone Therapist to Host Free Health Seminar
2. Hormone May Prevent Aggressive Breast Cancer
3. Bonding Hormone Might Help Some With Autism
4. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
5. Early On, Hormone Therapy May Raise Womens Heart Risks
6. Testicular Cancer Survivors May Have Hormone Deficiency
7. Stress hormone, depression trigger obesity in girls
8. Buy HGH Website Educates Consumers on the Pros and Cons of Human Growth Hormone Supplements
9. Hormone thought to slow aging associated with increased risk of cancer death
10. Hormone Outperforms Insulin in Diabetic Mice
11. High Hormone Level Linked to Cancer Death in Older Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... 2016 , ... New Brunswick, New Jersey: This year marks Children’s Specialized Hospital ... To commemorate the anniversary, the hospital has themed the milestone “Hats Off” and kicked ... Hospital Foundation on Saturday, May 21, at Johnson Park in Piscataway, New Jersey. ...
(Date:5/24/2016)... Bahama (PRWEB) , ... May 24, 2016 , ... Regenerative ... Such breakthroughs in adult stem cell therapy technology, protocols and patient results as have ... emerging field to become a more accessible standard of care for patients worldwide. , ...
(Date:5/24/2016)... Linda, CA (PRWEB) , ... May 24, 2016 , ... ... will house the new adult hospital and expanded Children’s Hospital. Over 3,000 people looked ... 22. , Check out the event photo slidehsow. , During the program, ...
(Date:5/24/2016)... Fla. (PRWEB) , ... May 24, 2016 , ... Boyd ... the Concealed Delivery Unit® (CDU), a groundbreaking new product for pediatric dentistry , ... Pediatric Dentistry in San Antonio, TX May 26-29. The Concealed Delivery Unit keeps dental ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... A newly ... rely heavily on their access to trusted resources, both in face-to-face interactions and online. ... Men of Color,” researchers concluded that the creative use of mobile digital devices can ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Los innovadores de COMBO[TM], ... introduce catéteres para la intervención de extremidades inferiores ... global especializada en el suministro de soluciones vasculares ... incluyendo productos para tratar la enfermedad arterial periférica. ... los dispositivos de primera entrada de la compañía ...
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 Dutch ... their best practices around the world and treat patients on a ... Africa , Asia and the ... streaming with instant messaging and networking in a totally secure environment. ... Frontieres in a war zone working together with a surgeon at ...
(Date:5/23/2016)... , May 23, 2016 ... across 163 pages, profiles 12 companies and the Paclitaxel ... and figures on the industry and its players. ... is comprehensive in nature, details the current state of ... industry including definitions, classifications, applications and industry chain structure. ...
Breaking Medicine Technology: