Navigation Links
Hormone promises to keep joint injuries from causing long-term osteoarthritis
Date:9/12/2009

s from undergoing maturation, and stimulates their proliferation, preserving larger pools of cartilage cells in the joint. Signaling molecules like PTH have their effect in the body by interacting with specifically shaped proteins on the cell surfaces called receptors. PTH docks into its receptors, like a ship coming into port, which changes the shape of the dock such that biochemical signals are sent.

The authors of the current study observed that chondrocytes within injured and degenerating cartilage have more PTH type 1 receptors on their surfaces. This makes them especially sensitive to the PTH signal that prevents harmful chondrocyte maturation into bone in the joint cartilage. Thus, PTH therapy should increase the cartilage supply exactly where cartilage loss is causing disease.

"Right now physicians have no way to bring back cartilage in patients who have lost it to osteoarthritis," said Randy Rosier, M.D., Ph.D., professor within the Department of Orthopaedics and Rehabilitation at the University of Rochester Medical Center. "Our current results, at least in mice, show that we can inhibit cartilage degeneration and improve the volume of cartilage in diseased joints. It's remarkable enough that this compound delays the loss of cartilage, but these results show it also may be able to restore, at least to some extent, cartilage in already degraded joint surfaces."

Researchers examined the impact of a daily dose of Forteo/teriparatide, manufactured by Eli Lilly, and a generic version of teriparatide made by Sigma on the progress of OA following injury in study mice.

Experiments established a five-fold increase in PTH type 1 receptor expression in the articular cartilage of mice with injury-related osteoarthritis when compared to healthy cartilage. Injury triggers genetic mechanisms in an attempt to begin repairs, a repair response that may be responsible for the increase in PTH receptor in the joint. This in turn makes
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Drop in breast cancer incidence linked to hormone use, not mammograms
2. Researchers develop long-lasting growth hormone
3. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
4. Less than one-third of women aware of landmark hormone therapy study, Stanford researcher finds
5. Most Women Unaware of Hormone Replacement Study
6. Survival data presented from phase II study of hormone-resistant prostate cancer patients
7. Hormone May Play Key Part in Creating Memories
8. Hormone Therapy for Prostate Cancer Linked to Heart Risks
9. Wyeth to Appeal Nevada Hormone Therapy Trial Verdict
10. New data on hormone therapy must lead to re-evaluation of official guidelines
11. From Hot Flashes to Breast Cancer: ZRT Labs Hormone Testing Catches On As Women Consider Safer, More Natural Options.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... November 24, 2014 Mental health ... day. They break up families, ruin careers, and ... hope for those that suffer,” says Hardy ... is showing that our specialized nutritional treatments can ... appear on “Mind Over Matter”, the premiere episode ...
(Date:11/24/2014)... Dr. Michael Kettel , a leading fertility expert ... to discuss egg freezing as a viable and increasingly accessible ... news recently, with new company benefits at Facebook and Apple ... “[The companies] see it as a way to take care ... Says Dr. Kettel. , Up until a few weeks ago, ...
(Date:11/23/2014)... The report, “Market Snapshot: Aesthetic ... - Asia-Pacific” provides quantitative analysis of the three ... invasive body contouring devices, non-invasive body contouring devices ... size data by revenue and volume over the ... Japan, South Korea, Australia and India. It uses ...
(Date:11/23/2014)... News) -- The holidays can be a challenge for ... trigger major meltdowns, an expert says. "Holidays with ... but when you have children with special needs, some ... professor at University of the Sciences in Philadelphia, said ... let your hosts or visitors know what special requirements ...
(Date:11/23/2014)... New York, NY (PRWEB) November 23, 2014 ... over the past month in a federal litigation involving ... over similar diabetes medications, Bernstein Liebhard LLP reports. ... that 566 claims over a class of Type 2 ... been filed in the U.S. District Court, Southern District ...
Breaking Medicine News(10 mins):Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 3Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 3Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 4
... in Better Health ... Outcomes, Reduced Costs, ... announced an agreement to renew their four-year services,agreement and expand ... enhancement services to Independence Blue Cross,members., Under the new, ...
... on Dangers of Parental Smoking in Homes and Cars, ... - almost half of the world,s youth - breathe air ... the home or the,car subject others to a dangerous mix ... windows are open. Second-hand smoke,exposes children to chronic health risks:, ...
... PowerTerm(R) WebConnect for, Secure Remote Access to Windows Terminal ... ... CLOSTER, N.J., Jan. 29 Ericom Software, a ... the,Brant County Health Unit, a major Canadian community health ...
... Calif., Jan. 29 The Coalition for,Pulmonary Fibrosis ... its,new Chief Executive Officer. Michon has more than ... a key area of importance in,leadership for non-profit ... the,CPF,s next phase of growth, including expanding CPF ...
... Key Management Posts as Senior Vice Presidents, ... AGP ) today announced the hiring of ... management positions: Linda,Whitley-Taylor has been named Executive Vice ... as Senior Vice President, Senior,Litigation Counsel; and William ...
... research pioneer Professor Robert A Weinberg is the first recipient ... by Swedish scientists Georg and Eva Klein. The prize is ... in Stockholm on 29 January 2008. The prizewinner, who is ... field, is invited to Karolinska Institutet in Stockholm for two ...
Cached Medicine News:Health News:Health Dialog and Independence Blue Cross Extend Relationship, Expand Services 2Health News:Health Dialog and Independence Blue Cross Extend Relationship, Expand Services 3Health News:Global Initiative To Protect Children From Secondhand Smoke 2Health News:Global Initiative To Protect Children From Secondhand Smoke 3Health News:Major Community Health Organization Lowers TCO with Ericom's Alternative to Citrix 2Health News:Major Community Health Organization Lowers TCO with Ericom's Alternative to Citrix 3Health News:CPF Appoints Mishka Michon Chief Executive Officer 2Health News:AMERIGROUP Names Linda Whitley-Taylor as Executive Vice President, Associate Services 2Health News:AMERIGROUP Names Linda Whitley-Taylor as Executive Vice President, Associate Services 3
(Date:11/24/2014)...  Marta Rendon, MD, founder of the Rendon Center for ... FL and international key opinion leader in dermatology, was one of ... States to attend the international Aesthetic Experts Summit ... Here, at this gathering of over 600 physicians from 57 ... surgery experts from Asia and ...
(Date:11/24/2014)...  GlySens Incorporated announced today that it has been ... National Institute of Diabetes and Digestive and Kidney Diseases ... (NIH).  The grant is intended to support human clinical ... implantable glucose monitoring system.  Final preparations for launch of ... begin before the end of 2014. "We ...
(Date:11/23/2014)... Calif. , Nov. 23, 2014 Anthera ... that Paul F. Truex , President and Chief ... 2014 Annual Piper Jaffray Healthcare Conference. ... , at the Palace Hotel in New ... Pharmaceuticals Anthera Pharmaceuticals is a biopharmaceutical company ...
Breaking Medicine Technology:Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3GlySens Incorporated Awarded $2 Million Grant from the National Institutes of Health 2Anthera Pharmaceuticals to Present at Annual Piper Jaffray Healthcare Conference 2
... Reportlinker.com announces that a new market research ... Prostate Cancer - Italy Drug Forecasts and Treatment Analysis ... Prostate Cancer - Italy Drug Forecasts and Treatment ... "Prostate Cancer - Italy Drug Forecasts and Treatment Analysis ...
... Calif., Dec. 9, 2010 Ambry Genetics, a global ... sciences industries, announced today that it has officially launched ... Genetics has been an early adapter of Illumina sequencing ... Certified Service Provider. (Logo:   http://photos.prnewswire.com/prnh/20090428/LA06744LOGO ...
Cached Medicine Technology:Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 2Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 3Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 4Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 5Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 6Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 7Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 8Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 9Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 10Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 11Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 12Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 13Reportlinker Adds Prostate Cancer - Italy Drug Forecasts and Treatment Analysis to 2020 14Ambry Genetics Launches Illumina HiSeq 2000 Next Generation Sequencing Services 2