Navigation Links
Hormone may hold key to helping elderly men live longer
Date:5/27/2008

Elderly men with higher activity of the hormone IGF-1or insulin-growth factor 1appear to have greater life expectancy and reduced cardiovascular risk, according to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism (JCEM).

IGF-1 is a hormone similar in molecular structure to insulin. It is released from the liver and plays an important role in childhood growth and continues to have anabolic effects in adults.

In this study, researchers evaluated 376 healthy elderly men between the ages of 73 and 94 years. A serum sample was taken from each subject at the beginning of the study and researchers were contacted about the status of the participants over a period of eight years.

Subjects with the lowest IGF-1 function had a significantly higher mortality rate than subjects with the highest IGF-1 bioactivity. These results were especially significant in individuals who have a high risk to die from cardiovascular complications.

These new findings come as a result of a new form of testing for IGF-bioactivity. Researchers in this study used a new method, a bioassay, to measure the function of IGF-1 in the blood. Compared to commonly used methods to measure IGF-1, the IGF-1 bioassay gives more information about the actual function (bioactivity) of circulating IGF-1 in the body.

The bioassay allowed us to more clearly see the association between high circulating IGF-1 bioactivity and extended survival, said Michael Brugts, MD, of the Erasmus Medical Center in Rotterdam, The Netherlands and lead author of the study. Interestingly, we could not find such a relationship when IGF-1 in blood was measured with the more commonly used methods.

Immunoassays, commonly used previously to determine IGF-1 circulation levels, remove certain proteins that interfere with accurate measurements. Recent studies however have found that these proteins are important modulators of IGF-1 bioactivity. The bioassay used in this study does not disregard or remove this protein, thus enabling researchers to have a more accurate understanding of IGF-1 function.

Determination of IGF-1 function using the bioassay opens the possibility to gather new insights about the functions of IGF-1 in the body, said Brugts.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Blood cholesterol levels predict risk of heart disease due to hormone therapy
2. Hormone Therapy Safe, Effective for Women Entering Menopause
3. Patients, Doctors, Pharmacists Praise Bipartisan House Resolution on Compounded Hormones Containing Estriol
4. Hunger Hormone Makes Food Look More Tasty
5. Heart Hormone Elevated in Children Who Wet Bed
6. Pituitary Hormone May Boost Womens Heart Risk
7. Womens biological clock revealed: Hormone may predict age at menopause
8. ENDO 08: Latest news on hormones, steroids, obesity, diabetes and more
9. Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U.S. and Asia; Gender Difference is Smaller in the Rest of the World
10. Growth hormone is used to treat twice as many short boys than girls in the US and Asia
11. Hormone Replacement May Cut Risk for Age-Linked Eye Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... , ... September 21, 2017 , ... 38-Year-Old Plastic Surgeon ... Center in Naples, Florida is pleased to announce that Plastic Surgeon Kiranjeet Gill has ... 40 Under 40 is an annual award that was started in 2003 to ...
(Date:9/21/2017)... ... September 21, 2017 , ... Hair restoration ... member survey conducted by the International Society of Hair Restoration Surgery ... 2016 rose 60 percent, with 635,189 procedures performed in 2016. , "Like ...
(Date:9/21/2017)... ... September 21, 2017 , ... The New England Center for ... today the election of Yie-Hsin Hung to the Board of Directors. , “The ... of Directors. Ms. Hung is an invaluable addition to our team,” said Vincent Strully, ...
(Date:9/21/2017)... ... September 21, 2017 , ... Sagora ... acquisition of Isle at Kingwood Assisted Living and Memory Care located at 24025 ... community with 55 assisted living apartments, 43 memory care apartments and 23 extended ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... Coating System for clients that rely on safety and cleanliness. This unique flooring ... , Silver has been used for centuries for its antimicrobial properties. Unlike antibiotics, ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... Sept. 19, 2017   ZirMed Inc ., a recognized ... announced that it has been ranked #1 by its users ... Rankings 2017 User Survey. ZirMed was recognized as the ... hospitals and medical centers over 200 beds and holds one ... technology user survey history. ...
(Date:9/12/2017)... 12, 2017  Consumer reviews on the independent review site ... number one company for hearing aids, ranking it higher than ... ... by Consumers For Hearing Aids ... is an online store that provides high performance, state-of-the-art, German-engineered hearing ...
(Date:9/7/2017)... , Sept. 7, 2017  Eli Lilly and ... actions to streamline operations to more efficiently focus ... its cost structure. Global workforce reductions, including those ... expected to impact approximately 3,500 positions. ... expects annualized savings of approximately $500 million that ...
Breaking Medicine Technology: