Navigation Links
Hormone may be new drug target for preventing lymphedema, tumor spread
Date:12/20/2007

CHAPEL HILL A hormone secreted by cells throughout the body and known to play a role in cardiovascular disease and other cell functions is also critical for proper formation of the lymphatic system in mice, according to research from the University of North Carolina at Chapel Hill School of Medicine.

By targeting this hormone, called adrenomedullin, researchers may be able to treat the more than 100 million people worldwide affected by lymphedema, a condition that causes painful swelling in arms and legs.

Our research also may lead to therapies to prevent cancer cells from traveling through these lymphatic vessels to infiltrate other parts of the body, said Kathleen M. Caron, senior study author and assistant professor of cell and molecular physiology and genetics at UNC.

Adrenomedullin is a powerful vascular peptide that can widen existing blood vessels and even promote the growth of new ones. But it also has many more functions, such as helping control metabolism, heart rate, thirst and appetite, stress response, antibacterial activity and nerve signal transmission.

The study, published Dec. 20, 2007, in the Journal of Clinical Investigation, demonstrates that this peptide is necessary for yet another function in our bodies: without it, our lymphatic system an important part of the body's immune system does not form normally. The lymphatic system includes lymph nodes and a network of thin tubes that transport fluid and immune cells that have leached out of tissues back into the circulatory system. These tubes branch, like blood vessels, into all the tissues of the body. Between two and three liters of the almost colorless fluid called lymph go through the lymphatic system in a day.

If this system fails to function properly, excess fluid collects and swells in tissue, causing lymphedema. In rare instances, the condition is inherited through genetic mutations. For two to three million cancer survivors, it c
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drop in breast cancer incidence linked to hormone use, not mammograms
2. Researchers develop long-lasting growth hormone
3. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
4. Less than one-third of women aware of landmark hormone therapy study, Stanford researcher finds
5. Most Women Unaware of Hormone Replacement Study
6. Survival data presented from phase II study of hormone-resistant prostate cancer patients
7. Hormone May Play Key Part in Creating Memories
8. Hormone Therapy for Prostate Cancer Linked to Heart Risks
9. Wyeth to Appeal Nevada Hormone Therapy Trial Verdict
10. New data on hormone therapy must lead to re-evaluation of official guidelines
11. From Hot Flashes to Breast Cancer: ZRT Labs Hormone Testing Catches On As Women Consider Safer, More Natural Options.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... OncLive® today announced ... News & World Report, to provide breaking news and information about the hospital’s ... within OncLive, which provides oncologists resources and information?they need to deliver the best ...
(Date:9/1/2015)... ... September 01, 2015 , ... PetPace, the provider of an ... and activity, today announced its integration with leading veterinary Practice Management Software vendor ... hospital Practice Management Software packages in the US. Practice Management Software helps veterinarians ...
(Date:9/1/2015)... ... 2015 , ... e-Spirit Inc., a leading supplier of content ... Management System with new capabilities and enhancements designed to support the recently announced ... well on their way to achieving digital transformation with less time and less ...
(Date:9/1/2015)... ... 01, 2015 , ... WorkCare, Inc., a national occupational health ... team as an Associate Medical Director. , WorkCare specializes in workforce health ... and abroad. , Dr. Nelson has a diverse background. He trained in ...
(Date:9/1/2015)... Diego, CA (PRWEB) , ... September 01, 2015 , ... ... are just a few of the topics to be discussed at Seedstock’s 4th Annual ... Nov. 3-4, 2015, at UC San Diego. , In addition to keynotes Pierre ...
Breaking Medicine News(10 mins):Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 2Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 3Health News:Petpace-Cornerstone Integration Lowers Overhead, Raises Data Visibility for Veterinary Practices 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 3Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 3Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 2Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 3Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 4Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 5
... National AIDS Control Organization (NACO) of India plans to ... against HIV/AIDS//. The third phase of the National AIDS ... April. , Statistics show that approx. 80 ... for outpatient care and over 50 per cent for ...
... in certain patients following a liver transplant. A new study ... all the risk factors can be detected before a transplant ... risk ,They found the risk factors - a ... (HCV) paired with the use of a particular immunosuppressant- increase ...
... for Disease Control and Prevention (CDC) Atlanta's Division of ... changed its guidelines// and made TB tests mandatory for ... been residing there. ,Tuberculosis can only be ... tested and, if necessary, treated for latent TB infection, ...
... research published in the Jan. 10 issue of the ... chemists// and North Carolina State University toxicologists, finds that ... ,This research was based on the In-Vitro ... amino acids. "Our results confirm that repetitive motion ...
... for schools and nearly 20,000 students stayed home following fears ... to encephalitis two weeks ago. ,Dr. David Gifford, ... the parents' concerns and our concerns, we felt that out ... the next two days. Calling it an outbreak at the ...
... Bush has undergone a hip replacement surgery and is ... went well, the Mayo Clinic in Rochester, Minnesota said ... the father of the current president. His surgery came ... state funeral of former president Gerald Ford, who died ...
Cached Medicine News:Health News:Risk Factors That Cause NODM After A Liver Transplant 2Health News:All Foreign-born Nationals In US To Be Tested For TB 2Health News:A Study Explores the Medical Potentials of Bucky Amino Acids 2
(Date:9/1/2015)... , Sept. 1, 2015   Millstone Medical Outsourcing ... square feet in Olive Branch, MS. ... Branch facility has added the capacity required to ... "This expansion gives us the opportunity to grow ... President of Millstone MS. "Two and a half years ago ...
(Date:9/1/2015)... Belgium , Sept. 1, 2015 ... company focused on developing blood-based diagnostic tests for a broad ... its Chief Executive Officer, Cameron Reynolds , is scheduled ... Conference, which is being held September 9-10, 2015 in ... all day on September 10. Wells Fargo ...
(Date:9/1/2015)... Agena Bioscience TM today announced the establishment ... commercial and financial hub from which many biotech and life ... in mainland China . "The ... sales with almost sixty MassARRAY ® Systems installed to ... allow us to expand our reach and foster a high ...
Breaking Medicine Technology:Millstone Medical Outsourcing Announces Olive Branch Expansion 2VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 2VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 3VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 4Agena Bioscience Opens Office in Shanghai, China 2
... 17 Senesco Technologies, Inc. ("Senesco" or the "Company") ... three months ended September 30, 2009. , Net loss for ... $0.01 per share, compared with a net loss of $1,181,406, or ... 2008. This decrease in net loss was primarily the result ...
... DURHAM, N.C., Nov. 17 Oxygen Biotherapeutics, Inc. (OTC ... begun shipping Dermacyte(TM) Oxygen Concentrate Gel to customers who ... are going out today, cover orders received through early ... our company - actually shipping a product to customers ...
Cached Medicine Technology:Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 2Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 3Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 4Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 5Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 6Senesco Technologies Reports First Quarter Fiscal 2010 Financial Results 7Oxygen Biotherapeutics, Inc. Begins Shipping Cosmetic Product to Customers 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: