Navigation Links
Hormone in birth control shot linked to memory loss
Date:11/1/2011

TEMPE, Ariz. The birth control shot Depo Provera offers a convenient alternative for women who don't want to remember to take a daily pill. Ironically, research from Arizona State University has shown the shot actually may impair a person's memory.

The ASU study connects medroxyprogesterone acetate (MPA), the hormone active in Depo Provera and many widely used menopausal hormone therapies, to impaired memory in rodents. The study is currently in press in the journal Psychopharmacology. An early on line version of the article is available at http://www.springerlink.com/content/53357212117581w6/.

The study was led by Blair Braden, an ASU psychology doctoral student, and Heather Bimonte-Nelson, an ASU associate professor of psychology and director of the Bimonte-Nelson Memory and Aging Lab. The work was done in collaboration with Laszlo Prokai from the University of North Texas Health Sciences Center, Fort Worth, Tex., and Alain Simard from Barrow Neurological Institute, Phoenix.

The Bimonte-Nelson lab first linked MPA to memory loss in rats while studying it as a component of hormone therapy for menopause. This earlier study showed that MPA impaired memory in menopausal-aged rats, and results were published in the November 2010 issue of Neurobiology of Learning and Memory. The current study specifically looks at the drug in relation to the birth control shot.

Bimonte-Nelson said she and Braden began asking questions about the effects of the drug because Braden was concerned about friends taking MPA as a contraceptive.

"This is an important question, because what we are going to have in our future are women who are menopausal that also have a history of taking MPA as birth control when they were younger," said Bimonte-Nelson.

The U.S. Food and Drug Administration originally approved Depo Provera for use in October 1992. It requires an injection every 12 weeks. Its 99 percent effectiveness and the infrequency of doses make the shot an attractive alternative for women seeking to avoid pregnancy.

While other studies have examined Depo Provera's effects on bone density, Bimonte-Nelson's lab is the first to explore its effects on cognition. The researchers note that other forms of hormonal contraception, such as the pill, do not use MPA.

The study lasted approximately one year, using three groups of rats (which received doses at varying ages), plus a control group that did not receive the hormone. To test their memory, rats were placed in water-based mazes to swim and seek out hidden platforms in the water.

"What we found was pretty shocking animals that had been given the drug at any point in their life were memory impaired at middle age compared to animals that never had the drug," said Braden. "We also confirmed that in the subjects that only received the drug when young, the hormone was no longer circulating during memory testing when older, showing it had cleared from the system yet still had effects on brain function."

The researchers also measured a marker of the gamma-aminobutyric acid (GABA) neurotransmitter system in the hippocampus of the rats' brains to determine MPA's physiological effects.

"What GABA does is slow the brain down," Braden said. "So if there is too much of it, it can make it more difficult to produce memories. But then if there's too little of it and there's too much excitation, same thing it makes you not able to produce memories correctly."

The group plans to follow the animal studies with human trials, and the work is leading to results that could have profound implications for women of all ages.

"This research shows that even after this hormone is no longer on board, months and months later, resulting effects are impacting the brain and its function," Bimonte-Nelson said. "This work is an important step forward in our understanding of the potentially long-lasting effects of clinically used hormones on brain function. However, more research is needed to determine whether these effects also occur in women that take this hormone as birth control or part of hormone therapy."


'/>"/>

Contact: Skip Derra
skip.derra@asu.edu
480-965-4823
Arizona State University
Source:Eurekalert

Related medicine news :

1. Obese people regain weight after dieting due to hormones
2. Hunger Hormones May Drive Post-Dieting Weight Gain
3. Research involving thyroid hormone lays foundation for more targeted drug development
4. Breast Cancer Risk May Rise With High Hormone Levels
5. Elevated hormone levels add up to increased breast cancer risk
6. Breast tenderness in women getting combo hormone therapy associated with increase in breast density
7. Shift Workers Show Rise in Stress Hormone
8. Is Female Hormone Disorder Tied to Familial Heart Risk?
9. Stress hormones may increase cardiovascular risks for shift workers
10. New bone-targeting drug delays onset of metastases in hormone-resistant prostate cancer patients
11. Pituitary hormone TSH found to directly influence bone growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
Breaking Medicine Technology: