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Hormone improves long-term recovery from stroke
Date:5/16/2011

Scientists at the Sahlgrenska Academy have discovered an explanation of how stroke patients can achieve better recovery. A hormone that is associated with the growth hormone system has proved to benefit recovery during the later phases of rehabilitation after a stroke.

Insulin-like growth factor I, IGF-I, is a hormone that is found in the blood and contributes to, among other things, growth and bone mass. The levels of this hormone are higher in people who exercise regularly and those with good health. Scientists at the Sahlgrenska Academy have shown for the first time that high levels of this hormone are associated with better long-term recovery after a stroke. The study has been presented in an article in the Journal of Clinical Endocrinology and Metabolism.

"This study is interesting for two reasons. The first is that we show that a hormone is associated with improved long-term recovery, and thus there is still the prospect of improvement even after three months after the stroke. The second is that levels of this hormone are known to be elevated in those who exercise often", says Associate Professor David berg at the Sahlgrenska Academy, who has led the study in collaboration with Professor Jrgen Isgaard.

"It is, however, important to add that the levels of IGF-I are controlled also by other factors such as other growth hormones, heredity and nutrition", emphasises David berg.

The study is based on 407 patients who are participating in the SAHLSIS study at the Sahlgrenska Academy, in which people aged 18-70 years who are affected by stroke are followed up for two years after the event. SAHLSIS is an acronym for "The Sahlgrenska Academy Study on Ischemic Stroke".

Scientists have measured the levels of IFG-I in these 407 patients and seen that increased levels are associated with better recovery, when the degree of recovery is determined between 3 and 24 months after the stroke. Previous research (Bondanelli et al) has also shown a
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Contact: David berg
david.aberg@medic.gu.se
46-031-342-8422
University of Gothenburg
Source:Eurekalert

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