Navigation Links
Hormone Therapy Not Best for Older Prostate Cancer Patients
Date:9/23/2008

Study found giving it before radiation raised death risk 20% in this group

TUESDAY, Sept. 23 (HealthDay News) -- Older men with early-stage prostate cancer who are given hormone therapy before radiation seed implant therapy face a 20 percent greater risk of dying than those who get radiation treatment alone, new research suggests.

Focusing on men over the age of 70, the study summed up the risks of death from any cause linked to androgen-deprivation therapy. Such treatment is sometimes given before radiation treatment to lower male hormone levels, shrink the prostate, and retard cancer growth. Brachytherapy itself involves the insertion of small radioactive seeds into the prostate to destroy cancer cells.

"We know that hormone therapy has a lot of side effects," noted study author Dr. Amy M. Dosoretz, a radiation oncology resident with the Harvard Radiation Oncology Program in Boston. "Depression, fatigue and anemia, among others. Yet it can be worth it, because it has a significant benefit for many patients. But for some patients, the risks may outweigh the benefits. And here, we found that in this particular group of patients -- early-stage prostate cancer patients over 70 -- there was an increased risk for mortality."

Dosoretz and her colleagues were expected to present their findings Tuesday at the American Society for Therapeutic Radiology and Oncology annual meeting, in Boston.

The team's risk assessment is based on a mortality analysis involving more than 1,700 early-stage, localized prostate cancer patients. The men were between the ages of 70 and 91, and received either hormone and brachytherapy treatments or brachytherapy alone between 1991 and 2005.

For those who received hormone therapy, treatment lasted three and a half months on average.

The authors found that undergoing such hormonal intervention was associated with an increased risk of dying from all causes. Being older and having a more aggressive form of prostate cancer was similarly associated with an increased risk of dying from all causes.

"But we still don't know exactly why there's an increased risk for mortality for these patients," Dosoretz cautioned. "So, we need to look into this important issue further, with randomized trials that take in all the bias. Meanwhile, when deciding about hormone therapy treatment, it's important -- especially among elderly men who have early-stage prostate cancer -- to really weigh the benefits and risks."

Dr. Charles J. Ryan, a urologic cancer specialist and an assistant clinical professor of medicine in the division of hematology/oncology at the University of California, San Francisco, agreed.

"We have a pretty good sense that hormone therapy can increase the relative risk for cardiac risk, diabetes and some of the major problems that are likely to kill patients with prostate cancer," Ryan noted. "However, here, the researchers do not address prostate-cancer specific mortality but rather all-cause mortality. And it does a disservice to what hormone therapy can do well to ignore the fact that there have been several studies going back years that show that hormone therapy in addition to radiation improves survival for high-risk patients."

"So, basically, the decision with what to do with hormone therapy needs to be taken in the context of risk," Ryan said.

More information

For additional details on early-stage prostate cancer treatment, visit the National Cancer Institute.



SOURCES: Amy M. Dosoretz, M.D., radiation oncology resident, Harvard Radiation Oncology Program, Boston; Charles J. Ryan, M.D., assistant clinical professor, medicine, division of hematology/oncology, University of California, San Francisco; Sept. 23, 2008, presentation, American Society for Therapeutic Radiology and Oncology meeting, Boston


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Johns Hopkins researchers suppress hunger hormone
2. Acupuncture may hold promise for women with hormone disorder
3. UCLA and biotech company develop first blood test to measure key hormone that regulates iron
4. Monitoring Hormone May Improve Kidney Failure Outcomes
5. Thyroid Hormone May Boost Womens Alzheimers Risk
6. A hormone that enhances ones memory of happy faces
7. Menopause: Hot Flashes Can Be Reduced 90% without Hormones
8. Suckling Infant Triggers Trust Hormone in Moms
9. Hormone Replacement May Raise Womens Gallbladder Risk
10. Hormone Therapy Shows Little Benefit Against Prostate Cancer
11. Breakthrough "Neuro Nutrition" Targets the Brain and Vagus Nerve To Boost the Body's Immune, Hormone and Neurological Systems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hormone Therapy Not Best for Older Prostate Cancer Patients
(Date:4/28/2017)... ... April 28, 2017 , ... Datta Endoscopic ... has joined the revolutionary endoscopic practice under Dr. Datta. Patel is a Board ... Medicine. The patented, revolutionary eDiscSculpt Technique created and used by Datta Endoscopic is ...
(Date:4/28/2017)... ... 2017 , ... People are starting to accept that hearing aids can be ... the stigma it had when great-grandpa wore his hearing aids years ago,” said Dr. ... North American Speaker Series (NASS) segment. “He probably wore an iPod-size hearing ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... assisting the Brooke Grove Foundation implement a Microsoft Dynamics GP solution that integrates ... leading ERP expert that specializes in long-term care, Brooke Grove now has the ...
(Date:4/28/2017)... ... April 28, 2017 , ... Christie Medical Holdings, Inc. , with ... B. Braun Medical Inc. , a leader in infusion therapy and pain management. ... many as 90 percent of hospital patients receiving a peripheral IV catheter as part ...
(Date:4/27/2017)... ... April 27, 2017 , ... The ... the 2017 Public Leadership in Neurology Award (PLINA). The couple joins a prestigious ... Bruschi, Vice President Walter Mondale, actor Michael J. Fox and former U.S. Attorney ...
Breaking Medicine News(10 mins):
(Date:4/25/2017)... 2017 Endo International plc (NASDAQ: ENDP ) ... of its senior management team will host a conference call and ... The dial-in number to access the call is ... the passcode is 6086379. Please dial in 10 minutes prior to ... replay of the call will be available from May 9, 2017 ...
(Date:4/20/2017)... , April 20, 2017  Cogentix Medical, Inc. ... on providing the Urology, Uro/Gyn and Gynecology markets ... Ash Keswani has joined the Company as Senior ... newly created position, Mr. Keswani will report directly ... "Our organization is delighted that Ash ...
(Date:4/20/2017)... 2017  RXi Pharmaceuticals Corporation (NASDAQ: RXII), a ... significant unmet medical needs, today announced that it ... product development program, based on its proprietary self-delivering ... Dermatology (SID) 76 th Annual Meeting.  The ... sciences relevant to skin health and disease through ...
Breaking Medicine Technology: