Navigation Links
Hormone Raises Desire for Fattening Foods
Date:6/22/2010

Study found ghrelin made people crave high-calorie food more

TUESDAY, June 22 (HealthDay News) -- You're dieting, and you know you should stay away from high-calorie snacks. Yet, your eyes keep straying toward that box of chocolates, and you wish there was a pill to restrain your impulse to inhale them.

Such a pill might one day be a real possibility, according to findings presented Tuesday at the Endocrine Society's annual meeting in San Diego. It would block the activity of ghrelin, the "hunger hormone" that stimulates the appetite centers of the brain.

The study, reported by Dr. Tony Goldstone, a consultant endocrinologist at the British Medical Research Council Clinical Sciences Center at Imperial College London, showed that ghrelin does raise the desire for high-calorie foods in humans.

"It's been known from animal and human work that ghrelin makes people hungrier," Goldstone said. "There has been a suspicion from animal work that it can also stimulate the rewards pathways of the brain and may be involved in the response to more rewarding foods, but we didn't have evidence of that in people."

The study that provided such evidence had 18 healthy adults look at pictures of different foods on three mornings, once after skipping breakfast and twice about 90 minutes after having breakfast. On one of the breakfast-eating mornings, all the participants got injections -- some of salt water, some of ghrelin. Then they looked at pictures of high-calorie foods such as chocolate, cake and pizza, and low-calorie foods such as salads and vegetables.

The participants used a keyboard to rate the appeal of those pictures. Low-calorie foods were rated about the same, no matter what was in the injections. But the high-calorie foods, especially sweets, rated higher in those who got ghrelin.

"It seems to alter the desire for high-calorie foods more than low-calorie foods," Goldstone said of ghrelin.

That effect was especially pronounced when the participants fasted overnight before the study was done. "We know that when you fast, you tend to crave high-calorie foods more," Goldstone said. "We mimicked that effect."

So a pill that blocked ghrelin's activity could be useful for dieters, and several drug companies already are working to develop one, he said. It wouldn't be something you could pop when a tempting dish appeared, because the blocking effect would take some time to happen, but it could be part of an overall weight-loss regimen, Goldstone said.

"If developed, it might have the particular effect of blocking the desire for high-calorie foods," he said.

The study results come as no surprise, said Alain Dagher, an associate professor of neurology at McGill University in Montreal, who has been studying ghrelin.

In his research, MRI scans of animals found that "ghrelin increases the brain response to food," Dagher said. "So, it's not surprising that a single injection in humans supports a shift to high-calorie foods in general."

Dagher is continuing his studies. "We've been trying to get more specific about exactly how ghrelin acts on the brain, which brain regions it affects and how those effects translate to eating," he said.

Ghrelin might not play a role in causing obesity, but it might act to keep people obese by reducing their ability to lose weight, Dagher said.

More information

To learn what ghrelin is and does, visit the University of Edinburgh.



SOURCES: Tony Goldstone, M.D., Ph.D, consultant endocrinologist, Medical Research Council Clinical Sciences Center, Imperial College London; Alain Dagher, Ph.D, associate professor, neurology, McGill University, Montreal; June 22, 2010, presentation, Endocrine Society annual meeting, San Diego


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experts Issue Warning on Prostate Hormone Therapy
2. Stress Hormone Could Be Key to Alcoholism
3. Treating Low Growth Hormone in Childhood May Thwart Later Ills
4. More blood vessels in hormone-resistant prostate tumors
5. Fat Hormone May Protect Against Alzheimers
6. New human reproductive hormone could lead to novel contraceptives
7. Prostate Hormone Therapy May Up Heart Risks
8. Pioneering Hormone Therapist to Host Free Health Seminar
9. Hormone May Prevent Aggressive Breast Cancer
10. Bonding Hormone Might Help Some With Autism
11. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hormone Raises Desire for Fattening Foods
(Date:5/24/2016)... ... May 24, 2016 , ... Educational opportunities, ... housing, with more advantaged communities providing richer opportunities. Recognizing the key role of ... school improvement policies; (b) school choice policies; (c) school desegregation policies; (d) wealth-focused ...
(Date:5/24/2016)... ... ... New Brunswick, New Jersey: This year marks Children’s Specialized Hospital ’s 125th anniversary ... anniversary, the hospital has themed the milestone “Hats Off” and kicked off the yearlong ... Saturday, May 21, at Johnson Park in Piscataway, New Jersey. , “Hats ...
(Date:5/24/2016)... ... (PRWEB) May 24, 2016 -- Grow Healthy ... Advisory Board. Joining the Grow Healthy Advisory Board team are ... embody the mission of our organization and bring talent, expertise and ... as we continue to expand our footprint as the leader in ...
(Date:5/24/2016)... ... May 24, 2016 , ... Boyd Industries, a leading supplier of ... groundbreaking new product for pediatric dentistry , at AAPD 2016, the annual conference ... May 26-29. The Concealed Delivery Unit keeps dental hand pieces and other anxiety-provoking pieces ...
(Date:5/24/2016)... ... May 24, 2016 , ... Eggsurance, the first independent, non-clinic ... its community and education hub for women considering fertility preservation, as well as ... safe and welcoming place for women to find cycle buddies, get clinic recommendations ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 The innovator of ... , s first dual therapy stent, introduces catheters ... OrbusNeich, a global company specializing in the provision ... include products to treat peripheral artery disease. The JADE™ ... devices for lower limb and arteriovenous (AV) fistula intervention. ...
(Date:5/24/2016)... , May 24, 2016 Dutch surgeons ... best practices around the world and treat patients on a global ... Africa , Asia and the US ... with instant messaging and networking in a totally secure environment. ... in a war zone working together with a surgeon at Harvard ...
(Date:5/23/2016)... FLINT, Mich. , May 23, 2016 Diplomat ... the third annual Fellowship and Internship programs. The hands-on ... 12. The full-time, paid Fellowship ... Flint, Michigan . Fellows and interns are ... downtown Flint at the Riverfront ...
Breaking Medicine Technology: