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Hormone Normalization Shows Encouraging Effects In Documented Clinically Deficient Men/Women
Date:10/15/2008

Klimas's behalf to look at probably one of the most comprehensive practices in age management medicine in the country over the last seven to nine years to formulate outcome measures retrospectively," said Ginzburg, who was the study's principal investigator.

The retrospective study surveyed 91 men and 97 women, ages 25 to 82, who were treated over a three-year period for clinically documented hormone deficiencies, testosterone and/or growth hormone. They were compared with controls to evaluate the treatment regimen's effect on body mass and whether there are differences among these groups.

Researchers established an organized database to determine outcome measures on bone density, Beck depression and lean body mass as well as review markers, such as PSAs (prostate-specific antigen to help mark prostate cell activity).

In phase one, positive results showed a significant improvement in the effects of Beck depression tests and quality-of-life tests with the use of hormone normalization along with improvement in lean body mass, decreased percentage of adipose tissue and increased bone density in men and women across a wide age range.

Cenegenics signed a two-year agreement with Ginzburg and Klimas for completing phases two and three.

Phase two will look at overall safety issues with regards to tumor formation as compared to a normal population.

"Phase three is going to be a more extensive analysis," Ginzburg said. "We really need larger numbers to make it significant in respect to the findings."

Dr. Enrique Ginzburg is a professor of surgery at the University of Miami - Miller School of Medicine's Divisions of Trauma and Surgical Critical Care. He is also the medical director at the International Health Center and co-director at the Neuroscience Intensive Care.

Dr. Nancy Klimas is a recognized leader and a champion of research in chronic fatigue syndrome. She is a profess
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