Navigation Links
Hormone May Prevent Aggressive Breast Cancer
Date:2/11/2010

Discovery of prolactin's role could improve diagnosis and treatment, researchers say,,,,

THURSDAY, Feb. 11 (HealthDay News) -- A hormone responsible for milk production blocks a gene that makes breast cancer more aggressive, according to new research by U.S. scientists.

The discovery, they say, could lead to better diagnostic tests for breast cancer and new treatments for the disease.

The researchers found that the hormone prolactin, which normally stimulates breast development and milk production, reduces levels of an oncogene called BCL6. Previous studies had shown that BCL6 plays a role in poorly differentiated breast cancer. Women with this type of breast cancer have a poor prognosis.

To a large extent, prolactin's role in breast cancer is carried out by a protein pathway called Stat5, the researchers explained, and inactivation of Stat5 is related to poorly differentiated breast cancer.

"We found that prolactin will block expression of the BCL6 protein and showed that Stat5a, but not the very similar Stat5b variant, is involved in this process as a mediator of prolactin," Dr. Hallgeir Rui, a professor of cancer biology and medical oncology at Jefferson Medical College at Thomas Jefferson University, said in a university news release.

"We think that prolactin plays an important role in preventing aggressive breast cancers and that there is a connection between the loss of Stat5 and the increase of BCL6 in making breast cancer more aggressive," Rui said.

His research team found that the connection was consistent in several different breast cancer cell lines grown in the laboratory as well as those in mice and in human breast cancer samples.

The study was published online Feb. 2 in Cancer Research.

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: Thomas Jefferson University, news release, Feb. 3, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pioneering Hormone Therapist to Host Free Health Seminar
2. Experts Issue Warning on Prostate Hormone Therapy
3. Stress Hormone Could Be Key to Alcoholism
4. Treating Low Growth Hormone in Childhood May Thwart Later Ills
5. New human reproductive hormone could lead to novel contraceptives
6. Fat Hormone May Protect Against Alzheimers
7. More blood vessels in hormone-resistant prostate tumors
8. Prostate Hormone Therapy May Up Heart Risks
9. Protein from pregnancy hormone may prevent breast cancer
10. Workshop on economics, neuroscience and hormones
11. Love Hormone May Trigger Jealousy, Too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... Eating ... a significant number of women and men with eating disorders report a history ... best predicts the development of an eating disorder. , At the 2016 ...
(Date:2/8/2016)... ... 2016 , ... GrassrootsHealth published data from its D*action public ... in the GrassrootsHealth cohort with substantially higher vitamin D levels than a cohort ... states Carole Baggerly, Director of GrassrootsHealth, “the safety and benefits of vitamin ...
(Date:2/8/2016)... Las Vegas, Nevada (PRWEB) , ... February 08, ... ... Co-Founder at RowdMap, Inc., will be speaking on how healthcare companies can use ... project costs, manage the health of a population and intervene and capture the ...
(Date:2/8/2016)... ... , ... According to research by the National Association of ... be certified or obtain continuing education. To increase patient awareness of the lack ... campaign to inform dentists and patients about the possible lack of skills and ...
(Date:2/7/2016)... (PRWEB) , ... February 07, 2016 , ... ... MyDecision™ program. MyDecision™ empowers employers and organizations with the tools and information to ... combines three elements to cut the cost of providing employee healthcare benefits by ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Ill. , Feb. 8, 2016  Astellas Pharma Inc. ... announced the promotion of James Robinson as president, ... company,s operations in North and South America ... Astellas Pharma US, representing the commercial organization in ... in 2013. Masao Yoshida , who is ...
(Date:2/8/2016)... Feb. 8, 2016  CTI BioPharma Corp. (CTI BioPharma) ... written communication from the U.S. Food and Drug Administration ... placed a partial clinical hold on the clinical studies ... application for pacritinib. This clinical hold impacts part of ... and will also affect planned clinical trials. ...
(Date:2/5/2016)... , Feb. 5, 2016  Redwood Scientific Technologies, ... new product designed to help women balance their hormones. ... delivery technology. Jason Cardiff , President ... be able to help the millions of women across ... the effects of imbalanced hormones. Our research and development ...
Breaking Medicine Technology: