Navigation Links
Hormone May Prevent Aggressive Breast Cancer
Date:2/11/2010

Discovery of prolactin's role could improve diagnosis and treatment, researchers say,,,,

THURSDAY, Feb. 11 (HealthDay News) -- A hormone responsible for milk production blocks a gene that makes breast cancer more aggressive, according to new research by U.S. scientists.

The discovery, they say, could lead to better diagnostic tests for breast cancer and new treatments for the disease.

The researchers found that the hormone prolactin, which normally stimulates breast development and milk production, reduces levels of an oncogene called BCL6. Previous studies had shown that BCL6 plays a role in poorly differentiated breast cancer. Women with this type of breast cancer have a poor prognosis.

To a large extent, prolactin's role in breast cancer is carried out by a protein pathway called Stat5, the researchers explained, and inactivation of Stat5 is related to poorly differentiated breast cancer.

"We found that prolactin will block expression of the BCL6 protein and showed that Stat5a, but not the very similar Stat5b variant, is involved in this process as a mediator of prolactin," Dr. Hallgeir Rui, a professor of cancer biology and medical oncology at Jefferson Medical College at Thomas Jefferson University, said in a university news release.

"We think that prolactin plays an important role in preventing aggressive breast cancers and that there is a connection between the loss of Stat5 and the increase of BCL6 in making breast cancer more aggressive," Rui said.

His research team found that the connection was consistent in several different breast cancer cell lines grown in the laboratory as well as those in mice and in human breast cancer samples.

The study was published online Feb. 2 in Cancer Research.

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: Thomas Jefferson University, news release, Feb. 3, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pioneering Hormone Therapist to Host Free Health Seminar
2. Experts Issue Warning on Prostate Hormone Therapy
3. Stress Hormone Could Be Key to Alcoholism
4. Treating Low Growth Hormone in Childhood May Thwart Later Ills
5. New human reproductive hormone could lead to novel contraceptives
6. Fat Hormone May Protect Against Alzheimers
7. More blood vessels in hormone-resistant prostate tumors
8. Prostate Hormone Therapy May Up Heart Risks
9. Protein from pregnancy hormone may prevent breast cancer
10. Workshop on economics, neuroscience and hormones
11. Love Hormone May Trigger Jealousy, Too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the placement of ... President of North American Capital Sales at HTG Molecular . , ... the commercialization of the HTG EdgeSeq system and associated reagents in North America. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 , , , WHEN: ... 2016 , , , , LOCATION: , , , Online, ... , , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global ... Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager ... pharmaceutical industry is witnessing an exceptional era. Several new demand spaces, ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
(Date:6/23/2016)... The Biotechnology industry might still ... great opportunities to investors. Stock-Callers.com assesses the recent performances ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... your complimentary trade alerts at: http://stock-callers.com/registration ...
Breaking Medicine Technology: