Navigation Links
Hormone May Prevent Aggressive Breast Cancer
Date:2/11/2010

Discovery of prolactin's role could improve diagnosis and treatment, researchers say,,,,

THURSDAY, Feb. 11 (HealthDay News) -- A hormone responsible for milk production blocks a gene that makes breast cancer more aggressive, according to new research by U.S. scientists.

The discovery, they say, could lead to better diagnostic tests for breast cancer and new treatments for the disease.

The researchers found that the hormone prolactin, which normally stimulates breast development and milk production, reduces levels of an oncogene called BCL6. Previous studies had shown that BCL6 plays a role in poorly differentiated breast cancer. Women with this type of breast cancer have a poor prognosis.

To a large extent, prolactin's role in breast cancer is carried out by a protein pathway called Stat5, the researchers explained, and inactivation of Stat5 is related to poorly differentiated breast cancer.

"We found that prolactin will block expression of the BCL6 protein and showed that Stat5a, but not the very similar Stat5b variant, is involved in this process as a mediator of prolactin," Dr. Hallgeir Rui, a professor of cancer biology and medical oncology at Jefferson Medical College at Thomas Jefferson University, said in a university news release.

"We think that prolactin plays an important role in preventing aggressive breast cancers and that there is a connection between the loss of Stat5 and the increase of BCL6 in making breast cancer more aggressive," Rui said.

His research team found that the connection was consistent in several different breast cancer cell lines grown in the laboratory as well as those in mice and in human breast cancer samples.

The study was published online Feb. 2 in Cancer Research.

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: Thomas Jefferson University, news release, Feb. 3, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pioneering Hormone Therapist to Host Free Health Seminar
2. Experts Issue Warning on Prostate Hormone Therapy
3. Stress Hormone Could Be Key to Alcoholism
4. Treating Low Growth Hormone in Childhood May Thwart Later Ills
5. New human reproductive hormone could lead to novel contraceptives
6. Fat Hormone May Protect Against Alzheimers
7. More blood vessels in hormone-resistant prostate tumors
8. Prostate Hormone Therapy May Up Heart Risks
9. Protein from pregnancy hormone may prevent breast cancer
10. Workshop on economics, neuroscience and hormones
11. Love Hormone May Trigger Jealousy, Too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... videos a whole new perspective by using the title layers in ProSlice Levels ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
Breaking Medicine Technology: