Navigation Links
Hormone May Prevent Aggressive Breast Cancer
Date:2/11/2010

Discovery of prolactin's role could improve diagnosis and treatment, researchers say,,,,

THURSDAY, Feb. 11 (HealthDay News) -- A hormone responsible for milk production blocks a gene that makes breast cancer more aggressive, according to new research by U.S. scientists.

The discovery, they say, could lead to better diagnostic tests for breast cancer and new treatments for the disease.

The researchers found that the hormone prolactin, which normally stimulates breast development and milk production, reduces levels of an oncogene called BCL6. Previous studies had shown that BCL6 plays a role in poorly differentiated breast cancer. Women with this type of breast cancer have a poor prognosis.

To a large extent, prolactin's role in breast cancer is carried out by a protein pathway called Stat5, the researchers explained, and inactivation of Stat5 is related to poorly differentiated breast cancer.

"We found that prolactin will block expression of the BCL6 protein and showed that Stat5a, but not the very similar Stat5b variant, is involved in this process as a mediator of prolactin," Dr. Hallgeir Rui, a professor of cancer biology and medical oncology at Jefferson Medical College at Thomas Jefferson University, said in a university news release.

"We think that prolactin plays an important role in preventing aggressive breast cancers and that there is a connection between the loss of Stat5 and the increase of BCL6 in making breast cancer more aggressive," Rui said.

His research team found that the connection was consistent in several different breast cancer cell lines grown in the laboratory as well as those in mice and in human breast cancer samples.

The study was published online Feb. 2 in Cancer Research.

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: Thomas Jefferson University, news release, Feb. 3, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pioneering Hormone Therapist to Host Free Health Seminar
2. Experts Issue Warning on Prostate Hormone Therapy
3. Stress Hormone Could Be Key to Alcoholism
4. Treating Low Growth Hormone in Childhood May Thwart Later Ills
5. New human reproductive hormone could lead to novel contraceptives
6. Fat Hormone May Protect Against Alzheimers
7. More blood vessels in hormone-resistant prostate tumors
8. Prostate Hormone Therapy May Up Heart Risks
9. Protein from pregnancy hormone may prevent breast cancer
10. Workshop on economics, neuroscience and hormones
11. Love Hormone May Trigger Jealousy, Too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Individuals who have been ... to surgery, treatment, therapy and management. Regular exercise in proper environments has been ... despite their diseases. On February 23, 2017, 1:00-2:00 p.m. E.S.T., a dynamic ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... coverage in veterinary medicine, will be launching its first bi-monthly issue of 2017 ... medicine, business and practice management, and One Health. , In making the ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... the predictive analytic firm Predixion’s Healthcare IT practice. Predixion, which raised $42M+ to ... backed by giants including Accenture, GE Ventures, and Software AG , will ...
(Date:2/21/2017)... , ... February 21, 2017 , ... A February 6 ... gastric balloons for weight loss. It found that the treatments have led to significant ... patients, when compared to unassisted efforts. It also noted very few problematic results relating ...
(Date:2/20/2017)... Ill. (PRWEB) , ... February 20, 2017 , ... ... to reduce the rate at which women are called back for additional examinations ... journal Radiology . , In 2011, the U.S. Food and Drug Administration ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Research and Markets has announced the addition of ... Report" report to their offering. ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , Latin America ... the period 2015 through 2022. Also, a six-year historic analysis is provided ...
(Date:2/21/2017)... DUBLIN , Feb. 21, 2017 Research and ... and Strategies - 2016" report to their offering. ... The latest research Anthrax Drugs Price Analysis ... global Anthrax market. The research answers the following questions: ... their clinical attributes? How are they positioned in the Global Anthrax market? ...
(Date:2/20/2017)... , Feb. 20, 2017 Provides understanding ... and agreements entered into by the worlds leading ... https://www.reportbuyer.com/product/3605699/ Description The Global Renal Failure ... understanding and access to partnering deals and agreements ... - Trends in partnering deals ...
Breaking Medicine Technology: