Navigation Links
Hormone Lowers Glucose Levels in Mice
Date:11/4/2008

Injections of apelin appear to be similar to insulin, study says

TUESDAY, Nov. 4 (HealthDay News) -- A hormone produced by fat tissues holds promise for people with insulin resistance or type 2 diabetes, a new report suggests.

The hormone, called apelin, significantly lowered blood sugar levels when injected intravenously into normal and obese mice, according to a study published in the November issue of the journal Cell Metabolism. Apelin also appeared to restore glucose tolerance and improve glucose uptake in mice that are obese and insulin resistant.

According to the finding, apelin seems to stimulate muscle and fat tissue so it better absorbs glucose from the bloodstream. It does this by activating a pathway for AMP-activated protein kinase (AMPK), an enzyme that's key to control of skeletal muscle glucose and the metabolism of fatty acids, the researchers said.

"The present study reveals apelin as a new endocrine regulator of AMPK and strengthens the crosstalk between [fat] and skeletal muscle," the researchers wrote. "The involvement of AMPK in apelin-mediated glucose uptake represents an attractive pathway that could conceivably lead to a new drug target for the treatment of metabolic disorders."

Researcher Isabelle Castan-Laurell of the Institut National de la Sante et de la Recherche Medicale and the Universite de Toulouse, noted in a news release issued by the journal's publisher that previous studies have found similarities and parallels between the effects of apelin and insulin.

The effects of long-term apelin treatment in mice will be examined next to see if it can prevent obesity and insulin resistance, the researchers said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.



-- Kevin McKeever



SOURCE: Cell Press, news release, Nov. 4, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Natural Hormone Balance: Gaining Ground in the Fight Against Breast Cancer
2. Large hormone dose may reduce risk of post-traumatic stress disorder
3. New hormone data can predict menopause within a year
4. Hormones May Be to Blame for Womens Cavity Rates
5. Hormone Normalization Shows Encouraging Effects In Documented Clinically Deficient Men/Women
6. Candice Lane MD Launches Hormone Health MD Plus: The First Doctor Bioidentical Hormone Blog
7. Breast Cancer Action Targets Yoplait in Think Before You Pink Campaign; Calls for Yogurt Without Artificial Hormones
8. Age alone should not be used to determine whether to treat prostate cancer with hormones
9. Hormone Therapy Not Best for Older Prostate Cancer Patients
10. Johns Hopkins researchers suppress hunger hormone
11. Acupuncture may hold promise for women with hormone disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/25/2017)... ... September 25, 2017 , ... ... not an option to senior, upper-level executives speaking at a business luncheon today, ... senior, high-level executive is an asset to be fully realized and activated by ...
(Date:9/25/2017)... ... September 25, 2017 , ... Dr. Edward Hebert is celebrating ... imagine doing anything else,” said Dr. Hebert. “I count my blessings daily for the ... with my patients is what I look forward to the most. The relationships I ...
(Date:9/25/2017)... ... September 25, 2017 , ... “Grandpa's Visit”: a ... teach and share with the others. “Grandpa's Visit” is the creation of published author, ... that she is much like the character in her book. She shares, “Mr. Rice ...
(Date:9/25/2017)... CA (PRWEB) , ... September 25, 2017 , ... The ... have awarded REBBL®, maker of organic coconut-milk based super herb drinks, with the new ... , This was the inaugural year for the NEXTY Gold, which is reserved for ...
(Date:9/25/2017)... ... ... Borers kill Ash trees in as little as 1-3 years. The signs of ... Rob Nagy, ISA Certified Arborist at Giroud Tree and Lawn, shows a street in Northeast ... of decline from Emerald Ash Borers, two Ash trees continue to thrive. , ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017  Zimmer Biomet Holdings, ... musculoskeletal healthcare, today announced that it will be participating ... Healthcare Conference at the Grand Hyatt hotel in New ... 2017 at 11:40 a.m. Eastern Time. A ... Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com . ...
(Date:9/6/2017)... WILMINGTON, Del. , Sept. 6, 2017 NeuroRx, ... for Acute Suicidal Ideation and Behavior (ASIB), has been granted ... for its sequential therapy of NRX-100 (ketamine HCl) followed by ... patients in a pivotal trial of this sequential therapy targeting ... bipolar depression. 1 ...
(Date:9/5/2017)... Sept. 5, 2017  Just 18 months after its ... pleased to announce the appointment of three new senior ... , Dominic Jones-Phillips and James Wright ... Tammy Wynne ... market access writers. She has over ten years, experience ...
Breaking Medicine Technology: