Navigation Links
Hormone Lowers Glucose Levels in Mice
Date:11/4/2008

Injections of apelin appear to be similar to insulin, study says

TUESDAY, Nov. 4 (HealthDay News) -- A hormone produced by fat tissues holds promise for people with insulin resistance or type 2 diabetes, a new report suggests.

The hormone, called apelin, significantly lowered blood sugar levels when injected intravenously into normal and obese mice, according to a study published in the November issue of the journal Cell Metabolism. Apelin also appeared to restore glucose tolerance and improve glucose uptake in mice that are obese and insulin resistant.

According to the finding, apelin seems to stimulate muscle and fat tissue so it better absorbs glucose from the bloodstream. It does this by activating a pathway for AMP-activated protein kinase (AMPK), an enzyme that's key to control of skeletal muscle glucose and the metabolism of fatty acids, the researchers said.

"The present study reveals apelin as a new endocrine regulator of AMPK and strengthens the crosstalk between [fat] and skeletal muscle," the researchers wrote. "The involvement of AMPK in apelin-mediated glucose uptake represents an attractive pathway that could conceivably lead to a new drug target for the treatment of metabolic disorders."

Researcher Isabelle Castan-Laurell of the Institut National de la Sante et de la Recherche Medicale and the Universite de Toulouse, noted in a news release issued by the journal's publisher that previous studies have found similarities and parallels between the effects of apelin and insulin.

The effects of long-term apelin treatment in mice will be examined next to see if it can prevent obesity and insulin resistance, the researchers said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.



-- Kevin McKeever



SOURCE: Cell Press, news release, Nov. 4, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Natural Hormone Balance: Gaining Ground in the Fight Against Breast Cancer
2. Large hormone dose may reduce risk of post-traumatic stress disorder
3. New hormone data can predict menopause within a year
4. Hormones May Be to Blame for Womens Cavity Rates
5. Hormone Normalization Shows Encouraging Effects In Documented Clinically Deficient Men/Women
6. Candice Lane MD Launches Hormone Health MD Plus: The First Doctor Bioidentical Hormone Blog
7. Breast Cancer Action Targets Yoplait in Think Before You Pink Campaign; Calls for Yogurt Without Artificial Hormones
8. Age alone should not be used to determine whether to treat prostate cancer with hormones
9. Hormone Therapy Not Best for Older Prostate Cancer Patients
10. Johns Hopkins researchers suppress hunger hormone
11. Acupuncture may hold promise for women with hormone disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
Breaking Medicine Technology: