Navigation Links
Hormone Linked to Death Risk in Those With Early Kidney Disease
Date:6/14/2011

TUESDAY, June 14 (HealthDay News) -- Patients with early-stage chronic kidney disease are more likely to die if they have elevated levels of a certain hormone, a new study says.

Endocrine hormone fibroblast growth factor 23 (FGF-23) regulates phosphorus metabolism. It was known that levels of FGF-23 increase as kidney function declines and that high levels of the hormone are associated with increased risk of death in patients with kidney failure. But little was known about how elevated levels of FGF-23 affect outcomes of patients with early-stage chronic kidney disease.

This study looked at 3,879 patients with early-stage chronic kidney disease. During a median follow-up of 3.5 years, 266 of the patients died and 410 progressed to kidney failure. The researchers found that median FGF-23 levels were higher in these patients than in those who remained "event-free."

Patients with the highest levels of FGF-23 were 4.3 times more likely to die than those with the lowest levels, according to the study in the June 15 issue of the Journal of the American Medical Association.

The researchers said they were surprised to find that high FGF-23 levels were more strongly associated with death than other factors, including cardiovascular disease and chronic kidney disease-specific risk factors such as reduced estimated glomerular filtration rate (GFR, a measure of the kidney's ability to filter out and remove waste products) and proteinuria (excessive protein in the urine).

The reasons for the link between elevated FGF-23 levels and increased risk of death aren't known.

"If the results of the current study are confirmed and experimental studies support the hypothesis of direct toxicity of FGF-23, future research should evaluate whether therapeutic or preventative strategies that lower FGF-23 can improve outcomes," Dr. Tamara Isakova, of the University of Miami Miller School of Medicine, and colleagues said in a news release from the journal.

More information

The American Academy of Family Physicians has more about chronic kidney disease.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, June 14, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pioneering Hormone Therapist to Host Free Health Seminar
2. Hormone May Prevent Aggressive Breast Cancer
3. Bonding Hormone Might Help Some With Autism
4. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
5. Early On, Hormone Therapy May Raise Womens Heart Risks
6. Testicular Cancer Survivors May Have Hormone Deficiency
7. Stress hormone, depression trigger obesity in girls
8. Buy HGH Website Educates Consumers on the Pros and Cons of Human Growth Hormone Supplements
9. Hormone thought to slow aging associated with increased risk of cancer death
10. Hormone Outperforms Insulin in Diabetic Mice
11. High Hormone Level Linked to Cancer Death in Older Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is ... emergency ambulance transport experience for the millions of people who require these medical ... the taxi industry through the use of technology. Now, SmartEMS has put forth ...
(Date:6/26/2016)... ... 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... videos a whole new perspective by using the title layers in ProSlice Levels ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: