Navigation Links
Hormone Linked to Absence of Periods in Women With Low Body Fat
Date:4/8/2011

FRIDAY, April 8 (HealthDay News) -- A lack of leptin contributes to the absence of menstrual periods in women with extremely low levels of body fat, but treatment with a synthetic form of the hormone may restore both the menstrual cycle and fertility, a new study indicates.

Extremely low levels of body fat can occur in women who are unusually active, such as runners and dancers, and in those with eating disorders. These women are prone to the absence of periods (known to doctors as hypothalamic amenorrhea, or HA), which can lead to infertility and osteoporosis.

Previous research found that women with HA have chronically low serum leptin levels. This new study, published online in the Proceedings of the National Academy of Sciences, is the first to offer definitive proof that a lack of leptin contributes to HA.

The randomized, double-blind study included 20 women, ages 18 to 35, with HA. Many of them were runners. Over 36 weeks, the women received daily injections of either a synthetic form of leptin called metreleptin or a placebo, without the participants or the researchers being aware who was receiving the real or sham therapy.

Within one month of starting treatment, the women who received the metreleptin showed significantly increased levels of leptin.

"Seven of 10 women began to menstruate and four of the seven were found to be ovulating," senior author Dr. Christos Mantzoros, director of the Human Nutrition Unit at Beth Israel Deaconess Medical Center and a professor of medicine at Harvard Medical School, said in a BIDMC news release.

"Compared with women who received the placebo, the women who received the metreleptin therapy were also found to have an improved hormonal profile and exhibited higher levels of biomarkers indicating new bone formation," he added.

The synthetic leptin used in the study, which was funded in part by the National Institutes of Digestive and Kidney Diseases, was provided by Amylin Pharmaceuticals, Inc.

More information

The U.S. National Institute of Child Health and Human Development has more about amenorrhea.

-- Robert Preidt

SOURCE: Beth Israel Deaconess Medical Center, news release, April 4, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Pioneering Hormone Therapist to Host Free Health Seminar
2. Hormone May Prevent Aggressive Breast Cancer
3. Bonding Hormone Might Help Some With Autism
4. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
5. Early On, Hormone Therapy May Raise Womens Heart Risks
6. Testicular Cancer Survivors May Have Hormone Deficiency
7. Stress hormone, depression trigger obesity in girls
8. Buy HGH Website Educates Consumers on the Pros and Cons of Human Growth Hormone Supplements
9. Hormone thought to slow aging associated with increased risk of cancer death
10. Hormone Outperforms Insulin in Diabetic Mice
11. High Hormone Level Linked to Cancer Death in Older Men
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hormone Linked to Absence of Periods in Women With Low Body Fat 
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
Breaking Medicine Technology: