Navigation Links
Hormone Drug May Help Drinkers Stay Sober
Date:2/27/2009

Study finds 'alcoholic' rats on cabergoline cut consumption, were less prone to relapse

FRIDAY, Feb. 27 (HealthDay News) -- A pill normally prescribed to help with infertility and menstrual disorders may also help treat alcoholism, a new study says.

When injected with cabergoline (Dostinex), rats addicted to alcohol decreased their drinking and addictive behavior while also being less prone to relapsing, a study by researchers at the University of California, San Francisco, found. The findings were published online in Biological Psychiatry.

Use of cabergoline also didn't seem to affect other behavior, such as the rats' intake of water or sugar.

"This is encouraging, because it demonstrates that cabergoline is specific for alcohol but does not affect general reward or pleasure. One of the problems with some existing drugs to treat alcoholism is a side effect that decreases pleasure, making compliance an obstacle to sobriety," associate professor of neurology Dorit Ron, a principal investigator at the university's Ernest Gallo Clinic and Research Center, said in a news release issued by the school.

The pill form of cabergoline has been approved by the U.S. Food and Drug Administration to counter conditions caused by the body producing too much of the hormone prolactin. The medication had been shown to increase the body's production of glial cell line-derived neurotrophic factor protein (GDNF), which the research team had previously found decreased the desire for alcohol in addicted rodents when injected straight into the region of the brain linked to drug-seeking behavior.

In the new experiment, rats were trained to press a lever to obtain alcohol. When given cabergoline injections, the rats were less likely to press the lever -- the higher the dose, the fewer presses of the lever, the researchers found. Also, the team reported that binge-drinking mice drank less alcohol after receiving cabergoline.

The drug also appeared effective at cutting the craving for alcohol and lowering the risk of relapse, a critical issue for recovering alcoholics.

The experiment was further strengthened when cabergoline was given to mice genetically modified to have only a single copy of the GDNF gene, which would mean less of the protein could be produced. The drug had no effect on the drinking habits of these altered mice, the researchers reported.

The study, while noting success with cabergoline in a pilot study on human cocaine addicts, also warned the drug had been linked to heart value issues when given in higher doses as a treatment for Parkinson's disease.

"However," Ron said, "we show that in mice and rats, a low dose of the drug is enough to reduce excessive alcohol consumption, alcohol seeking and relapse. The dose is similar to what is given to humans for the treatment of hyperprolactinemia."

Only three medications have FDA approval for treating alcohol dependence -- disulfiram (Antabuse), naltrexone (Depade, ReVia), and acamprosate (Campral).

The U.S. National Institutes of Health estimates that almost 18 million people in the United States -- approximately one in every 12 adults -- abuses alcohol or is alcohol-dependent.

More information

The U.S. National Institute on Alcohol Abuse and Alcoholism has more about alcoholism.



-- Kevin McKeever



SOURCE: University of California, San Francisco, news release, Feb. 23, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. U of I study shows benefits of hormone found in fat tissue
2. Hormones May Help Shield Women from Parkinsons
3. UCSF Gallo Study Finds Hormone Disorder Drug Could Help Drinkers Stay Sober
4. Hormone linked to high blood pressure and blood vessel disease in African-Americans
5. Findings raise new questions about evolution of hormones in mammals
6. Male Hormone Replacement Therapy Optimism for 2009
7. Female Hormones Deter Salt-Sensitive Hypertension
8. 2 Years of Hormone Use May Be Safe
9. Growth hormone treatment after weight loss surgery prevents loss of muscle mass
10. Study identifies potential safe period for hormone replacement use
11. The Truth About Bio-identical Hormone Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hormone Drug May Help Drinkers Stay Sober
(Date:5/25/2016)... ... May 25, 2016 , ... Afrimesure specializes in providing ... pharmaceutical, to food and HVAC facilities. Their knowledgeable staff also takes care of ... medical applications, Afrimesure offers a variety of MadgeTech systems available for sterilization and ...
(Date:5/25/2016)... ... May 25, 2016 , ... Casa Velas, an adults-only boutique hotel ... stones to complement its new wellness suites . The two 1,350 sq. ft. ... plethora of special services and insuite amenities, from a custom soap selection and in-suite ...
(Date:5/25/2016)... ... ... The University of San Francisco (USF) has named Margaret Wooding Baker dean ... more than 100 full-time faculty and staff, and serve as a member of the ... Baker comes to USF from the University of Washington in Seattle, where she is ...
(Date:5/25/2016)... ... ... For more than fifty years, we've suffered whiplash as each new scientific study seemed to ... latest nutritional advice – advice that was supposed to keep us healthy and slim. And ... adults are considered to be overweight and more than 1 in 3 adults are considered ...
(Date:5/25/2016)... , ... May 25, 2016 , ... "FCPX LUT Intense ... of your footage," said Christina Austin - CEO of Pixel Film Studios. , ... quickly and easily add stylish color grades to their footage. A LUT is a ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... May 24, 2016 Een app ... zodat zij collectief patiënten kunnen behandelen, hun kennis kunnen ... idee achter de nieuwe en revolutionaire MDLinking App, ontwikkeld ... Nederlandse vaatchirurg dr. Hans Flu en oncologisch chirurg dr. ... inmiddels beschikbaar is, wordt op dinsdag 24 mei officieel ...
(Date:5/23/2016)... FLINT, Mich. , May 23, 2016 Diplomat ... the third annual Fellowship and Internship programs. The hands-on ... 12. The full-time, paid Fellowship ... Flint, Michigan . Fellows and interns are ... downtown Flint at the Riverfront ...
(Date:5/23/2016)... , May 23, 2016 ... Devices, Diagnostics and Monitoring, and Vision Care ... Which areas are going to grow at the fastest ... revenues to 2026, assessing data, trends, opportunities and prospects. ... charts, and graphs. Discover the most lucrative areas in ...
Breaking Medicine Technology: