Navigation Links
Hormone-Boosting Drug May Help Treat Frailty

Older adults who took capromorelin had boost in lean body mass

TUESDAY, Jan. 27 (HealthDay News) -- A drug designed to increase the body's production of growth hormone may help treat frailty in older adults, a new study shows.

Older adults have greatly reduced production of growth hormone, which regulates metabolism and helps build muscle mass. Age-related decreases in strength and physical agility can led to disability and loss of independence.

"By boosting the production of growth hormones, we may be able to slow this process and help people lead active lives longer," study first author Dr. Heidi K. White, an associate professor of medicine at Duke University Medical Center, said in a Duke news release.

The study included 395 women and men, aged 65 to 84, with mild physical function limitations. They were randomly selected to take either a placebo or one of four doses of the investigational drug capromorelin. All four doses of the drug increased growth hormone production, and the findings were sustained over one year of treatment.

The researchers also found that participants who took the drug showed a significant increase in lean body mass (1.4 kilograms vs. 0.3 kg for placebo) and improvements in two physical function tests -- tandem walking (heel to toe) and stair climbing. Fatigue, insomnia and small increases in fasting glucose and HbA1c scores were among the side effects noted among those who took the drug.

The findings were released online and were expected to be published in the April issue of The Journal of Clinical Endocrinology & Metabolism. The study was funded by Pfizer, which developed capromorelin.

While the results suggest that stimulating growth hormone production can increase the body's ability to develop lean muscle, the physical improvements seen in the study were relatively mild.

For example, the patients who took the drug showed a 7 percent increase in their ability to climb stairs. A previous study found that a home-based exercise program among a similar patient population achieved a 23 percent to 24 percent improvement in stair-climbing ability after 10 weeks.

"Following further investigation, capromorelin could be used in combination with exercise," White suggested.

More information

The AGS Foundation for Health in Aging has more about physical activity.

-- Robert Preidt

SOURCE: Duke University Medical Center, news release, Jan. 27, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Using coxibs and NSAIDs to treat osteoarthritis
2. New treatment effective in counteracting cocaine-induced symptoms
3. New treatment boosts muscle function in myasthenia gravis
4. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
5. Free distribution of insecticide-treated mosquito nets can save lives
6. Kenyan malaria success strengthens call for free insecticide-treated nets for all
7. Broad-based group of physicians calls for improvement in stroke treatment
8. Cranberry Could Juice Up Ovarian Cancer Treatment
9. Is 4 agents decoction (Si Wu Tang) efficacious in treating primary dysmenorrhea?
10. Non-medicinal treatment touted for pre-schoolers with ADHD
11. Nonmedicinal treatment touted for preschoolers with ADHD
Post Your Comments:
Related Image:
Hormone-Boosting Drug May Help Treat Frailty 
(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/27/2016)... ... June 27, 2016 , ... recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: