Navigation Links
Hormonal Drugs Cool Hot Flashes From Prostate Cancer Therapy
Date:12/7/2009

Medroxyprogesterone wins out in comparison study

SUNDAY, Dec. 6 (HealthDay News) -- Hot flashes caused by androgen suppression therapy for prostate cancer are best controlled by the hormonal treatments cyproterone acetate and medroxyprogesterone acetate, according to a new study.

Androgen suppression is considered the gold standard treatment for advanced prostate cancer, but about 80 percent of patients undergoing the treatment experience hot flashes. A number of hormonal and non-hormonal drugs are used to treat the hot flashes, but no direct comparisons of the drugs have been made in clinical trials.

The new study included 311 prostate cancer patients in France undergoing androgen suppression therapy. To treat their hot flashes, they received either the non-hormonal drug venlafaxine (102 men), or one of two hormonal drugs -- cyproterone acetate (101 men) or medroxyprogesterone acetate (108 men). The patients were assessed at weeks four, eight and 12 and asked to complete a questionnaire about the frequency and severity of their hot flashes for the week before each assessment.

The researchers found that all three drugs reduced the occurrence of hot flashes, but the hormonal drugs were much more effective at reducing them over all time periods.

After receiving treatment for four weeks, 219 patients (nearly 71 percent) reported an improvement of at least 50 percent in their hot flash scores, and 70 patients (nearly 23 percent) said they no longer had hot flashes. By the fourth week, hot flash scores were reduced by 47.2 percent for the venlafaxine group, 83.7 percent for the medroxyprogesterone acetate group and 94.5 percent for the cyproterone acetate group.

Among men receiving gonadotrophin-releasing hormone analogue therapy for prostate cancer, cyproterone acetate and medroxyprogesterone acetate are more effective at 12 weeks for treating hot flashes, the researchers concluded. However, "as cyproterone is a recognized treatment in prostate cancer, and its use could interfere with hormone therapy, medroxyprogesterone should be the standard treatment," they wrote.

The study will be published online Dec. 7 in The Lancet Oncology.

More information

The American Urological Association has more about androgen suppression therapy for prostate cancer.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Dec. 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Dr. Rabin Introduces a Bioidentical Hormones Program Adaptable to Individual Body and Hormonal Needs
2. When it Comes to Natural Remedies for Hormonal Balance, the Proof is in the Clinical Research
3. Attorneys Learn of the Association Between Traumatic Brain Injury, Hormonal Deficiencies, Depression, and Heart Attacks
4. Hormonal Therapies Offer Effective Solutions for Many Adult Women With Acne
5. Pregnancy-related hormonal changes linked to increased risk of restless legs syndrome
6. Non-Hormonal Therapies Aid Breast Cancer Patients
7. Inheritance of hormonal disorder marked by excessive insulin in daughters
8. Synovics Pharmaceuticals Announces Execution of Hormonal Manufacture and Supply Contract
9. Iressa shows promise for treatment of metastatic breast cancer when combined with hormonal therapy
10. Hormonal dietary supplements might promote prostate cancer progression
11. Hormonal Changes and Depression: What is the Connection?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... , ... February 22, 2017 , ... ... regenerative medicine in recent years. The technology is so cutting edge, in fact, ... the protocol for stem cell procedures. However, successful patient outcomes in certain clinical ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... its certification exam and eligibility requirements effective with the April 2017 testing period. ... 1995. , “The Care Manager Certified (CMC) exam is periodically re-calibrated to ...
(Date:2/22/2017)... ... February 22, 2017 , ... VitreosHealth ... each Medicare Advantage member’s risk, identify any gaps-in-coding, as well as gaps-in-care ... transform the HCC Risk Adjustment process from a typical fragmented process to ...
(Date:2/22/2017)... ... February 22, 2017 , ... Doctors on Liens is continuing its steady expansion ... H. Rauchman, practicing at North Valley Eye Medical Group in Mission Hills . ... and other personal injury cases. These injuries have a major impact on the ...
(Date:2/22/2017)... ... February 22, 2017 , ... Using the power of the internet, ... online checklist. Over a period of just 24 months, thousands of individuals interested in ... checklist called T.A.D. , “The internet is not getting quieter. In fact it’s becoming ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Group, Inc. (NASDAQ: MDXG), the leading regenerative medicine company ... and market advanced products and therapies for the Wound ... sectors of healthcare, today announced its record results for ... 2016. Full Year 2016 Highlights are: ... full year 2015 revenue ...
(Date:2/23/2017)...   SeraCare Life Sciences , a manufacturer ... manufacturers and clinical laboratories, is announcing an upcoming ... Tests" to be hosted by GenomeWeb ... Standard Time (US). The goal of ... improved performance and global standardization in the implementation ...
(Date:2/23/2017)... , February 23, 2017 The U.S. ... legalized cannabis for recreational use in 2016. According to a ... market was worth an estimated $7.2 billion in 2016 and ... of 17%. While adult recreational sales are projected to jump ... with a 25% CAGR. The market may grow faster as ...
Breaking Medicine Technology: