Navigation Links
Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
Date:9/12/2012

ennifer Van Eyk, Ph.D., director of the Johns Hopkins Proteomics Innovation Center in Heart Failure.

In the current study, the team analyzed tissue from the hearts of patients with end-stage heart failure and from deceased healthy heart donors. The 14 sites the researchers identified are sites where troponin I binds with phosphate, a process known as phosphorylation. Phosphate can activate or deactivate many enzymes, thus altering the function of a protein and, in the case of heart failure, ignite disease. The six newly identified sites represent new "hot spots" involved in heart contraction, the researchers say, and could be used as diagnostic markers or a target for treatment to restore function. The Hopkins researchers found that in some sections of the molecule, phosphorylation ratcheted up the dimmer switch, while ratcheting it down in other sections, but it invariably led to muscle dysfunction.

"Our goal would be to zero in on these new sites, gauge risk of heart failure and, hopefully, restore heart muscle function," Van Eyk says.

Heart failure is a complex progressive disorder, and while cardiac pacemakers can restore or "resynchronize" heart function in many people, about one-third of patients do not improve even with pacemaker therapy in addition to standard medication treatments.

"This is a devastating disorder for which we desperately need new and less invasive therapies," says senior investigator Anne Murphy, M.D., a cardiologist at Johns Hopkins Children's Center.

In their analysis, the researchers used a novel technique, called multiple-reaction monitoring (MRM), which pinpoints the exact locations along the protein's molecule where faulty signaling occurs and disrupts heart muscle function. MRM is an ultra-sensitive type of mass spectrometry that measures the exact size and chemical composition of protein fragments. Phosphorylated protein fragments have different molecular weights than non-phosphorylat
'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Johns Hopkins Armstrong Institute receives $8.9 million patient safety grant
2. Johns Hopkins team finds ICU misdiagnoses may account for as many annual deaths as breast cancer
3. Johns Hopkins researchers return blood cells to stem cell state
4. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
5. 29 Johns Hopkins stem cell researchers awarded funding
6. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
7. Gladstone scientists develop technique to decipher the dormant AIDS virus concealed in cells
8. Reconstructed 1918 influenza virus has yielded key insights, scientists say
9. Scientists put a pox on dog cancer
10. MBL and Stanford scientists receive 2012 Lasker Award for Basic Medical Research
11. Scientists Inch Closer to Genetic Blueprint of Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... How well patients recover from cancer surgery ... conditions and the operations themselves. Family conflicts and ... surgical complications, a Mayo Clinic study has found. ... reduce patients, stress, speed their recoveries and save ... specifically looked at colon cancer patients, and found ...
(Date:9/2/2014)... care for patients who are dying. A study of ... in training feel unprepared and anxious when faced with ... Scientists from the Sahlgrenska Academy have interviewed 222 nursing ... Skvde and the Ersta Skndal University College. The interviews ... their ideas about how to support and meet the ...
(Date:9/2/2014)... 02, 2014 Nanomedicine is essentially ... diagnosing, treating and/or prevention of diseases and infections. ... cardiovascular, neurological, and oncology diseases. , Nanomedicine ... to various nanoparticles, their medical usages, and their ... considerable scope for research in this domain, and ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 The performance ... fluctuated over the past five years. Industry revenue is ... 1.0% over the five years through 2014-15, following stabilised ... faced increasing external competition from alternate forms of gambling. ... other online gambling platforms have all become increasingly popular ...
(Date:9/2/2014)... The American Healthcare Documentation Professionals Group ... for its ICD-10 Medical Coding Bridge Program. The purpose ... of confidence to students who are seeking to launch ... faced with the uncertainty brought on by the federal ... October 1st, 2015. , AHDPG’s Free-Tuition Guarantee is simple ...
Breaking Medicine News(10 mins):Health News:Family conflicts, other non-physical worries before cancer surgery raise patients' complication risk 2Health News:Many nurses unprepared to meet dying patients 2Health News:Nanomedicine Market: An Overview of Growth Factors and Future Prospects by Transparency Market Research 2Health News:Nanomedicine Market: An Overview of Growth Factors and Future Prospects by Transparency Market Research 3Health News:Lotteries in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Lotteries in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:American Healthcare Documentation Professionals Group (AHDPG) Launches Free-Tuition Guarantee for Its ICD-10 Medical Coding Bridge Program 2Health News:American Healthcare Documentation Professionals Group (AHDPG) Launches Free-Tuition Guarantee for Its ICD-10 Medical Coding Bridge Program 3
... ... and its staff members are helping to prepare Certified Professional Coders to meet the upcoming ... ... , a medical billing and practice management company, is pleased to announce that two of ...
... ... respirators universally fit faces, providing a better seal. Our product is available for retail ... our website. , ... Baxter, MN (PRWEB) October 9, 2009 -- Breathe Safely of Baxter Minnesota has created ...
... Sarasota Memorial ... application allows for voice, alarm and text messages to be delivered to the point of ... they have more time to spend caring for patients. , ... Sarasota,Fla (PRWEB) October 9, 2009 --Trey Lauderdale, Vice President ...
... Discussions Also to Feature Top Experts on the Battle Against H1N1 ... reform headed to the floor of the House and Senate, the ... discussions designed to shed light on what the looming changes will ... the Top of the Hill Banquet and Conference Center, at the ...
... time you run nutritionals using the government,s database, you might ... to have received a nutrient boost, virtually overnight. , The ... food entries - including mushrooms, the only fruit or vegetable ... updates made to the United States Department of Agriculture,s (USDA) ...
... League Baseball players have just learned they,re in the running for ... of 10 players, one of whom will go on to receive ... in January. The finalists for the 45th annual Hutch Award are: ... Torii Hunter, Los Angeles Angels of Anaheim Mark Lowe, ...
Cached Medicine News:Health News:Capture Billing Associates Elected to Local Chapter of the American Academy of Professional Coders 2Health News:Breathe Safely, LLC: Making Respirators 270% More Effective 2Health News:Sarasota Memorial Hospital Uses New Technology to Enhance Patient Experience 2Health News:Sarasota Memorial Hospital Uses New Technology to Enhance Patient Experience 3Health News:Tom Daschle, Richard Gephardt and Other Health Care Leaders to Diagnose Health Care Reform Battle in the Final Days of the Debate 2Health News:Tom Daschle, Richard Gephardt and Other Health Care Leaders to Diagnose Health Care Reform Battle in the Final Days of the Debate 3Health News:National Nutrient Database Updated to Include Vitamin D Values 2Health News:National Nutrient Database Updated to Include Vitamin D Values 3Health News:National Nutrient Database Updated to Include Vitamin D Values 4Health News:Ten Finalists Chosen for Hutch Award(R) 2
(Date:9/2/2014)... Sept. 2, 2014   Mast Therapeutics, Inc . (NYSE MKT: ... M. Culley , will present at the Rodman and Renshaw 16 ... at 2:55 p.m. Eastern time in the Holmes II Salon at ... . Interested parties can access a live audio ... www.masttherapeutics.com . An archived presentation will be available on the ...
(Date:9/2/2014)...  BioSpecifics Technologies Corp. (NASDAQ: BSTC ), a ... XIAFLEX ® in the U.S. and XIAPEX ® ... Wegman , will present at the following upcoming investor conferences. ... & Renshaw 16 th Annual Global Investment Conference ... 9, 2014 at 9:10 a.m. EDT , Aegis ...
(Date:9/2/2014)...  MEI Pharma, Inc. (Nasdaq: MEIP ... development of novel therapies for cancer, announced today ... Phase II clinical trial of its lead investigational ... patients with previously untreated intermediate-2 or high-risk myelodysplastic ... a total of 108 patients with a one-to-one ...
Breaking Medicine Technology:Mast Therapeutics To Present At The Rodman And Renshaw 16th Annual Global Investment Conference On September 9th 2Mast Therapeutics To Present At The Rodman And Renshaw 16th Annual Global Investment Conference On September 9th 3BioSpecifics Technologies Corp. Announces Presentations at Upcoming Investor Conferences 2MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 2MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 3MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 4
... May 24, 2012   Hospira, Inc.  (NYSE: ... injectable drugs and infusion technologies, today released a ... integration of infusion pumps and electronic health records ... which recognizes the important work of healthcare technology ...
... Volcano Corporation (NASDAQ: VOLC ), a leading ... enhance the diagnosis and treatment of coronary and peripheral vascular ... Jefferies 2012 Global Healthcare Conference on Monday, June 4. ... begin at 8 a.m., Eastern Daylight Time (5 a.m., Pacific ...
Cached Medicine Technology:I.V. Clinical Integration Helps Deliver Safety, Efficiency And Financial Benefits; Hospira Shares Snapshot Of Results, Process 2I.V. Clinical Integration Helps Deliver Safety, Efficiency And Financial Benefits; Hospira Shares Snapshot Of Results, Process 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: