Navigation Links
Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
Date:9/12/2012

A new Johns Hopkins study has unraveled the changes in a key cardiac protein that can lead to heart muscle malfunction and precipitate heart failure.

Troponin I, found exclusively in heart muscle, is already used as the gold-standard marker in blood tests to diagnose heart attacks, but the new findings reveal why and how the same protein is also altered in heart failure. Scientists have known for a while that several heart proteins troponin I is one of them get "out of tune" in patients with heart failure, but up until now, the precise origin of the "bad notes" remained unclear.

The discovery, published online ahead of print on Sept. 12 in the journal Circulation, can pave the way to new and badly needed diagnostic tools and therapies for heart failure, a condition marked by heart muscle enlargement and inefficient pumping, and believed to affect more than 6 million adults in the United States, the researchers say.

Troponin I acts as an on-off switch in regulating heart relaxation and contraction and, in response to, adrenaline the "flight-fight" response. But when altered, troponin I can start acting as a dimmer switch instead, one that ever so subtly modulates cardiac muscle function and reduces the heart's ability to pump efficiently and fill with blood, the researchers found.

The Hopkins team used a novel method to pinpoint the exact sites, or epicenters, along the protein's molecule where disease-triggering changes occur. They found 14 such sites, six of them previously unknown. In revealing new details about the molecular sequence of events leading up to heart failure, the researchers said their work may spark the development of tests that better predict disease risk and monitor progression once the heart begins to fail.

"Our findings pinpoint the exact sites on troponin I's molecule where disease-causing activity occurs, and in doing so they give us new targets for treatment," says researcher J
'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Johns Hopkins Armstrong Institute receives $8.9 million patient safety grant
2. Johns Hopkins team finds ICU misdiagnoses may account for as many annual deaths as breast cancer
3. Johns Hopkins researchers return blood cells to stem cell state
4. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
5. 29 Johns Hopkins stem cell researchers awarded funding
6. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
7. Gladstone scientists develop technique to decipher the dormant AIDS virus concealed in cells
8. Reconstructed 1918 influenza virus has yielded key insights, scientists say
9. Scientists put a pox on dog cancer
10. MBL and Stanford scientists receive 2012 Lasker Award for Basic Medical Research
11. Scientists Inch Closer to Genetic Blueprint of Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... August 02, 2015 , ... Back packs can be dangerous? ... however, back packs can wreck havoc on a kid's spine. With school starting again, ... and from school. Make sure you are aware of how to help them prevent ...
(Date:8/1/2015)... , ... August 01, 2015 , ... Calvary Hospital today ... housed at their Bronx campus. The goal is to bring this Torah – dating ... used in Jewish rituals and religious services. , Scroll No. 515, from the ...
(Date:8/1/2015)... York, NY (PRWEB) , ... August 01, 2015 , ... ... Vine cyberespionage group , who are thought to have been behind the attack on ... the topics covered were zero day exploits, watering hole attacks and spear phishing campaigns. ...
(Date:8/1/2015)... CT (PRWEB) , ... August 01, 2015 , ... On March 19, 2015 Phil Valentine ... mile trek of the Appalachian Trail by stepping off Springer Mountain and heading ... , On July 26th Phil reached Connecticut and was greeted by friends and family. ...
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, ... on the Future of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. ... this meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit ...
Breaking Medicine News(10 mins):Health News:Local AlignLife Doctor Donates Time to Check Back Packs 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4
... Anthony Movshon, director of New York University,s Center for ... 2010 Antnio Champalimaud Vision Award for his work on ... announced today. Movshon shares the award with William T. ... Vision Award comes with a $1.3 million prize, the ...
... is examining a sequence of DNA- known as telomeres - ... that these structures shrink in length over an individual,s lifetime ... commonly associated with ageing and, perhaps most importantly, the development ... how this process is controlled. Jonathan Williams, from the ...
... club, they gain a stronger sense of who they are ... The study suggests that even small improvements in self ... trouble. "The more kids participate in these clubs, the ... professor of social work at Ohio State. "And then that ...
... Structural Genomics Consortium (SGC) and Pfizer today announced that ... small molecule inhibitors "chemical probes" for proteins ... are now members of this collaboration, launched in late ... high quality research reagents, free from restriction on use. ...
... 2010 -- The 5th ESU Master class on medical treatment ... Urology (ESU) on 25-27 June 2010 at the Barcel Hotel ... prime venue to scrutinise current practices and survey the latest ... medical disciplines involved in cancer therapy. It is open to ...
... the open access option for participating journals fell to 5.9%, compared ... uptake amongst 11 new titles joining Oxford Open in 2009. On ... entered the scheme prior to 2008 was stable (6.7%, compared with ... Oxford Open prior to 2008, by broad subject area the highest ...
Cached Medicine News:Health News:NYU's Movshon receives Champalimaud Vision Award for work on how brain reconstructs images 2Health News:Size matters -- when it comes to DNA 2Health News:Youth clubs strengthen kids' self image to keep them out of trouble 2Health News:Youth clubs strengthen kids' self image to keep them out of trouble 3Health News:Pfizer joins open-access medicinal chemistry public-private collaboration 2Health News:5th ESU Master Class on Medical Treatment for Urological Cancer 2
(Date:7/31/2015)... July 31, 2015 Today, the National ... ® ) issued a report urging greater accountability ... is taken against websites illegally selling medications online. ... Outlet Identification Program Progress Report for State and ... thousands of websites illegally distribute medications and avoid ...
(Date:7/31/2015)... 31, 2015 According to a new ... Heat, Dry Heat, Ethylene Oxide, Filtration, E-beam, Gamma), Services (Onsite ... Pharmaceuticals) - Global Forecast to 2020", published by MarketsandMarkets, The ... Billion by 2020, at a CAGR of 7.6%.from 2015 to ... market data T ables and 37 ...
(Date:7/31/2015)... 31, 2015  Semler Scientific, Inc. (Nasdaq: SMLR ... to healthcare insurers and physician groups, today reported financial ... "In the second quarter of 2015, ... growth of 54%, quarter over quarter revenue growth of ... base of FloChec® units of 18%," said Doug Murphy-Chutorian, ...
Breaking Medicine Technology:NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4Semler Reports Second Quarter 2015 Financial Results 2Semler Reports Second Quarter 2015 Financial Results 3Semler Reports Second Quarter 2015 Financial Results 4Semler Reports Second Quarter 2015 Financial Results 5Semler Reports Second Quarter 2015 Financial Results 6
...  Halo Therapeutics, LLC, a clinical-stage biopharmaceutical company developing ... that the United States Food and Drug Administration ... treatment of Duchenne muscular dystrophy (DMD). DMD is ... approximately 1 in 3,500 boys worldwide. HT-100, also ...
... 4, 2012  Elevation Pharmaceuticals, Inc. announced today the closing ... investor Novo Ventures , to fund development of Elevation,s ... disease (COPD). All previous investors participated in the round, including ... Capital and Mesa Verde Venture Partners . In ...
Cached Medicine Technology:Halo Therapeutics' HT-100 Receives FDA's Orphan Designation for Duchenne Muscular Dystrophy 2Halo Therapeutics' HT-100 Receives FDA's Orphan Designation for Duchenne Muscular Dystrophy 3Elevation Pharmaceuticals Completes $30 Million Series B Financing to Advance Aerosol COPD Therapy 2Elevation Pharmaceuticals Completes $30 Million Series B Financing to Advance Aerosol COPD Therapy 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: