Navigation Links
Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
Date:9/12/2012

A new Johns Hopkins study has unraveled the changes in a key cardiac protein that can lead to heart muscle malfunction and precipitate heart failure.

Troponin I, found exclusively in heart muscle, is already used as the gold-standard marker in blood tests to diagnose heart attacks, but the new findings reveal why and how the same protein is also altered in heart failure. Scientists have known for a while that several heart proteins troponin I is one of them get "out of tune" in patients with heart failure, but up until now, the precise origin of the "bad notes" remained unclear.

The discovery, published online ahead of print on Sept. 12 in the journal Circulation, can pave the way to new and badly needed diagnostic tools and therapies for heart failure, a condition marked by heart muscle enlargement and inefficient pumping, and believed to affect more than 6 million adults in the United States, the researchers say.

Troponin I acts as an on-off switch in regulating heart relaxation and contraction and, in response to, adrenaline the "flight-fight" response. But when altered, troponin I can start acting as a dimmer switch instead, one that ever so subtly modulates cardiac muscle function and reduces the heart's ability to pump efficiently and fill with blood, the researchers found.

The Hopkins team used a novel method to pinpoint the exact sites, or epicenters, along the protein's molecule where disease-triggering changes occur. They found 14 such sites, six of them previously unknown. In revealing new details about the molecular sequence of events leading up to heart failure, the researchers said their work may spark the development of tests that better predict disease risk and monitor progression once the heart begins to fail.

"Our findings pinpoint the exact sites on troponin I's molecule where disease-causing activity occurs, and in doing so they give us new targets for treatment," says researcher J
'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Johns Hopkins Armstrong Institute receives $8.9 million patient safety grant
2. Johns Hopkins team finds ICU misdiagnoses may account for as many annual deaths as breast cancer
3. Johns Hopkins researchers return blood cells to stem cell state
4. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
5. 29 Johns Hopkins stem cell researchers awarded funding
6. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
7. Gladstone scientists develop technique to decipher the dormant AIDS virus concealed in cells
8. Reconstructed 1918 influenza virus has yielded key insights, scientists say
9. Scientists put a pox on dog cancer
10. MBL and Stanford scientists receive 2012 Lasker Award for Basic Medical Research
11. Scientists Inch Closer to Genetic Blueprint of Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... lumpectomy followed by radiation therapy survived as long ... a large study conducted by researchers at the ... Prevention Institute of California. , The comprehensive analysis ... is the first to directly compare survival rates ... mastectomy (the removal of both breasts), unilateral mastectomy ...
(Date:9/2/2014)... the groundwork for their own spread throughout the body ... tumor-welcoming signals, according to a new report by Johns ... of Nature Communications , the researchers describe animal ... signaling molecules released by breast cancer cells. These molecules ... lymph nodes to produce proteins called CCL5 and VEGF. ...
(Date:9/2/2014)... 02, 2014 The Dream2Walk Foundation along with ... Sept. 14th, 2014 during Spinal Cord Injury Awareness Month featuring ... England, and Chuck Ligon. Linear Automotive will be there hosting ... , Doors open at 2pm. The car show is Pre ... free pass to the concert. There will be trophies for ...
(Date:9/2/2014)... 2014 (HealthDay News) -- Two new studies further confirm ... 6-year-olds who were breast-fed have a lower risk of ... while the other finds a similar trend when it ... benefits of breast-feeding in the immediate newborn period," said ... in New York City. She was not involved in ...
(Date:9/2/2014)... Steven Reinberg HealthDay Reporter ... device intended to help with weight loss by blocking a ... expectations in a trial among obese patients. Using electric ... brain and stomach, researchers hoped to suppress feelings of hunger. ... "A device that safely blocks the nerve that connects ...
Breaking Medicine News(10 mins):Health News:Breast cancer patients with bilateral mastectomy don't have better survival rates 2Health News:Breast cancer patients with bilateral mastectomy don't have better survival rates 3Health News:Breast cancer patients with bilateral mastectomy don't have better survival rates 4Health News:‘Prepped’ by tumor cells, lymphatic cells encourage breast cancer cells to spread 2Health News:Gas Monkey Hosts Concert in Dallas Benefiting Dream2Walk Foundation with Linear Automotive 2Health News:More Evidence Breast-Feeding Lowers Child's Risk of Infections, Allergies 2Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 2Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 3
... 1 issue of the journal Sleep describes how changes ... age affect cognitive function in later life. The findings suggest that ... to 8 hours per night are subject to an accelerated cognitive ... Results show that the sleep duration at follow-up of 7.4 ...
... who care for patients with dementia now have a ... to a pilot study by a team of nurses. ... disease as well as periodontal disease," said Rita A. ... with the mouth. According to Jablonski, assistant professor of ...
... , SATURDAY, April 30 (HealthDay News) -- A new ... and white women may predict increased arterial stiffness, which is ... to work harder to pump blood and are also associated ... can block blood flow and lead to a heart attack. ...
... 30, 2011) The Osteopathic Heritage Foundations, $105 million award ... private donation ever given to a college or university in ... of the most pressing health care issues across the state ... physicians and the diabetes epidemic. The transformational gift was ...
... HealthDay Reporter , FRIDAY, April 29 (HealthDay News) -- ... surgery or surgery plus radiation, and radiation is widely believed ... researchers report that they have found that surgery plus radiation ... of invasive breast cancers later. "I don,t want people ...
... DENVER Parents who give young children prescription painkillers should ... right amount. What they may be surprised to learn, however, ... could be too high, according to research to be presented ... meeting in Denver. Researchers from South Carolina identified the ...
Cached Medicine News:Health News:Adverse changes in sleep duration are associated with lower cognitive scores in middle-aged adults 2Health News:Adverse changes in sleep duration are associated with lower cognitive scores in middle-aged adults 3Health News:Dirty mouths lead to broken hearts 2Health News:Record funding award given to Ohio University College of Osteopathic Medicine 2Health News:Record funding award given to Ohio University College of Osteopathic Medicine 3Health News:Record funding award given to Ohio University College of Osteopathic Medicine 4Health News:Record funding award given to Ohio University College of Osteopathic Medicine 5Health News:Breast Cancer Recurrence Rates Appear Different When Radiation Used 2Health News:Errors put infants, children at risk for overdose of painkillers 2
(Date:9/2/2014)... 2, 2014 Reportbuyer.com has added a ... and Technologies for Molecular Imaging Devices ... OBJECTIVES The objectives of this study are ... devices used for diagnostic purposes, present global market ... possible market segments as well as forecast market ...
(Date:9/2/2014)... 2, 2014 Reportbuyer.com has added a ... Global Markets for Services and Devices ... Bariatric surgery or weight loss surgery is a ... processes that deal with the surgical treatment of ... (endoluminal) and performed in both open and laparoscopic ...
(Date:9/2/2014)... -- Astellas has appointed James Kellerman as ... Americas. Kellerman will report directly to Linda Friedman ... In his new role, Kellerman will lead a team ... manage the region,s intellectual property matters, coordinating closely with ... pleased to welcome Jim to Astellas. Jim brings a ...
Breaking Medicine Technology:Global Markets and Technologies for Molecular Imaging Devices 2Global Markets and Technologies for Molecular Imaging Devices 3Global Markets and Technologies for Molecular Imaging Devices 4Global Markets and Technologies for Molecular Imaging Devices 5Global Markets and Technologies for Molecular Imaging Devices 6Global Markets and Technologies for Molecular Imaging Devices 7Global Markets and Technologies for Molecular Imaging Devices 8Global Markets and Technologies for Molecular Imaging Devices 9Global Markets and Technologies for Molecular Imaging Devices 10Global Markets and Technologies for Molecular Imaging Devices 11Global Markets and Technologies for Molecular Imaging Devices 12Global Markets and Technologies for Molecular Imaging Devices 13Global Markets and Technologies for Molecular Imaging Devices 14Global Markets and Technologies for Molecular Imaging Devices 15Global Markets and Technologies for Molecular Imaging Devices 16Global Markets and Technologies for Molecular Imaging Devices 17Global Markets and Technologies for Molecular Imaging Devices 18Global Markets and Technologies for Molecular Imaging Devices 19Global Markets and Technologies for Molecular Imaging Devices 20Global Markets and Technologies for Molecular Imaging Devices 21Global Markets and Technologies for Molecular Imaging Devices 22Global Markets and Technologies for Molecular Imaging Devices 23Global Markets and Technologies for Molecular Imaging Devices 24Global Markets and Technologies for Molecular Imaging Devices 25Bariatric Surgery: Global Markets for Services and Devices 2Bariatric Surgery: Global Markets for Services and Devices 3Bariatric Surgery: Global Markets for Services and Devices 4Bariatric Surgery: Global Markets for Services and Devices 5Bariatric Surgery: Global Markets for Services and Devices 6Bariatric Surgery: Global Markets for Services and Devices 7Bariatric Surgery: Global Markets for Services and Devices 8Bariatric Surgery: Global Markets for Services and Devices 9Bariatric Surgery: Global Markets for Services and Devices 10Bariatric Surgery: Global Markets for Services and Devices 11Bariatric Surgery: Global Markets for Services and Devices 12
... ... treatment, Dr. Carl Giordano - based in Morristown - among first surgeons ... ... N.J., July 29 Leading New Jersey orthopedic,surgeon Dr. Carl Giordano, of Morristown-based Atlantic ...
... Md., July 29 Micromet, Inc.,(Nasdaq: MITI ... the treatment of cancer, inflammation and autoimmune,diseases, today ... and audio,webcast on Thursday, August 7, 2008, at ... to discuss its second quarter 2008 financial,results. Micromet ...
Cached Medicine Technology:NJ-Based Surgeon Helps Pioneer Dramatic Advance in Treating Damaged Discs 2Micromet, Inc. to Host Conference Call and Webcast to Discuss Second Quarter 2008 Financial Results 2Micromet, Inc. to Host Conference Call and Webcast to Discuss Second Quarter 2008 Financial Results 3
AxSYM Plus provides cutting-edge ergonomics and smart new features that mean increased ease-of-use and enhanced reliability. Also, advanced software means less operator intervention and high-integrit...
The ADx system uses fluorescence polarization immunoassay technology for the detection of abused drugs and toxicology assays....
The UniCel DxI 800 with its exceptional throughput, proven chemiluminescent technology, assay protocols like Access, Access 2, Synchron LXi 725 and load "on-the-fly" capability simplifies and automat...
...
Medicine Products: