Navigation Links
Hopkins scientists create method to personalize chemotherapy drug selection
Date:2/14/2013

In laboratory studies, scientists at the Johns Hopkins Kimmel Cancer Center have developed a way to personalize chemotherapy drug selection for cancer patients by using cell lines created from their own tumors.

If the technique is successful in further studies, it could replace current laboratory tests to optimize drug selection that have proven technically challenging, of limited use, and slow, the researchers say.

Oncologists typically choose anticancer drugs based on the affected organs' location and/or the appearance and activity of cancer cells when viewed under a microscope. Some companies offer commercial tests on surgically removed tumors using a small number of anticancer drugs. But Anirban Maitra, MBBS, professor of pathology and oncology at the Johns Hopkins University School of Medicine, says the tissue samples used in such tests may have been injured by anesthetic drugs or shipping to a lab, compromising test results.

By contrast, he says "our cell lines better and more accurately represent the tumors, and can be tested against any drug library in the world to see if the cancer is responsive."

The Johns Hopkins scientists developed their test-worthy cell lines by injecting human pancreatic and ovarian tumor cells into mice genetically engineered to favor tumor growth. Once tumors grew to one centimeter in diameter in the mice, the scientists transferred the tumors to culture flasks for additional studies and tests with anticancer drugs.

In one experiment, they successfully pinpointed the two anticancer drugs from among more than 3,000 that were the most effective in killing cells in one of the pancreatic cancer cell lines. A report on the success was published online Jan. 22 in the journal Clinical Cancer Research.

The new method was designed to overcome one of the central problems of growing human tumor cell lines in a laboratory dish -- namely the tendency of noncancerous cel
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. 29 Johns Hopkins stem cell researchers awarded funding
2. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
3. Johns Hopkins researchers return blood cells to stem cell state
4. Johns Hopkins team finds ICU misdiagnoses may account for as many annual deaths as breast cancer
5. Johns Hopkins Armstrong Institute receives $8.9 million patient safety grant
6. Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
7. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
8. In US first, Johns Hopkins surgeons implant brain pacemaker for Alzheimers disease
9. Johns Hopkins study reveals what makes nonprofits special
10. Fasting may benefit patients with epilepsy, Johns Hopkins Childrens Center study suggests
11. Johns Hopkins to aid The Leapfrog Group in grading the safety and quality of US hospitals
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hopkins scientists create method to personalize chemotherapy drug selection
(Date:5/25/2013)... 25, 2013 Studies from Johns Hopkins ... carrying excessive weight and their inability to get adequate ... losing weight can naturally relieve many symptoms. , ... in sleep quality was significantly associated with overall weight ... study dated November 6th, 2012, researchers monitored 77 ...
(Date:5/25/2013)... Absolute Surgical Specialists, serving Sun City Center ... businesses throughout the country participating in Shop Local for a ... nationwide event as he understands what military families go through ... He said, “I wanted to give something back, as I ... live here too.” , Shop Local for a Cause has ...
(Date:5/25/2013)... York, New York (PRWEB) May 25, 2013 ... who allegedly suffered serious, life-threatening episodes of internal bleeding while ... litigation underway in U.S. District Court, Southern District of Illinois, ... the Court’s website, 818 Pradaxa side effect claims had ... 2013. That’s up from 705 claims reported by the ...
(Date:5/25/2013)... By working diligently for months on ... of the 2012 Lamborghini Aventador into their well-built fitments ... in the list of vehicles lined by SizeItUp for ... set to thrill automobile lovers in the year 2013. ... looks, the 2012 Lamborghini Aventador comes with extraordinarily spacious ...
(Date:5/25/2013)... (PRWEB) May 25, 2013 According ... Emergency Management Market, 2013–2018", published by MarketsandMarkets is ... a CARC of 5.54% which analyzes and studies ... North America, Europe, Asia, and Rest of the ... Market Data Tables , 87 Figures ...
Breaking Medicine News(10 mins):Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Newly Improved hCG Diet Plans Capable of Delivering Better Sleep 2Health News:Dr. Craig Amshel of Absolute Surgical Specialists Offering Bowel Prep During the Shop Local for a Cause Event 2Health News:Pradaxa Lawsuits Mount, as Filings in Federal Pradaxa Side Effect Litigation Exceed 800, Bernstein Liebhard LLP Reports 2Health News:Pradaxa Lawsuits Mount, as Filings in Federal Pradaxa Side Effect Litigation Exceed 800, Bernstein Liebhard LLP Reports 3Health News:Rim Fitments Provider SizeItUp Launches The Database Integration For The 2012 Lamborghini Aventador 2Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 2Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 3Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 4
... Garca Navarro, a researcher at the School of Pharmacy at ... colon and liver cancer. The new treatment has shown ... ,This discovery is the principal result of her doctoral ... Cancer Cells of the Colon, which was subsidized by the ...
... who suffer bouts of nausea and vomiting during their pregnancies ... but it seems that going through morning sickness is a ... who have conducted a new study and found that women ... risk of developing breast cancer later in life than expecting ...
... shown a decline, thanks to the comprehensive program in 2002, ... 2006 report shows a decline in the smoking rate ... past year, smoking decreased among men (from 22.5% to 19.9%) ... followed a year-long ad campaign aimed at prompting more smokers ...
... cause effects ranging from learning and memory capabilities to ... of St.Jude Childrens Research hospital . ... factora molecule that binds to a section of DNA near ... protein for which it codes. CREB activates genes in response ...
... who allegedly tried to get his 15-year-old son into the record ... said the accusation was a ploy by his detractors to defame ... a video recording of his son Dhileepan Raj, a tenth standard ... other doctors in the hope of making his son attain the ...
... occurs as a solid tumor in the abdomen, but ... the network of the body's sympathetic nervous system. ... neuroblastoma is a special case, accounting for 7 percent ... cancer deaths. ,Neuroblastoma is what physicians ...
Cached Medicine News:Health News:Novel Treatment Beneficial for Colon and Liver Cancer 2Health News:Morning Sickness may Signify Lower Breast Cancer Risk 2Health News:Morning Sickness may Signify Lower Breast Cancer Risk 3Health News:New York Records Decline in Smoking Rate 2Health News:Research Studies on Molecular Switches of Gene 2Health News:The Bottleneck in Neuroblastoma 2
(Date:5/24/2013)... , May 24, 2013 In accordance with ... and Rule 14e-1 of the United States Exchange Act, Echo ... original offer for Elan Corporation (NYSE: ELN). Background ... ("Royalty Pharma") made an offer for the entire of the ... plc ("Elan") (the "Original Offer").  On 20 ...
(Date:5/23/2013)... 2013 3SBio Inc. (NASDAQ: ... China -based biotechnology company focused ... announced today that, at an extraordinary general meeting ... in favor of the proposal to authorize and ... merger dated February 8, 2013, among Decade Sunshine ...
(Date:5/23/2013)... , May 23, 2013 Amgen (NASDAQ: ... th Annual  Healthcare Conference on Thursday, May 30, 2013, ... , beginning at 9:20 a.m. Eastern Daylight Time. ... Amgen, will present at the conference. Live audio of the ... website, www.amgen.com , under Investors. A replay of the ...
Breaking Medicine Technology:Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 2Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 4Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 5Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 6Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 7Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 8Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 93SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3
Jewelers forceps. Insulated....
Semkin forceps with stops. Insulated....
Gerald bayonet forceps. Insulated....
Cushing forceps. Insulated....
Medicine Products: