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Hopkins researchers discover new link to schizophrenia
Date:5/8/2008

hese BACE1-lacking mice also displayed many other schizophrenia-like traits. Most importantly, according to Savonenko, some of the deficits improved after treatment with the antipsychotic drug clozapine.

Because schizophrenia is a disorder likely caused by many different factors, Savonenko explains that BACE1 might contribute to an increased risk of schizophrenia in certain patients and the BACE1 mice will be a useful animal model. We never thought we would see one mouse that closely mimics so many of the clinical features of schizophrenia, says Alena Savonenko, M.D., Ph.D., an assistant professor of neuropathology at Hopkins. This could be a really useful model to study and understand the molecular contributions to the disease.


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Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

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