Navigation Links
Hopes for AIDS Vaccine Still Alive Despite Setbacks
Date:12/1/2008

The lesson from 2 failed trials: The science must be more vigorous, experts say

MONDAY, Dec. 1 (HealthDay News) -- Nobody said HIV would give up without a fight.

As World AIDS Day arrives Dec. 1, scientists are taking a sobering look back at what went wrong in recent, high-profile failures of two human trials of candidate AIDS vaccines.

The consensus: A viable vaccine is still very possible, and with it comes the potential to wipe out HIV/AIDS. But the science behind any new candidate vaccine must be much stronger than it has been in the past before testing begins in humans.

"We are going to be better served to try and find out the basics of what the immune response is to HIV, what the limitations are, and how we can tweak or change that, or come up with something entirely new," said Rowena Johnston, vice president of research at the Foundation for AIDS Research (amFAR) in New York City. "And only then can we start to think about a product that could be taken into humans."

Just two potential HIV vaccines have made it so far to human clinical trials: VaxGen's AIDSVAX, tested in Thailand, until the trial was stopped in 2003; and Merck & Co.'s HIV vaccine, which was tested in North and South America, the Caribbean and Australia, until it proved a failure in 2007.

In the Merck case, the trial results have also been shadowed by speculations that the vaccine somehow tweaked some recipients' immune systems to make them slightly more vulnerable to HIV infection.

Some experts in the field now believe that both vaccines were rushed too soon into human trials. One big flaw: Primate trials matched the vaccine to the strain of HIV the monkey was exposed to. That's unlike "real world" human infections, where people may be randomly confronted with any number of strains, experts said.

"What you want to do is have evidence in primates that you can block completely, or ne
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Head Start Leaders Have High Hopes for New President and Congress, But Budget Double Whammy Expected to Force Cuts of Up to 14,000 Child Slots Nationwide
2. Twin findings raise hopes of improved anemia treatments
3. Hopes, Predictions and Realities: Is Biomedical Research Delivering On Its Promises?
4. Researchers test old drug with new hopes for pre-eclampsia cure
5. EpiVax Receives NIH Grant for $390,000 to Optimize HIV Vaccine Delivery
6. CVS Caremark Presents Influenza Vaccine Data at Rescheduled 2008 DMAA Annual Meeting
7. Researchers discover strategy for predicting the immunity of vaccines
8. CDC Monitors Shortage of Hib Vaccine
9. Medical societies: Adults need vaccines
10. Hepatitis C Therapeutic DNA Vaccine Delivered by Inovio Biomedical's Electroporation Technology Reduces Viral Load by Up to 99.7% : Clinical Data Presented at Annual Scientific Meeting of the American Association for the Study of Liver Diseases
11. HIV Vaccine Failure Still Brings Insights
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hopes for AIDS Vaccine Still Alive Despite Setbacks
(Date:4/17/2014)... (17 April 2014) Population Council scientists and their partners ... stable, and can prevent the transmission of multiple sexually ... in animals: HIV, herpes simplex virus 2 (HSV-2), and ... first data that the gel is effective against multiple ... in the vagina against all three viruses of at ...
(Date:4/17/2014)... and alleviates muscle soreness after exercise, according to ... Illinois at Chicago. , The study, reported online ... of Physical Medicine and Rehabilitation , also showed ... had not exercised, suggesting that massage has benefits ... activity. , Improved circulation and relief of muscle ...
(Date:4/17/2014)... cent of Canadians surveyed said they would participate in ... number of genetic conditions, only 80 per cent said ... would sequence their newborns, genomes.,Most newborns in North America ... or two of life in which a tiny amount ... for about five to 54 conditions, depending on the ...
(Date:4/17/2014)... status as the leading weapon against the deadly disease ... new research indicating it simply needs to be administered ... the cheap anti-malarial drug chloroquine in treating and preventing ... than half a million people each year around the ... resistance to chloroquine, but research carried out at the ...
(Date:4/16/2014)... The Translational Genomics Research Institute (TGen) recently honored two ... their support of TGen,s research into brain, colon and ... Scottsdale. , Catherine Ivy, Founder and President of The ... McCain Leadership Award, named for U.S. Sen. John McCain ...
Breaking Medicine News(10 mins):Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2Health News:Massage therapy improves circulation, eases muscle soreness 2Health News:Researcher looks at public perceptions around newborn testing 2Health News:Researcher looks at public perceptions around newborn testing 3Health News:Scientists find new way to fight malaria drug resistance 2Health News:TGen honors Catherine Ivy and Craig Jackson with Leadership; Collaborative Spirit awards 2
... blocks muscle growth, has shown promising results as a ... studies, where its inhibition led to increased muscle mass ... a myostatin inhibitor in patients, assessed its safety in ... well-tolerated. The study was published today in Annals of ...
... in Boone County to house world class research, center in country,s ... of personalized medicine into mainstream ... ... MHS ), joined by Indiana Gov. Mitch Daniels, broke,ground today on its ...
... Holdings Corp.,(Nasdaq: HMSY ) today announced that it ... which will be held March 26-27, 2008 at the ... of HMS Holdings Corp., will,present on Wednesday, March 26th ... HMSY ) is a national leader in cost,containment ...
... hospitals will aggravate existing problems, ... ... state legislators to reject a proposal to,eliminate the state,s planning process for ... huge cuts in,funding to care for the elderly and poor, and already ...
... recurrent or new tumors by more than half, study found ... good news for the 60 percent of women with breast ... inhibitor (AI) drug letrozole (Femara) can cut risk of a ... even when women initiated the drug one to seven years ...
... &,Johnson will participate in the Eleventh Annual Lehman ... the Loews Miami Beach Hotel,in Miami, Florida. Dominic ... represent the Company in a session scheduled at,11:15 ... available to investors and other interested parties,by accessing ...
Cached Medicine News:Health News:New potential treatment for muscular dystrophy appears to be safe 2Health News:Medco Breaks Ground For World's Largest Automated Pharmacy 2Health News:Medco Breaks Ground For World's Largest Automated Pharmacy 3Health News:Medco Breaks Ground For World's Largest Automated Pharmacy 4Health News:Medco Breaks Ground For World's Largest Automated Pharmacy 5Health News:Hospital Leaders Urge Legislators Not to Further Destabilize Florida's Healthcare Landscape 2Health News:Hospital Leaders Urge Legislators Not to Further Destabilize Florida's Healthcare Landscape 3Health News:Late Use of Aromatase Inhibitor Still Effective Against Breast Cancer 2Health News:Late Use of Aromatase Inhibitor Still Effective Against Breast Cancer 3
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
(Date:1/15/2014)... , Jan. 15, 2014  Novation, the leading health ... several new IT value-added reseller (VAR) national contracts that ... goods and services at lower costs. These include manufacturer ... such as initiative assistance and ongoing IT consulting support. ...
(Date:1/15/2014)... , Jan. 15, 2014 Massachusetts General Hospital ... AMGN ) announced today that they have ... validate new therapeutic targets and develop novel therapies ... that affects millions worldwide. The MGH-Broad-Amgen collaboration brings ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... 8, 2011 Reportlinker.com announces that a new ... Global Sepsis Therapeutics Industry ... This report analyzes the worldwide markets for ... sales of drugs used in the direct treatment ...
... Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ) ... (DAA) currently in Phase IIb development for hepatitis C, ... Most Interesting Infectious Disease Projects to Watch. ... Top 10 infectious disease project," said Kevin Eastwood, Anadys, ...
Cached Medicine Technology:Global Sepsis Therapeutics Industry 2Global Sepsis Therapeutics Industry 3Global Sepsis Therapeutics Industry 4Global Sepsis Therapeutics Industry 5Anadys' Setrobuvir Named One of Windhover's Top 10 Most Interesting Infectious Disease Projects to Watch 2Anadys' Setrobuvir Named One of Windhover's Top 10 Most Interesting Infectious Disease Projects to Watch 3Anadys' Setrobuvir Named One of Windhover's Top 10 Most Interesting Infectious Disease Projects to Watch 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: