Navigation Links
Hope for transplant patients as study finds key to organ scarring
Date:11/10/2013

Patients with damaged organs could be helped by new treatments after scientists have discovered how tissues scar.

Researchers say that the finding could pave the way for new drugs and eventually reduce the number of patients on organ transplant waiting lists.

Fibrotic diseases occur in many tissues within the body including the liver, lung or kidneys and have a range of causes including viruses or toxins. Experts say that the main source of scar tissue is found in specialised cells called Myofibroblasts.

The study discovered that a molecule on these cells is a key regulator of fibrotic disease.

Scientists say that the molecule called alpha v integrin is a critical switch involved in turning on the myofibroblast cells to make scar tissue.

The team studied specially bred mice with fibrosis to see if removing the alpha v integrin molecule on myofibroblasts would reduce the amount of scar tissue in their organs.

Researchers found that when they removed alpha v integrin from these cells, the mice were protected from fibrosis of the liver, lung and kidneys.

They also found that when they treated the mice with a new experimental drug designed to block alpha v integrins, the animals were protected from liver and lung fibrosis.

Dr Neil Henderson, a Wellcome Trust clinical scientist and consultant hepatologist at the University of Edinburgh / MRC Centre for Inflammation Research, said: "When tissue scarring becomes severe, affected organs do not work properly and currently the only treatment for end-stage organ failure is transplantation. However the shortage of donor organs means that many patients die while waiting for surgery.

"Therefore, the development of new therapies to treat fibrosis and reduce the need for organ transplantation would potentially be a major step forward in the treatment of patients with these devastating diseases."


'/>"/>

Contact: Eleanor Cowie
eleanor.cowie@ed.ac.uk
44-131-650-6382
University of Edinburgh
Source:Eurekalert

Page: 1

Related medicine news :

1. Discovery could help to develop drugs for organ transplant and cancer patients
2. Xenotransplantation as a therapy for type 1 diabetes
3. First, Second Kidney Transplants Have Similar Success: Study
4. Lenalidomide prolongs disease control for multiple myeloma patients after stem cell transplant
5. Statins prevent cancer in heart transplant recipients
6. U.S. Liver Transplants Declining
7. Study shows antibiotic improves respiratory function in lung transplant patients
8. UCLA launches first face transplantation program in western US
9. Use of Smokers Lungs for Transplant Has Pros, Cons
10. Skin transplant offers new hope for vitiligo patients
11. Haematopoietic stem cell transplantation increases survival in systemic sclerosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2019)... SARASOTA, Fla. (PRWEB) , ... September 17, 2019 ... ... plans and Dental Service Organizations (DSOs) has earned Michael Cole, Vice President of ... presented today by the National Association of Dental Plans (NADP) at their annual ...
(Date:9/17/2019)... , ... September 17, 2019 , ... ... join the largest accountable care organization (ACO) in the country, the company announced ... groundbreaking collaboration to improve care quality and increase cost efficiency. This opportunity is ...
(Date:9/17/2019)... ... September 17, 2019 , ... Genomenon ... , with the goal of providing resources to assist researchers and encourage pharmaceutical ... progressive disease causing abnormal iron deposits in the brain. , BPAN Warriors ...
(Date:9/14/2019)... Okla. (PRWEB) , ... September 14, 2019 , ... ... cannabis industry, has time and again tried to bring the most relevant and important ... ray of hope on an increasingly large number of people across the world suffering ...
(Date:9/11/2019)... ... September 11, 2019 , ... Global Education Group (Global), ... (CME) provider, is the official accreditor for PAINWeek, the largest US pain conference ... topics, as it has done for the past ten years. In addition, the ...
Breaking Medicine News(10 mins):
(Date:9/12/2019)... ... September 12, 2019 , ... ... , revenue cycle management services, integrated practice management, and patient engagement solutions, ... Sponsor at National User Conference (NUCON) 2019 . The annual conference ...
(Date:9/11/2019)... ... September 12, 2019 , ... ... Best Practices, An FDAnews Webinar, Thursday, Sept. 26, 2019, 1:30-3:00 p.m. EDT, ... (DSCSA) implementation requirements? Is the company clear on nuances of the guidelines regulating ...
(Date:9/11/2019)... ... September 11, 2019 , ... Radiology… gastroenterology… ophthalmology… pathology… , ... evaluate medical images. In fact, image analysis software represents one of the fastest-growing ... to AI-based image analysis, one will be left behind. , As both a ...
Breaking Medicine Technology: