Navigation Links
Hope for transplant patients as study finds key to organ scarring
Date:11/10/2013

Patients with damaged organs could be helped by new treatments after scientists have discovered how tissues scar.

Researchers say that the finding could pave the way for new drugs and eventually reduce the number of patients on organ transplant waiting lists.

Fibrotic diseases occur in many tissues within the body including the liver, lung or kidneys and have a range of causes including viruses or toxins. Experts say that the main source of scar tissue is found in specialised cells called Myofibroblasts.

The study discovered that a molecule on these cells is a key regulator of fibrotic disease.

Scientists say that the molecule called alpha v integrin is a critical switch involved in turning on the myofibroblast cells to make scar tissue.

The team studied specially bred mice with fibrosis to see if removing the alpha v integrin molecule on myofibroblasts would reduce the amount of scar tissue in their organs.

Researchers found that when they removed alpha v integrin from these cells, the mice were protected from fibrosis of the liver, lung and kidneys.

They also found that when they treated the mice with a new experimental drug designed to block alpha v integrins, the animals were protected from liver and lung fibrosis.

Dr Neil Henderson, a Wellcome Trust clinical scientist and consultant hepatologist at the University of Edinburgh / MRC Centre for Inflammation Research, said: "When tissue scarring becomes severe, affected organs do not work properly and currently the only treatment for end-stage organ failure is transplantation. However the shortage of donor organs means that many patients die while waiting for surgery.

"Therefore, the development of new therapies to treat fibrosis and reduce the need for organ transplantation would potentially be a major step forward in the treatment of patients with these devastating diseases."


'/>"/>

Contact: Eleanor Cowie
eleanor.cowie@ed.ac.uk
44-131-650-6382
University of Edinburgh
Source:Eurekalert

Page: 1

Related medicine news :

1. Discovery could help to develop drugs for organ transplant and cancer patients
2. Xenotransplantation as a therapy for type 1 diabetes
3. First, Second Kidney Transplants Have Similar Success: Study
4. Lenalidomide prolongs disease control for multiple myeloma patients after stem cell transplant
5. Statins prevent cancer in heart transplant recipients
6. U.S. Liver Transplants Declining
7. Study shows antibiotic improves respiratory function in lung transplant patients
8. UCLA launches first face transplantation program in western US
9. Use of Smokers Lungs for Transplant Has Pros, Cons
10. Skin transplant offers new hope for vitiligo patients
11. Haematopoietic stem cell transplantation increases survival in systemic sclerosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/19/2019)... ... November 19, 2019 , ... BW Health Group and ... provide joint clients with more effective and efficient service. , Under the Collaboration Agreement, ... its preferred medical communications partner on projects not within its own scope of services. ...
(Date:11/19/2019)... ... November 18, 2019 , ... ... the scientific and healthcare industries, announced today the asset acquisition of Laboratory ... as Advantage Business Media) ceased operations after 13 years in June 2019. ...
(Date:11/19/2019)... ... November 19, 2019 , ... iPatientCare, a pioneer in ... solutions, announces Virtual User Conference (VUCON), which will highlight the impact of patient ... experience. , VUCON sessions are designed to demonstrate the new ...
(Date:11/16/2019)... ... November 15, 2019 , ... ... impairment, has announced the Best Memory Care Facilities in Medford, Oregon. The guide ... and amenities. , According to the Alzheimer’s Association , 5.6 million ...
(Date:11/16/2019)... ... November 15, 2019 , ... As demand ... access to cannabis via well-managed dispensaries becomes more and more important, both for ... online provider of state-of-the-art, online, custom cannabis business plans is now increasing its ...
Breaking Medicine News(10 mins):
(Date:11/19/2019)... Wis. (PRWEB) , ... November 18, 2019 , ... ... on Various Health Biomarkers Using Cell-Based Assays” by Elizabeth Patric has been named ... categories including Holistic Medicine, Biochemistry, Microbiology, Nosology, Nursing Reference, Research and Theory, and ...
(Date:11/19/2019)... MIAMI (PRWEB) , ... November 19, 2019 , ... ... the host of the educational television program “Behind The Scenes” with Laurence Fishburne. ... have an impact on today’s society. In an imminent episode to be aired ...
(Date:11/16/2019)... ... 2019 , ... MemoryCare.com , a comprehensive resource for ... Care Facilities in Columbus, Ohio. The guide identifies 21 memory care communities based ... the Alzheimer’s Association , 5.6 million people age 65 and older are ...
Breaking Medicine Technology: