Navigation Links
Hope for stroke victims
Date:2/8/2011

Much of the devastation of stroke and head trauma is due to damage caused the overproduction of a substance in the brain called glutamate. Preventing this damage has been impossible, until now, as many drugs don't cross the so-called blood-brain barrier, and those that do often don't work as intended. But a method originally devised at the Weizmann Institute of Science may, in the future, offer a way to avert such glutamate-induced harm.

Prof. Vivian I. Teichberg of the Institute's Neurobiology Department first demonstrated a possible way around these problems in 2003. Glutamate a short-lived neurotransmitter is normally all but absent in brain fluids. After a stroke or injury, however, the glutamate levels in brain fluid become a flood that over-excites the cells in its path and kills them. Instead of attempting to get drugs into the brain, Teichberg had the idea that one might be able to transport glutamate from the brain to the blood using the tiny "pumps," or transporters, on the capillaries that work on differences in glutamate concentration between the two sides. Decreasing glutamate levels in blood would create a stronger impetus to pump the substance out of the brain. He thought that a naturally-occurring enzyme called glutamate-oxaloacetate transaminase (GOT, for short) could "scavenge" blood glutamate, significantly lowering its levels. By 2007, Teichberg and his colleagues had provided clear evidence of the very strong brain neuroprotection that oxolacetate (a chemical similar to GOT) afforded rats exposed to a head trauma.

Two new studies conducted by Fransisco Campos and others from the lab of Prof. Jose Castillo in theUniversity of Santiago de Compostela, Spain now provide a definitive demonstration of Teichberg's results. In the first, the scientists conclusively showed that oxoloacetate injected into rats with stroke-like brain injuries reduces glutamate levels both in the blood and in the affected brain region, while
'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dark Chocolate May Lower Stroke Risk
2. Can Chocolate Lower Your Risk of Stroke?
3. New American Heart Association Survey Finds Heart Disease and Stroke Patients Face Significant Barriers in Obtaining Quality, Affordable Care
4. Low levels of natural antibodies behind stroke
5. Chocolate lovers could be lowering their risk of stroke: Study
6. Connecticut Board Considers Warning About Risk Of Stroke Following Chiropractic Neck Manipulation
7. After a Stroke, High Risk for a Recurrence
8. New edition of landmark stroke textbook
9. Farmers markets offer different strokes for different folks
10. New Successful Treatment Improves Walking Post Stroke
11. Patients Do Better at Hospitals That Follow Stroke Guidelines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... 2015 On April 14th, 2015, Symantec released ... which they say, “exposes a tactical shift by cyberattackers.” With ... were introduced in 2014 - almost a million a day ... to be identified and patched by prominent manufacturers – as ... doing business in a digital world can be fraught with ...
(Date:4/18/2015)... 18, 2015 “ ArcAngel ” was featured ... a look at the latest and coolest applications ... the host of AppWatch and technology expert, conducted the app ... safety app. , In a turbulent world, people may ... 911 should always be their first move, but some situations ...
(Date:4/18/2015)... 18, 2015 French physician and gastronome ... choices when he uttered, “Tell me what you eat, ... food to cope with stress or sadness has often ... indicates otherwise. Data collected from their Emotional ... to emotional eating, but for different reasons. , Collecting ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 John Evans, ... Party on the Patio from 2 p.m. to 3 ... located at 1320 Executive Ct. in Pekin, Illinois, serves ... who need some help to maintain their independence. , ... and tropical treats will be served during the luau. ...
(Date:4/17/2015)... April 17, 2015 ERGO-Pedic Products, LLC, ... introducing two new products to help a broader range ... pain relief are the second most common visitors to ... product, designed specifically to help relieve sitting pain. Then, ... and thousands of happy customers later, we began getting ...
Breaking Medicine News(10 mins):Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:A Personal Safety Application was Featured on NewsWatch Television 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6Health News:John Evans Supportive Living Community Prepares for Party on the Patio 2Health News:Seat Cushion Company Credits Customer Driven Design For Two New Products 2
... Reuters, the,world,s leading source of intelligent information for ... Pharma KOLexperts, a,new solution designed to help pharmaceutical ... opinion leaders,(KOLs) and scientific experts. It is the ... to rank life sciences KOLs with a range ...
... Oct. 14 Katherine O. McCary, of,Midlothian, Virginia, ... serve as,a member of the National Council on ... Ms. McCary,s nomination on October 2, 2008., ... Banks, Inc. and reports to,the Chairman, President and ...
... DC OCTOBER 14, 2008 Late-breaking ... Prevent Radio Contrast Nephropathy in Patients Undergoing ... during the 20th annual Transcatheter Cardiovascular Therapeutics ... Research Foundation (CRF). , The prospective, ...
... digestive illnesses should have levels monitored, study says , , ... bowel disease or chronic liver disease may be at ... says. , Vitamin D is essential in the body,s ... role in a person having strong, healthy bones. , ...
... ... DIEGO, Oct. 14 The American Council on Exercise,(ACE), America,s ... education and training organizations in the world,today announced key findings ... Crosse through its exercise and health program,on the benefits of ...
... Pharmaceuticals, LLC, a,privately held, specialty pharmaceutical company ... today announced that it has,acquired North American ... from Crown Laboratories, Inc. This agreement expands ... chronic dermatologic,conditions including scalp psoriasis and seborrheic ...
Cached Medicine News:Health News:Thomson Reuters Launches Thomson Pharma KOLexperts(R) to Help the Pharmaceutical Industry Objectively Identify, Verify and Rank Scientific Experts, Product Advocates, Clinical Investigators and Key Opinion Leaders 2Health News:Midlothian Resident Katherine McCary Appointed by President Bush to National Council on Disability 2Health News:Late-breaking results of clinical trial on therapeutic endovascular cooling reported at TCT 2008 2Health News:IBD, Liver Disease Patients Show Vitamin D Deficits 2Health News:American Council on Exercise (ACE) Studies Impact of Boot Camp-Style Workouts 2Health News:Avidas Pharmaceuticals Signs Agreement to Acquire North American Rights to Products That Address Chronic Dermatologic Conditions 2
(Date:4/17/2015)... ADELAIDE, Australia , April 17, 2015 ... the discovery and development of innovative therapeutics for the ... system, today announced the presentation of data from three ... American Association for Cancer Research (AACR) 106 th ... Philadelphia, PA USA. ...
(Date:4/16/2015)... , April 16, 2015  Hologic, Inc. ... cervical cancer screening study i published on-line ... peer-reviewed journal of the American Cancer Society. ... and the University of Pittsburgh Medical Center, supports current consensus ... recommend that women 30-65 years of age be ...
(Date:4/16/2015)... , April 16, 2015  Diplomat Pharmacy, Inc. ... Shannon Beltrand to their senior leadership team as ... be responsible for securing and properly monitoring Diplomat,s data, ... both internally and externally. Additionally, she will play key ... "We are very excited to have someone ...
Breaking Medicine Technology:Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Diplomat Names Shannon M. Beltrand as New CISO 2
... Calif., Oct. 17, 2011 Abaxis, Inc. (NasdaqGS: ABAX), a ... a conference call to discuss its financial results for the ... The call will be at 4:15 p.m. ET on Tuesday, ... the second quarter of fiscal year 2012 after the market ...
... YORK, Oct. 17, 2011 Reportlinker.com announces ... available in its catalogue: ... http://www.reportlinker.com/p0487169/Novo-Nordisk-A/S-PharmaVitae-Profile.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory ... the historical and forecast performance for Novo ...
Cached Medicine Technology:Abaxis to Report Second Quarter Fiscal Year 2012 Financial Results Tuesday, October 25, 2011 2Novo Nordisk A/S: PharmaVitae Profile 2
... Medpor Midface Rim is designed ... concavities of the midface, including ... malar. When positioned in the ... Medpor Midface Rim implant aids ...
... Rim Implants provide the surgeon ... augmentation of the inferior and ... or secondary rim repair. The ... projection and extends around the ...
The new Inferior Medial Orbital Rim Implant (IMORI) provides surgeons with an excellent alternative for patients with a deficient or recessed "tear trough" area often characterized as a look of fatig...
Flattened points in vertical plane, straight shafts, cross action, round handle....
Medicine Products: