Navigation Links
Hope for patients with HIV-associated cognitive impairment
Date:8/14/2012

Current drug therapy for patients with HIV is unable to control the complete replication of the virus in the brain. The drugs therefore do not have any effect against the complications associated with neurocognitive impairment in patients with HIV. New research by Joseph Steiner and colleagues from Johns Hopkins University has discovered that a group of plant polyphenols known as catechins, which naturally occur in green tea and the seed of the cacao tree, may help in the prevention of these neurological complications. Their work is published online in Springer's Journal of NeuroVirology.

Previous research has established the critical role of a protein called brain-derived neurotrophic factor (BDNF) in supporting the survival and growth of neurons in the brain. This protein is active in areas of the brain vital to learning, memory and higher thinking. Patients with HIV have been found to have lower levels of BDNF in their brains than healthy individuals suggesting that this could be directly responsible for the cognitive impairment suffered.

In their research, Steiner and colleagues analysed the effects of 2000 compounds, containing both natural substances and FDA-approved drugs, on brain cells in the laboratory. They identified a series of compounds which had the potential to help protect neurons in the brain. Nine of these were related to epicatechin, which is found in cocoa and green tea leaves. Further screening and comparison with resveratrol, the antioxidant found in red wine, specifically identified epicatechin and epigallocatechin gallate (EGCG) as being the most effective at helping protect neurons by inducing production of BDNF.

Although the antioxidant activities of epicatechin and EGCG are well documented, the discovery that they could be responsible for inducing production of BDNF is an exciting advancement in this area. The fact that these compounds readily cross the blood-brain barrier further increases their therapeutic potential, as this is often a major stumbling block in the development of therapies directed at the brain. This provides hope for patients with HIV as there is currently no neuroprotective therapy available for patients with HIV-associated cognitive impairment.

The authors conclude: "Due to its simpler structure and more efficient blood-brain barrier penetration properties, epicatechin might be the best therapeutic candidate for neurodegenerative diseases. These include HIV-associated cognitive disorders where oxidative stress is an important pathophysiological mechanism." Further research in patients with HIV is required to elucidate just how effective these naturally occurring compounds could be.


'/>"/>

Contact: Renate Bayaz
renate.bayaz@springer.com
49-622-148-78531
Springer
Source:Eurekalert

Related medicine news :

1. Study Questions Guidelines on Radiation for Older Breast Cancer Patients
2. Study: Majority of older, early-stage breast cancer patients benefit from radiation after lumpectomy
3. Individualized care best for lymphedema patients, MU researcher says
4. Rhode Island Hospital study: Bariatric patients with obstructive sleep apnea fail to show symptoms
5. Patients Often Kept in Dark About Off-Label Drug Use: Study
6. Underinsured Heart Disease Patients Die Sooner, Study Finds
7. Doctors often dont disclose all possible risks to patients before treatment
8. Patients want more risks disclosed before treatment
9. No difference in death rates among patients exposed to common rheumatoid arthritis drugs
10. Weekends More Fatal for Older Patients With Head Injury: Study
11. Coach could be key in helping stroke patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... March 29, 2017 , ... Wells Pharmacy Network, a proud ... the upcoming World Congress, in Hollywood Florida April 6-8, 2017. , Ben David, ... visionary leader in the training of physicians, scientists, and members of the public ...
(Date:3/29/2017)... OK (PRWEB) , ... March 29, 2017 , ... ... now receive FASTBRACES® in Carnegie, OK, from Dr. Jamie Cameron, with ... straighten teeth efficiently, compared to traditional orthodontic treatment. Depending on each patient’s case, ...
(Date:3/29/2017)... ... March 29, 2017 , ... Altima ... and diagramming network and data center assets and audio-video devices has recently updated ... new equipment shapes for free and download shapes and stencils from http://www.VisioStencils.com. ...
(Date:3/29/2017)... ... March 29, 2017 , ... The assembly ... assembly protocols involve many repetitive steps and often scientists require many different versions ... high-throughput needed, and results in a lower error rate and cost saving for ...
(Date:3/29/2017)... ... March 29, 2017 , ... Physicians’ Education Resource® ... continuing medical education conference for clinicians who manage some of the most difficult-to-treat ... , The program will be led by co- chairs Dr. John Marshall, ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017  The leader in accelerated orthodontics, OrthoAccel ® ... Daher , Manal Ibrahim , Kenji Ojima ... be the featured microlecture presenters at the AcceleDent ® ... Orthodontists (AAO) Annual Session, April 21-25, 2017. Orthodontists and ... daily at 11:20 a.m. On the opening morning of ...
(Date:3/29/2017)... , March 29, 2017  Glenmark Pharmaceuticals, ... for GSP 301, an investigational fixed-dose combination of ... mcg) administered twice-daily as a nasal spray being ... These results are from a recently completed Phase ... GSP 301 combination therapy versus mometasone, olopatadine or ...
(Date:3/29/2017)... 29, 2017 Transparency Market ... provides an exhaustive study of the U.S. substance abuse ... companies are functional in this market at present, ... leading companies, such as GlaxoSmithKline Plc., Pfizer Inc., ... on various marketing strategies to increase their visibility, ...
Breaking Medicine Technology: