Navigation Links
Homogeneous tuberculosis treatment ineffective in children, UT Southwestern researchers find
Date:2/10/2011

he study, the researchers virtually simulated clinical trials involving 10,000 patients who are 10 years old or younger. The computer simulation factored in pharmacokinetics (how a body handles a drug based on heterogeneous factors) to determine how likely a dose of a given drug is to kill TB. The children were grouped into three groups: fast acetylators, meaning their bodies metabolize the drugs quickly; children ages 1 to 10 who are slow acetylators; and infants who are slow acetylators.

Dr. Gumbo's team found that the drug concentrations typically used to treat children with TB are too low and that children respond differently to the standardized medication depending partly on their age and how quickly their bodies metabolize the drug.

"Despite the desire for standardized therapy, our findings support the long-held notion that there is no 'average' or 'standard' child. It is safe to assume that with 2.2 billion children worldwide, there will be 2.2 billion different regimens needed to effectively treat tuberculosis," Dr. Gumbo said.

He said the importance of the findings is that they can be applied to many other infections, including methicillin-resistant-Staphylococcus aureus, or MRSA.

"This is the future, even for adults," Dr. Gumbo said. "Being able to individualize what drug someone gets and what dose this is the future of medicine."

Dr. Gumbo's research is funded by a 2007 NIH Director's New Innovator Award, which supports bold ideas from some of the nation's most innovative early-career scientists.

Dr. Jotam Pasipanodya, research scientist in internal medicine at UT Southwestern, and researchers from the University of KwaZulu-Natal, the Howard Hughes Medical Institute, and the Kwa-Zulu Natal Research Institute for Tuberculosis and HIV in South Africa also contributed to the study.


'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Older people and those with HIV are more vulnerable to tuberculosis
2. UN Foundation President Timothy E. Wirth Commends African Leaders for Renewed Commitment to the Global Fund to Fight AIDS, Tuberculosis and Malaria
3. Major funding awarded to improve treatment of drug-resistant tuberculosis and HIV co-infection
4. A breakthrough in tuberculosis research
5. A*STAR and Institut Merieux/bioMerieux invest S$3m ($2.2m) in tuberculosis research
6. New genomic marker for tuberculosis may help identify patients who will develop the disease
7. New dual recognition mechanism discovered in tuberculosis
8. Einstein scientist awarded $4 million to develop genetic strategy to combat tuberculosis
9. Study finds evidence of increased lung cancer risk among tuberculosis patients
10. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
11. Women More Likely to Fail Treatment for Atrial Fibrillation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Garth Brooks Chicago tickets go on sale Friday, ... Garth Brooks was one of the leaders on the country ... 1989. Since "Much Too Young (To Feel This Damn Old)" was ... Okl. native and in the years that he has been away ... stage and in the recording studio. Between 2001 and 2009, fans ...
(Date:7/25/2014)... 25, 2014 -- The Elizabeth Glaser Pediatric AIDS ... the Medicines Patent Pool (MPP) and Gilead Sciences, ... (TAF), a promising new HIV medication. The agreement ... (AIDS 2014) in Melbourne, Australia. , While ... early data suggests it could be a key ...
(Date:7/25/2014)... A report released by the Juvenile Diabetes ... 2013 (July 1, 2012- June 30, 2013). , Outside of ... is the largest single funder of type 1 diabetes research ... with most of the top research centers. There is ... 1 diabetes in the near future. , Since the 2008 ...
(Date:7/25/2014)... Mateo, CA (PRWEB) July 25, 2014 ... an upcoming episode of Innovations with Ed Begley Jr, ... and show times TBA. , For more than four ... the Bay Area community through its residential alcohol and ... will educate on Project Ninety's humble idea and how ...
(Date:7/25/2014)... 2014 Stwd.co.uk, one of the leading ... of cheap evening dress for women. In ... big promotion for these items. They are available at ... last until August 30. , “We are pleased to ... outfits, we have a large number of stylish special ...
Breaking Medicine News(10 mins):Health News:Garth Brooks Chicago Tickets for Performance at Allstate Arena in Rosemont Go On Sale July 25th 2Health News:Garth Brooks Chicago Tickets for Performance at Allstate Arena in Rosemont Go On Sale July 25th 3Health News:Report: JDRF 2013 Annual Research Spending Down by $50 million 2Health News:Project Ninety to be Featured on Innovations with Ed Begley, Jr. 2Health News:Project Ninety to be Featured on Innovations with Ed Begley, Jr. 3Health News:Famous Supplier Stwd.co.uk Announces Its New Selection of Evening Dresses for Women 2
... The number of airline mishaps attributed to pilot error ... analysis conducted by researchers at the Johns Hopkins Bloomberg ... airline mishaps remained stable during that time, the proportion ... rate of mishaps related to a pilots poor decision-making ...
... New Advice for Doctors About Low-Fat, Low-Carb Restricted ... 28 The American,Diabetes Association (ADA) today issued ... providers treat people with diabetes,using the most current ... occurs in the Medical Nutrition Therapy,section dealing with ...
... deprive them of rest needed for healing, study says ... patterns of intensive care unit (ICU) patients are so ... restorative phases of sleep that help promote healing, says ... Southwestern Medical Center at Dallas. , The study ...
... Eclipsys Corporation(R),(Nasdaq: ECLP ), The Outcomes ... 2008 JPMorgan Healthcare Conference taking place from,January 7th ... http://www.newscom.com/cgi-bin/prnh/20050209/FLW006LOGO ), Eclipsys executives will ... 3:00 p.m. Pacific time. To access the live ...
... The National Drug,Intelligence Center (NDIC), a ... nation,s principal center for strategic drug intelligence, ... This strategic,assessment presents an analysis of key ... and abuse in the,United States. The assessment ...
... SAN FRANCISCO, Dec. 27 OneMedPlace will hold its ... the Sir Francis Drake,Hotel in Union Square., This ... cap public,companies and early stage venture backed companies to ... both public and private, will present at,the conference and ...
Cached Medicine News:Health News:Pilot error declines as factor in airline mishaps 2Health News:ADA Issues New Clinical Practice Recommendations 2Health News:ADA Issues New Clinical Practice Recommendations 3Health News:ICU Patients Not Getting Enough Sleep 2Health News:Eclipsys to Present at JPMorgan Healthcare Conference 2Health News:Eclipsys to Present at JPMorgan Healthcare Conference 3Health News:National Drug Intelligence Center Releases 2008 National Methamphetamine Threat Assessment 2Health News:OneMedPlace Emerging Healthcare Technologies Finance Forum Jan 7, 8th 2
(Date:7/25/2014)... BERWYN, Pa. , July 25, 2014  AMETEK, ... appointment of Kurtis L. Goos as Vice ... Engineered Materials, Interconnects and Packaging (EMIP) Division. ... has extensive general management and business development experience, especially ... to make important contributions to the continued growth and ...
(Date:7/25/2014)... NORTH CHICAGO, Ill., July 25, 2014 ... PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION ... RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION AbbVie (NYSE: ... quarter ended June 30, 2014. "This was ... and earnings per share above our original guidance and announced ...
(Date:7/24/2014)... , July 24, 2014   AcelRx Pharmaceuticals, Inc. ... focused on the development and commercialization of innovative therapies ... confirmed the PDUFA date for Zalviso remains July 27, ... rumor circulated online stating the Food and Drug Administration ... there has been no notification to the company from ...
Breaking Medicine Technology:AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2AbbVie Reports Second-Quarter 2014 Financial Results 2AbbVie Reports Second-Quarter 2014 Financial Results 3AbbVie Reports Second-Quarter 2014 Financial Results 4AbbVie Reports Second-Quarter 2014 Financial Results 5AbbVie Reports Second-Quarter 2014 Financial Results 6AbbVie Reports Second-Quarter 2014 Financial Results 7AbbVie Reports Second-Quarter 2014 Financial Results 8AbbVie Reports Second-Quarter 2014 Financial Results 9AbbVie Reports Second-Quarter 2014 Financial Results 10AbbVie Reports Second-Quarter 2014 Financial Results 11AbbVie Reports Second-Quarter 2014 Financial Results 12AbbVie Reports Second-Quarter 2014 Financial Results 13AbbVie Reports Second-Quarter 2014 Financial Results 14AbbVie Reports Second-Quarter 2014 Financial Results 15AbbVie Reports Second-Quarter 2014 Financial Results 16AbbVie Reports Second-Quarter 2014 Financial Results 17AbbVie Reports Second-Quarter 2014 Financial Results 18AbbVie Reports Second-Quarter 2014 Financial Results 19AbbVie Reports Second-Quarter 2014 Financial Results 20AbbVie Reports Second-Quarter 2014 Financial Results 21AbbVie Reports Second-Quarter 2014 Financial Results 22AbbVie Reports Second-Quarter 2014 Financial Results 23AbbVie Reports Second-Quarter 2014 Financial Results 24AbbVie Reports Second-Quarter 2014 Financial Results 25AbbVie Reports Second-Quarter 2014 Financial Results 26AbbVie Reports Second-Quarter 2014 Financial Results 27AbbVie Reports Second-Quarter 2014 Financial Results 28AbbVie Reports Second-Quarter 2014 Financial Results 29AbbVie Reports Second-Quarter 2014 Financial Results 30AbbVie Reports Second-Quarter 2014 Financial Results 31AbbVie Reports Second-Quarter 2014 Financial Results 32AbbVie Reports Second-Quarter 2014 Financial Results 33AbbVie Reports Second-Quarter 2014 Financial Results 34AbbVie Reports Second-Quarter 2014 Financial Results 35
... 5, 2011 meridianEMR, the market leader in EHR ... Somerville, New Jersey was the first meridianEMR customer to ... Centers for Medicare and Medicaid Services (CMS). On July ... $54,000 for three physicians via direct deposit. The group ...
... Biotech Ltd. (Nasdaq: SVA ), a leading ... of Jacob Chik Keung Ho, its Chief Financial Officer, for ... a new Chief Financial Officer to replace Mr. Ho, who ... 2011.  Ms. Nan Wang, Vice President of Sinovac, has been ...
Cached Medicine Technology:meridianEMR® Customers Start Receiving Meaningful Use Incentive Payments 2meridianEMR® Customers Start Receiving Meaningful Use Incentive Payments 3Sinovac Announces Management Changes 2Sinovac Announces Management Changes 3
... non-adhesive sealing method maintains the ... (HALS) procedures, allowing the surgeon ... throughout. Because HALS requires incisions ... patients experience less trauma compared ...
... series offers a range of standard, ... design delivers therapy to meet the ... results in commercial and clinical effectiveness ... in the SleepStyle 200 series is ...
... The SleepStyle 200 series offers ... integrated CPAP models. The design delivers ... patients. Performance features promote results in ... care. The strongest differentiator in the ...
... series offers a range of standard, ... design delivers therapy to meet the ... results in commercial and clinical effectiveness ... in the SleepStyle 200 series is ...
Medicine Products: