Navigation Links
Hodgkin lymphoma survivors have increased risk of stroke and transient ischemic attack
Date:6/17/2009

Patients treated for Hodgkin lymphoma with radiation therapy have a substantially higher risk of stroke, according to a new study published June 17 online in the Journal of the National Cancer Institute.

The study was undertaken because information on clinically verified stroke and transient ischemic attack (TIA), or a "mini stroke," following Hodgkin lymphoma is limited.

In order to quantify the long-term risks, Flora E. van Leeuwen, Ph.D., of the Department of Epidemiology at the Netherlands Cancer Institute in Amsterdam, and colleagues performed a retrospective cohort study among 2,201 Hodgkin lymphoma survivors. The patients, who had survived at least 5 years from the time of diagnosis, had been treated between 1965 and 1995 before age 51. The researchers compared incidence rates of clinically verified stroke and TIA in this cohort with rates in the general population.

After a median follow-up of almost 18 years, 96 patients developed cerebrovascular disease. The incidence rate for stroke was 2.2 times the incidence in the general population. For TIA, it was 3.1. Risks also remained elevated, compared to those in the general population, after prolonged follow-up. Radiation to the neck and mediastinum was associated with increased risk, whereas chemotherapy was not.

"For young survivors of Hodgkin lymphoma, who are at especially increased risk of stroke and TIA, physicians should consider appropriate risk-reducing strategies, such as treatment of hypertension and lifestyle changes to reduce the risk of stroke and TIA," the authors write.

In an accompanying editorial, Dan L. Longo, M.D., of the National Institute on Aging, part of the National Institutes of Health in Bethesda, Md., discusses the study's contribution to the "already overwhelming evidence that radiation therapy in Hodgkin's disease is short-sighted" He applauds the detailed medical documentation and nearly complete follow-up of the patients in the study, but notes a weakness, in that the relationship of stroke to radiation doses was not examined.

According to Longo, results of this study should affect a physician's choice of primary treatment. "Unfortunately, given the life-long increased risks of late effects that have been documented from the use of radiation therapy, we simply cannot keep exposing patients to risk without clear benefit while we wait for safety data to be produced," he writes. "With an alternative therapy at hand that is just as effective, it is simply unjustified to keep using a toxic modality for the next 10-20 years"


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Radiation May Raise Stroke Risk After Hodgkins
2. Pixantrone Overview in Non-Hodgkins Lymphoma to be Presented at 2009 Pan Pacific Lymphoma Conference
3. Medarex Announces Clinical Data for MDX-1401 in Hodgkins Lymphoma at Annual Meeting of the American Association for Cancer Research
4. New NCCN Guidelines for Primary Cutaneous B-Cell Lymphoma and Updates to NCCN Guidelines for Non-Hodgkins Lymphomas
5. DNA Variations May Alter Risk of Hodgkins Disease
6. DNA differences may influence risk of Hodgkin disease
7. Hodgkins Survivors Prone to Breast Cancer Later
8. Pediatric Hodgkins disease survivors face increased breast cancer risk
9. Three Italian Multicenter Studies Report High (>70%) Rates of Complete Remission (CR) Utilizing Zevalin Radio-Immunotherapy (RIT) in Treatment of Newly Diagnosed or Relapsed or Refractory Non-Hodgkins Lymphoma
10. Video: Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkins Lymphoma
11. Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkins Lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... As health professionals ... known as “patient engagement.” The patient is doing more than filling out a survey; ... , “There is an increasing emphasis in health care and research on the importance ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... PurhealthRX ... CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will ... and providing a CBD form that can be easily incorporated into liquid products, while ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017  AllianceRx Walgreens Prime, the combined central ... and pharmacy benefit manager Prime Therapeutics LLC (Prime), today ... included the unveiling of new signage at its headquarters ... as at a few other company-owned facilities across the ... patients, some of whom will begin to see the ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
Breaking Medicine Technology: