Navigation Links
Hodgkin Lymphoma Kids Face Greater Risk of Future Problems
Date:5/31/2008

Breast cancer leading cause of death for female survivors; cardiovascular events for males

SATURDAY, May 31 (HealthDay News) -- People who survived Hodgkin lymphoma as children have an increased risk of developing and dying from another cancer or cardiovascular disease as adults, according to a new report.

The treatment for Hodgkin -- chemotherapy and radiation -- may help drive these increased risks, according to the researchers.

"The bottom-line message is that a portion of those who survive Hodgkin lymphoma continue to have significant health needs beyond their five-year 'cure' mark," Dr. Sharon Castellino, an assistant professor of pediatrics at Brenner Children's Hospital, part of Wake Forest Baptist Medical Center, said in a prepared statement. "Survivors and their doctors need to be aware of continued risks in adulthood from treatment received more than 20 years ago."

The study, primarily by Wake Forest researchers, was scheduled to be presented May 31 at the annual meeting of the American Society of Clinical Oncology, in Chicago.

Hodgkin lymphoma follows the growth of malignant cells in the lymph system, which is part of the immune system. The disease is considered one of the more curable types of cancer, with 90 percent of patients surviving in the first five years of treatment.

The study followed 1,927 of these five-year Hodgkin survivors who were diagnosed between 1970 and 1986 at a median age of 14 years. Of that group, 320 people died: 30 percent from a recurrence of Hodgkin, 26 percent from a different cancer, and 19 percent from a cardiovascular event such as a heart attack or stroke.

The findings linked an increased risk of premature death in the male survivors to higher doses of chemotherapy, including anthracycline drugs. Among females, radiation therapy -- regardless of dosage -- was associated with the higher death rate.

"It hadn't been clarified until this study that there was a different pattern of risks in men and women," Castellino, a pediatric oncologist, said. "Other than a recurrence of the original cancer, the leading cause of death in women is breast cancer, and for men it is cardiovascular events."

New prevention recommendations, such as earlier health screenings, could result from the findings. "Currently, women who received treatment for the disease are advised to have mammograms as early as 25 years old," she said. "But, currently there are no specific guidelines for heart disease prevention over those for the general population."

Although radiation therapy doses given to children with Hodgkin's have been lowered since the 1980s and techniques have been refined, Castellino said the heart and other critical structures are often exposed to radiation. Hodgkin's often attacks the lymph system in the chest, so radiation usually targets the neck and upper chest area.

More information

The American Cancer Society has more about Hodgkin lymphoma.



-- Kevin McKeever



SOURCE: Wake Forest University Baptist Medical Center, news release, May 31, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Doctors Report High Survival Rates for Hodgkins Disease
2. Micromet and MedImmune to Present New Clinical Data for Anti-CD19 BiTE(R) Antibody at American Society of Hematology Annual Meeting Showing Objective Clinical Responses in Relapsed Non-Hodgkins Lymphoma Patients
3. Outlook improves for patients with non-Hodgkin lymphoma over past decade
4. Outcomes Improve for Non-Hodgkin Lymphoma Patients
5. USC researchers find new clues to risk of Hodgkin lymphoma
6. The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia
7. The Leukemia & Lymphoma Society Provides Patients with the Latest Information on Myeloma
8. Cell Therapeutics, Inc. (CTI) Plans to Submit Supplemental Biologics License Application (sBLA) for ZEVALIN(R) Consolidation of First Remission in Advanced Stage Follicular Lymphoma in 2008
9. January 1 Looms Large for Lymphoma Patients
10. Possible Cure for Rare Lymphoma Reported
11. Pharmion and Methylgene Report Favorable Results for Phase 2 MGCD0103 Single- Agent Studies in Relapsed or Refractory Lymphomas at the 49th American Society of Hematology (ASH) Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... A lot has been reported about the fitness ... access to health and wellness resources most Americans could ever dream of having at ... a schedule as frenetic as the U.S. President. , In honor of President’s ...
(Date:2/12/2016)... ... ... The Central Coast Autism Spectrum Center (CCASC) invites teens ages 11-18 to its annual Winter ... teens with and without special needs to gather in a safe and supportive environment. Volunteers ... will take place on Saturday, Feb. 13 from 7 to 9:30 p.m. at Elks Lodge, ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Yisrayl Hawkins, Pastor ... article this week that uncovers what he says are the real facts surrounding all ... the Bible from parents and Sunday school teachers, and Yisrayl says there is more ...
(Date:2/12/2016)... ... February 12, 2016 , ... Planet Future ... new cartoon style themes are great for showcasing pictures, videos as well as text ... titles like introductions, lower thirds, transitions and a beautiful frame overlay. Pixel Film Studios ...
(Date:2/12/2016)... ... ... Dignity Health named Dr. Scott Bingham the Facility Medical Director of the ... licensed under Dignity Health Arizona General Hospital , which opened last year in ... our new freestanding emergency room delivers the highest quality care to Mesa and the ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016  Kindred ... focused on saving and improving the lives of pets, ... Technical Section of the New Animal Drug Application (NADA) ... the pivotal field study (KB0120) of Zimeta for the ... by the Company. --> ...
(Date:2/11/2016)... N.Y. , Feb. 11, 2016  Governor Andrew ... that will create 1,400 jobs throughout Western ... a partnership with the SUNY Polytechnic Institute, includes a ... Conventus Building in Buffalo , as ... foot manufacturing facility in Dunkirk . ...
(Date:2/11/2016)... 11, 2016 Potrero Medical, Inc., the developer of ... the appointment of George M. Rapier, III , MD, ... TX , WellMed is one of the nation,s largest ... HMO members in Texas and ... of his own internal medicine practice, he has been instrumental ...
Breaking Medicine Technology: