Navigation Links
Hitting 'reset' in protein synthesis restores myelination
Date:4/26/2013

hese diseases significantly affect quality of life but not longevity, taking a major toll on patients, families and society, the researchers note.

"It's possible that our finding could lead to the development of an effective treatment not just for CMT neuropathies but also for other diseases related to misfolded proteins," says Lawrence Wrabetz, MD, director of the institute and professor of neurology and biochemistry in UB's School of Medicine and Biomedical Sciences and senior author on the paper. Maurizio D'Antonio, of the Division of Genetics and Cell Biology of the San Raffaele Scientific Institute in Milan is first author; Wrabetz did most of this research while he was at San Raffaele, prior to coming to UB.

The research finding centers around the synthesis of misfolded proteins in Schwann cells, which make myelin in nerves. Myelin is the crucial fatty material that wraps the axons of neurons and allows them to signal effectively. Many CMT neuropathies are associated with mutations in a gene known as P0, which glues the wraps of myelin together. Wrabetz has previously shown in experiments with transgenic mice that those mutations cause the myelin to break down, which in turn, causes degeneration of peripheral nerves and wasting of muscles.

When cells recognize that the misfolded proteins are being synthesized, cells respond by severely reducing protein production in an effort to correct the problem, Wrabetz explains. The cells commence protein synthesis again when a protein called Gadd34 gets involved.

"After cells have reacted to, and corrected, misfolding of proteins, the job of Gadd34 is to turn protein synthesis back on," says Wrabetz. "What we have shown is that once Gadd34 is turned back on, it activates synthesis of proteins at a level that's too highthat's what causes more problems in myelination.

"We have provided proof of principle that Gadd34 causes a problem with translational homeostasis and that's what causes some neuropathi
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. ZTL Starts Hitting LED Lighting Market Worldwide
2. Innokin iTaste VV starts hitting Japan e cigarette market
3. Eating Disorders Hitting Women Over 50, Study Finds
4. NIH study sheds light on how to reset the addicted brain
5. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces Medical Weight Loss Capable of Resetting the Metabolism
6. A carefully scheduled high-fat diet resets metabolism and prevents obesity
7. New Instrument for High-Precision Measurements of Soy Milk Solids and Protein Concentration
8. Deficiency in p53 anti-tumor protein delays DNA repair after radiation, Moffitt researchers say
9. Same protein that fires up cancer-promoting Erk also blocks its activation
10. Researchers identify and block protein that interferes with appetite-suppressing hormone
11. Key bone marrow protein identified as potential new leukemia treatment target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... Calgary, AB (PRWEB) February 28, 2015 ... and is now a distributor of the machine. The ... part of their license, like a franchise model. The ... people prevent and reverse heart disease. To buy ... Heart Fit Clinic can help individuals through this process ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 Indosoft ... software suite for Asterisk, are pleased to announce the ... successful 5.7 and 5.8 versions of Q-Suite, this new ... as a number of new features to the leading ... 2015. , Q-Suite 5.9 will add features to enhance ...
(Date:2/28/2015)... February 28, 2015 National ... outsourced sales, marketing and supply chain management for ... Botanicals, is bringing its award winning solutions for ... Botanicals’ products are specifically created to combat thinning-damaged ... BIOTA is committed to marrying science with nature ...
(Date:2/28/2015)... Ohio (PRWEB) February 28, 2015 ... Motivational? Supportive? Strategic? , There are all kinds ... strengths. To raise awareness of the advantages and ... firm PeopleKeys is launching a new product this ... clients better understand the connection between personality type, ...
(Date:2/28/2015)... Janesville, WI (PRWEB) February 28, 2015 ... The designation recognizes Mercy Harvard Hospital as stroke capable ... to be brought via ambulance to Mercy Harvard Hospital. ... the state to indicate their ability to treat stroke ... The designation allows ambulances transporting stroke patients to bypass ...
Breaking Medicine News(10 mins):Health News:Clinicians Can Now Purchase External Counterpulsation with Heart Fit Clinic 2Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 3Health News:PeopleKeys Launches The Leadership Report 2Health News:PeopleKeys Launches The Leadership Report 3Health News:Mercy Harvard Hospital Recognized as Leader in Stroke Care - Javon Bea 2
... Ellis,Healthcare REIT, Inc. has acquired Park Place Office Park ... Park Place Office Park consists of three multi-tenant ... and a half,acres in Dayton, Ohio. Park Place I, ... respectively, and offer tenants a landscaped common area,with a ...
... 500 Jobs, HARRISBURG, Pa., Dec. 28 A ... of the Butler,Memorial Hospital that will include a new ... the Department of Community and,Economic Development announced today. The ... The state,s aid will come in the form ...
... Renovation and Expansion to Create 230 Jobs, ... and,expansion project at the Williamsport Hospital and Medical ... jump-started by a $12.5 million grant,from the commonwealth, ... The commonwealth will offer a total of ...
... Corp. ("Echo" or the "Company") (OTC Bulletin Board: ... meeting of stockholders today,that it was temporarily adjourning ... and vote on the proposed merger transaction,with XLNT ... set forth,in the proxy statement/prospectus previously mailed to ...
... 28 As part of its mission,to provide ... by lupus, the,Lupus Foundation of America (LFA) submitted ... Security Administration (SSA), regarding a,proposed change to the ... people,appealing a social security determination., The proposed ...
... eye procedure helped for at least a decade , , ... and safely corrects severe myopia for at least a ... is caused by excessive curving of the eye,s lens ... to the American Optometric Association, almost one in three ...
Cached Medicine News:Health News:Grubb & Ellis Healthcare REIT Acquires Park Place Office Park in Dayton, Ohio 2Health News:Grubb & Ellis Healthcare REIT Acquires Park Place Office Park in Dayton, Ohio 3Health News:Pennsylvania Invests $13.4 Million to Kick Off Butler Memorial Hospital Expansion 2Health News:Echo Healthcare Extends Stockholder Vote on Proposed Merger With XLNT Veterinary Care to January 4, 2008 2Health News:Echo Healthcare Extends Stockholder Vote on Proposed Merger With XLNT Veterinary Care to January 4, 2008 3Health News:Echo Healthcare Extends Stockholder Vote on Proposed Merger With XLNT Veterinary Care to January 4, 2008 4Health News:Echo Healthcare Extends Stockholder Vote on Proposed Merger With XLNT Veterinary Care to January 4, 2008 5Health News:Lupus Foundation of America Urges Social Security Administration Not to Adopt Proposed 5-Day Rule 2Health News:Laser Surgery Can Correct Nearsightedness 2
(Date:2/27/2015)... -- Bionik Laboratories Corp. (OTC:DWTPD), a Delaware ... Bionik Laboratories, Inc., a Toronto ... accredited investors of units consisting of its common stock ... million. Shares of the Company,s common stock will continue ... symbol "DWTPD" until FINRA,s approval of the ticker "BNKL." ...
(Date:2/26/2015)... 27, 2015 RnRMarketResearch.com adds ... research report to its store. This report p ... pipeline. The report "Corneal Ulcers - Pipeline Review, ... development for Corneal Ulcers. Corneal Ulcers are primarily ... infections, viral infections & fungal infections. The symptoms ...
(Date:2/26/2015)... Feb. 26, 2015  IRIDEX Corporation (NASDAQ: IRIX ... and full year 2014 financial results after the market closes ... the release, the Company will host a conference call with ... Thursday, March 5, 2015 to discuss the ... Interested parties may access the live conference call via telephone ...
Breaking Medicine Technology:Bionik Laboratories Raises $6.2 Million 2Bionik Laboratories Raises $6.2 Million 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2
The ImagingPlanet 80 mm surgical microscope video adapter: superior optical quality and precise engineering make this 80 mm focal length adapter an excellent decision for use with your Zeiss surgical...
The ImagingPlanet 80 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 80 mm focal length adapter an excellent decision for use with your Leica surgical micr...
Introducing Optronics DVMR, the first digital surgical documentation system designed for the microsurgical operating room environment. DVMR accepts images from a variety of high-resolution cameras fo...
... The Optronics MicroFire - Monochrome: ... Monochrome microscope camera with Firewire ... high-efficiency imaging beyond 900nm. The ... with a C-mount adapter and ...
Medicine Products: