Navigation Links
Hip bone density helps predict breast cancer risk

Measuring a woman's bone mineral density can provide additional information that may help more accurately determine a woman's risk of developing breast cancer. That is the conclusion of a new study published in the September 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study's results suggest that incorporating bone mineral density tests with current risk assessments might significantly improve physicians' ability to predict breast cancer risk in older, postmenopausal women.

Bone mineral density testing is done to diagnose osteoporosis and help assess the risk of fractures. Low bone mineral density is linked to higher risk of fractures, while normal density is linked to lower risk of fractures. It is possible that over a woman's lifetime, hormonal and other factors that lead to higher bone mineral density can also lead to higher risk of breast cancer. Studies have found an association between higher bone mineral density and higher breast cancer risk, and bone mineral density tests have been proposed as a potential addition to breast cancer risk models. This study, supported by Eli Lilly & Company, is the first to investigate the relationships among bone mineral density, traditional breast cancer risk assessment tool results, and breast cancer incidence among the same group of postmenopausal women.

To investigate these relationships, Dr. Zhao Chen of the University of Arizona Mel and Enid Zuckerman College of Public Health and her colleagues studied approximately 10,000 post-menopausal women (average age 63) taking part in the Women's Health Initiative, a study conducted in 40 clinical centers throughout the United States and supported by the National Heart, Lung and Blood Institute of the National Institutes of Health. The researchers assessed the women's initial bone mineral density level as well as their score on the Gail risk model, a well known and commonly used tool that estimates five year and lifetime risk of invasive breast cancer for women 35 years of age or older. They then followed the women for an average of approximately 8 years, noting which women developed breast cancer.

As expected, the study found that women with a high Gail score had a 35 percent increased risk of developing breast cancer compared to women with a lower Gail score. But the study also found a 25 percent increase in the risk of developing the disease with each unit increase in total hip bone mineral density t-score. While the two scores were independent of each other, women who had the highest scores on both assessments had a much higher risk in breast cancer.

The findings suggest that adding bone mineral density to currently used risk assessment tools may significantly improve the prediction of breast cancer risk. "Future studies should investigate whether incorporating bone mineral density and Gail score with other risk factors, such as breast density, can further improve the identification of women at high risk for developing breast cancer," the authors wrote. This study also suggests that bone mineral density is a potential alternative for predicting breast cancer risk in postmenopausal women if Gail score is not available. Additional studies are needed to determine if the results from this investigation are applicable to a broader group of women, including minorities. The findings do not change the use of bone mineral density testing to diagnose osteoporosis or the need to treat osteoporosis in order to reduce the risk of fractures.


Contact: Sean Wagner

Related medicine news :

1. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
2. Bone Density Tests Do Predict Womens Fracture Risk
3. Neighborhood ethnic density associated with risk of psychosis among immigrants in the Netherlands
4. First study to examine vitamin D insufficiency in pediatric patients with low bone density
5. Physicists at CCNY determine density limit for randomly packed spherical materials
6. Hand bone mineral density is an effective predictor of mortality in rheumatoid arthritis
7. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
8. Direct Anesthetic Infusion Helps Colorectal Cancer Patients
9. Radiation and drug combo helps boost efficacy of lung cancer treatment
10. Childs Flu Shot Helps Whole Family
11. Microsoft Helps Developers of Clinical User Interfaces Improve Efficiency, Patient Safety With Free Toolkit
Post Your Comments:
(Date:12/1/2015)... ... 01, 2015 , ... TCS Healthcare Technologies (TCS), a leading ... arenas, is pleased to announce that VIP Care Services, a Caprock Health Group ... ACUITY Complete Care™ Management to back their collaborative catastrophic case management initiatives. ACUITY ...
(Date:12/1/2015)... ... December 01, 2015 , ... PartnerTech ... through membership and leadership since 2008. Gary Bruce, President of PartnerTech North America, ... has spent a significant amount of time in Sweden since joining PartnerTech based ...
(Date:12/1/2015)... ... December 01, 2015 , ... Dr. Arash ... Modern Man for 2015. , Angeleno Magazine is a division of Modern ... in 1994, Modern Luxury includes more than 50 magazine titles across 15 major ...
(Date:11/30/2015)... ... November 30, 2015 , ... Third Molar SEO ... it has officially launched a sleek, mobile-ready and user-centric redesigned website. , Vivek ... website clearly outlines the benefits that its SEO services provide to dentists and ...
(Date:11/30/2015)... , ... December 01, 2015 , ... The Turks & ... one of the leading digital news sites highlighting Caribbean destinations, has published five reasons ... While much of North America shivers under chilly grey skies or worse, it's typically ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... -- Pharma Tech Outlook recently conducted a comprehensive investigation ... Solution Providers - 2015 .  After careful consideration of ... VCs, analysts, and the Pharma Tech Outlook editorial board ... clinical data management solution providers (check out the complete ... respectively). --> --> ...
(Date:12/1/2015)... Ohio , Dec. 1, 2015 ... to its GeneSight® Psychotropic test giving healthcare providers an ... medication decisions for patients suffering from depression, anxiety, ... other behavioral health conditions. i ... --> With the addition of two ...
(Date:12/1/2015)... , Dec. 1, 2015  AccuTEC Blades, ... a new corporate logo and brand identity program. ... design and engineering of bladed products where "the ... --> --> Serving manufacturers and ... and auto glass equipment, AccuTEC,s product lines include ...
Breaking Medicine Technology: