Navigation Links
Highly targeted radiation technique minimizes side effects of prostate cancer treatment
Date:10/25/2010

Men with prostate cancer treated with a specialized type of radiation called intensity modulated radiation therapy (IMRT) have fewer gastrointestinal complications compared to patients treated with conventional three-dimensional conformal radiotherapy (3D-CRT), according to a study presented November 1, 2010, at the 52nd Annual Meeting of the American Society for Radiation Oncology (ASTRO).

"With survivors living many years after treatment, it is very important to minimize gastrointestinal and urinary side effects to allow patients to live a full life after treatment," Justin Bekelman, M.D., lead author of the study and a radiation oncologist at the University of Pennsylvania in Philadelphia, said. "We specifically looked at IMRT, given its potential to minimize radiation side effects and its higher cost compared to other treatments. Our study shows there is a benefit for men with prostate cancer to receive IMRT over conventional treatment in terms of gastrointestinal side effects. But there is no difference between the two treatments in terms of urinary side effects."

The prostate gland is near both the rectum and the bladder, so doctors must be very careful to spare these healthy tissues to avoid complications when attacking the cancer.

Prostate cancer is the most common cancer in American men, with more than 185,000 men diagnosed with the disease each year. Fortunately, the disease is very manageable and often curable, with 98 percent of patients living at least five years after their diagnosis.

IMRT and 3D-CRT are special types of external beam radiation therapy where radiation is directed through the skin to the cancer and the immediate surrounding area to destroy the tumor and any stray cancer cells. Treatments are painless, much like receiving an X-ray.

Policymakers and clinicians have highlighted the need for comparative studies of prostate cancer treatments. However, there is little evidence comparing IMRT to conventional radiation therapy. Three-dimensional conformal radiation therapy, or 3D-CRT, uses computers and special imaging techniques such as CT, MR or PET scans to show the size, shape and location of the tumor and surrounding organs. Because the radiation beams are very precisely directed, nearby normal tissue receives less radiation.

Intensity modulated radiation therapy, or IMRT, is a specialized form of 3D-CRT that better shapes the radiation to the tumor. Using IMRT, it may be possible to further limit the amount of radiation received by healthy tissue near the tumor.

This study used the Surveillance, Epidemiology and End Results (SEER)-Medicare database to compare the gastrointestinal and urinary complications of men 65 years or older with prostate cancer within two years of treatment with IMRT or 3D-CRT. The researchers specifically examined common gastrointestinal side effects like inflammation of the rectum lining (proctitis) and rectal bleeding, along with the urinary side effects like inflammation of the bladder tissue (cystitis) and blood in the urine (hematuria).

The study showed that IMRT was associated with a modest reduction in gastrointestinal complications associated with radiation, including proctitis and rectal bleeding. Urinary complications, such as cystitis and hematuria, did not significantly differ between the groups.


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-839-7332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
2. Lead poisoning highly prevalent among school-aged children in Uganda
3. New weapon against highly resistant microbes within grasp
4. Whole body MRI is highly accurate in the early detection of breast cancer metastases
5. Swedes think highly of the government -- but not of the royal family
6. Life Coach and Author Thomas Finn's Highly Anticipated Book, 'A Better Tomorrow- Affirmations and Visualizations the Keys to Success,' Debuts June 15
7. 15 years after ACL knee reconstruction, 84 percent of male patients still highly active, study says
8. FDA Appoints Highly Qualified Scientific Experts to Tobacco Products Scientific Advisory Committee
9. Sexual issues a major concern for cancer patients taking new targeted drugs
10. Targeted therapy promising for HER2-positive metastatic breast cancer
11. Evaluation of targeted therapy in ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... Loma Linda, CA (PRWEB) , ... May 24, 2016 , ... ... that will house the new adult hospital and expanded Children’s Hospital. Over 3,000 people ... May 22. , Check out the event photo slidehsow. , During the ...
(Date:5/24/2016)... Angeles, CA (PRWEB) , ... May 24, 2016 ... ... to everything egg freezing, today announced the official relaunch of its community and ... use their frozen eggs. Eggsurance's mission is to create a safe and welcoming ...
(Date:5/24/2016)... ... ... Tuesday, May 24, Women's Excellence in Wellness, powered by Movestrong will be ... taught by Patti Dolan, RYT, a Young Living Gold Member. The class is ... 7:15pm followed by a small intro to the Oils that can benefit the student's ...
(Date:5/24/2016)... ... ... In light of recent heavy flooding in Houston, Texas, Pelican Water Systems is ... Houston area. , Heavy floodwaters have led to destroyed waterways and flooded reservoirs. The ... even be aware of the contamination of their water supply and thus, may be ...
(Date:5/24/2016)... ... May 24, 2016 , ... "ProText Layouts Vol. 3 ... Austin - CEO of Pixel Film Studios. , ProText Layouts Vol. 3 is a ... Cut Pro X . With ProText Layouts, video editors can create an lively typography ...
Breaking Medicine News(10 mins):
(Date:5/20/2016)... May 20, 2016 The Biotech ... believe that the industry is not far from recovering. ... ActiveWallSt.com featured the following four equities: Anacor Pharmaceuticals Inc. ... ATHX ), Aralez Pharmaceuticals Inc. (NASDAQ: ... INFI ). Sign up for your free trading alerts ...
(Date:5/20/2016)... According to the 2016 home healthcare market report, ... healthcare solutions as since the early 2000s, the cost of ... the US, the healthcare cost rose faster than inflation during ... inflation rate stood at an average of 2.04% during 2005-2015, ... the same time period. This can be attributed to the ...
(Date:5/19/2016)... May 19, 2016  According to the World ... world lacks basic diagnostic imaging. Whereas mammography or ... the United States , many places around ... In fact, the WHO reports that those approximately ... or treatable death, simply due to the unavailability ...
Breaking Medicine Technology: