Navigation Links
Highly targeted radiation technique minimizes side effects of prostate cancer treatment
Date:10/25/2010

Men with prostate cancer treated with a specialized type of radiation called intensity modulated radiation therapy (IMRT) have fewer gastrointestinal complications compared to patients treated with conventional three-dimensional conformal radiotherapy (3D-CRT), according to a study presented November 1, 2010, at the 52nd Annual Meeting of the American Society for Radiation Oncology (ASTRO).

"With survivors living many years after treatment, it is very important to minimize gastrointestinal and urinary side effects to allow patients to live a full life after treatment," Justin Bekelman, M.D., lead author of the study and a radiation oncologist at the University of Pennsylvania in Philadelphia, said. "We specifically looked at IMRT, given its potential to minimize radiation side effects and its higher cost compared to other treatments. Our study shows there is a benefit for men with prostate cancer to receive IMRT over conventional treatment in terms of gastrointestinal side effects. But there is no difference between the two treatments in terms of urinary side effects."

The prostate gland is near both the rectum and the bladder, so doctors must be very careful to spare these healthy tissues to avoid complications when attacking the cancer.

Prostate cancer is the most common cancer in American men, with more than 185,000 men diagnosed with the disease each year. Fortunately, the disease is very manageable and often curable, with 98 percent of patients living at least five years after their diagnosis.

IMRT and 3D-CRT are special types of external beam radiation therapy where radiation is directed through the skin to the cancer and the immediate surrounding area to destroy the tumor and any stray cancer cells. Treatments are painless, much like receiving an X-ray.

Policymakers and clinicians have highlighted the need for comparative studies of prostate cancer treatments. However, there is little evidence comparing IMRT to conventional radiation therapy. Three-dimensional conformal radiation therapy, or 3D-CRT, uses computers and special imaging techniques such as CT, MR or PET scans to show the size, shape and location of the tumor and surrounding organs. Because the radiation beams are very precisely directed, nearby normal tissue receives less radiation.

Intensity modulated radiation therapy, or IMRT, is a specialized form of 3D-CRT that better shapes the radiation to the tumor. Using IMRT, it may be possible to further limit the amount of radiation received by healthy tissue near the tumor.

This study used the Surveillance, Epidemiology and End Results (SEER)-Medicare database to compare the gastrointestinal and urinary complications of men 65 years or older with prostate cancer within two years of treatment with IMRT or 3D-CRT. The researchers specifically examined common gastrointestinal side effects like inflammation of the rectum lining (proctitis) and rectal bleeding, along with the urinary side effects like inflammation of the bladder tissue (cystitis) and blood in the urine (hematuria).

The study showed that IMRT was associated with a modest reduction in gastrointestinal complications associated with radiation, including proctitis and rectal bleeding. Urinary complications, such as cystitis and hematuria, did not significantly differ between the groups.


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-839-7332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
2. Lead poisoning highly prevalent among school-aged children in Uganda
3. New weapon against highly resistant microbes within grasp
4. Whole body MRI is highly accurate in the early detection of breast cancer metastases
5. Swedes think highly of the government -- but not of the royal family
6. Life Coach and Author Thomas Finn's Highly Anticipated Book, 'A Better Tomorrow- Affirmations and Visualizations the Keys to Success,' Debuts June 15
7. 15 years after ACL knee reconstruction, 84 percent of male patients still highly active, study says
8. FDA Appoints Highly Qualified Scientific Experts to Tobacco Products Scientific Advisory Committee
9. Sexual issues a major concern for cancer patients taking new targeted drugs
10. Targeted therapy promising for HER2-positive metastatic breast cancer
11. Evaluation of targeted therapy in ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2017)... ... April 22, 2017 , ... The San Juan Capistrano summer camp team at ... outlining the need for summer camps to provide physical activities for all campers. To read ... In Summer Camps , With an increase in specialty camps that focus on what the ...
(Date:4/21/2017)... ... , ... The staff at Palm Beach Face is proud to announce that their practice founder, ... Set to take place on April 23rd, the London Marathon has a long tradition of ... part of team EMPOWER, raising money for the international charity, Smile Train. , ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... and young adults, has kicked off its 4th annual Forum for Innovative Treatment ... theme is “Attachment Informed Therapy for Mental Health and Addiction.” , FITS’ ...
(Date:4/21/2017)... ... April 21, 2017 , ... Dudnyk has announced the launch of ... conviction that the full potential of specialty and orphan brands can only be achieved ... , “The Unifying Effect is at the heart of a true partnership between ...
(Date:4/21/2017)... ... April 21, 2017 , ... The VIA ... Record (AOR) for Theravent, Inc. , the makers of a revolutionary new ... Consumer Healthcare, is now working to expand distribution in anticipation of a national ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  Zimmer Biomet Holdings, ... musculoskeletal healthcare, today announced that it will be participating ... Conference at the InterContinental Hotel in Boston, ... Biomet will present at 11:20 a.m. Eastern Time. ... accessed via Zimmer Biomet,s Investor Relations website at ...
(Date:4/20/2017)... MARLBOROUGH, Mass. , April 20, 2017 /PRNewswire/ ... company developing innovative therapeutics that address significant unmet ... new data from the Company,s consumer product development ... technology, at the Society for Investigative Dermatology (SID) ... is to advance and promote the sciences relevant ...
(Date:4/20/2017)... April 20, 2017  CVS Pharmacy, the retail ... a new store design to enhance the retail ... food, health-focused products and expanded beauty selections paired ... customers discover new offerings. Together with its innovative ... of the customer experience at CVS Pharmacy.  ...
Breaking Medicine Technology: