Navigation Links
Highly targeted radiation technique minimizes side effects of prostate cancer treatment
Date:10/25/2010

Men with prostate cancer treated with a specialized type of radiation called intensity modulated radiation therapy (IMRT) have fewer gastrointestinal complications compared to patients treated with conventional three-dimensional conformal radiotherapy (3D-CRT), according to a study presented November 1, 2010, at the 52nd Annual Meeting of the American Society for Radiation Oncology (ASTRO).

"With survivors living many years after treatment, it is very important to minimize gastrointestinal and urinary side effects to allow patients to live a full life after treatment," Justin Bekelman, M.D., lead author of the study and a radiation oncologist at the University of Pennsylvania in Philadelphia, said. "We specifically looked at IMRT, given its potential to minimize radiation side effects and its higher cost compared to other treatments. Our study shows there is a benefit for men with prostate cancer to receive IMRT over conventional treatment in terms of gastrointestinal side effects. But there is no difference between the two treatments in terms of urinary side effects."

The prostate gland is near both the rectum and the bladder, so doctors must be very careful to spare these healthy tissues to avoid complications when attacking the cancer.

Prostate cancer is the most common cancer in American men, with more than 185,000 men diagnosed with the disease each year. Fortunately, the disease is very manageable and often curable, with 98 percent of patients living at least five years after their diagnosis.

IMRT and 3D-CRT are special types of external beam radiation therapy where radiation is directed through the skin to the cancer and the immediate surrounding area to destroy the tumor and any stray cancer cells. Treatments are painless, much like receiving an X-ray.

Policymakers and clinicians have highlighted the need for comparative studies of prostate cancer treatments. However, there is little evidence comparing IMRT to conventional radiation therapy. Three-dimensional conformal radiation therapy, or 3D-CRT, uses computers and special imaging techniques such as CT, MR or PET scans to show the size, shape and location of the tumor and surrounding organs. Because the radiation beams are very precisely directed, nearby normal tissue receives less radiation.

Intensity modulated radiation therapy, or IMRT, is a specialized form of 3D-CRT that better shapes the radiation to the tumor. Using IMRT, it may be possible to further limit the amount of radiation received by healthy tissue near the tumor.

This study used the Surveillance, Epidemiology and End Results (SEER)-Medicare database to compare the gastrointestinal and urinary complications of men 65 years or older with prostate cancer within two years of treatment with IMRT or 3D-CRT. The researchers specifically examined common gastrointestinal side effects like inflammation of the rectum lining (proctitis) and rectal bleeding, along with the urinary side effects like inflammation of the bladder tissue (cystitis) and blood in the urine (hematuria).

The study showed that IMRT was associated with a modest reduction in gastrointestinal complications associated with radiation, including proctitis and rectal bleeding. Urinary complications, such as cystitis and hematuria, did not significantly differ between the groups.


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-839-7332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
2. Lead poisoning highly prevalent among school-aged children in Uganda
3. New weapon against highly resistant microbes within grasp
4. Whole body MRI is highly accurate in the early detection of breast cancer metastases
5. Swedes think highly of the government -- but not of the royal family
6. Life Coach and Author Thomas Finn's Highly Anticipated Book, 'A Better Tomorrow- Affirmations and Visualizations the Keys to Success,' Debuts June 15
7. 15 years after ACL knee reconstruction, 84 percent of male patients still highly active, study says
8. FDA Appoints Highly Qualified Scientific Experts to Tobacco Products Scientific Advisory Committee
9. Sexual issues a major concern for cancer patients taking new targeted drugs
10. Targeted therapy promising for HER2-positive metastatic breast cancer
11. Evaluation of targeted therapy in ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's (ABFM) Board ... Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will ... Dr. Puffer’s retirement at the end of 2018. Upon assuming the role of President ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and ... Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD ... that can be easily incorporated into liquid products, while reducing costs to end users. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder ... of ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership ... rules. It also provides a forum to network with elder law attorneys nationwide,” said ...
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... New York, NY (PRWEB) , ... October 13, 2017 , ... ... most influential people in business to advocate for action towards gender equality at their ... 18,000 views from around the globe, and reached a social audience of over 3 ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... ALLENTOWN , Pa. and KALAMAZOO, Mich. ... Allentown, Penn. , and OptiMed Specialty Pharmacy ... a business partnership to offer a strategic hub service ... PMD Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, ... A spirometer is a medical device used ...
(Date:9/12/2017)... YORK , Sept. 12, 2017   EcoVadis , the leading ... has published the first annual edition of its Global CSR Risk and ... companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 ... ... Index ...
(Date:9/9/2017)... , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September 18 ... D.C. offering free MRI brain scans to the public.Where:  ... be parked at 501 K Street NW, Washington, D.C.What:BTF brings its nationwide ...
Breaking Medicine Technology: