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Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
Date:5/11/2012

Barcelona, Spain: Using a concentrated, highly targeted dose of radiation to the breast has equally good results as irradiating the whole area, with no adverse effects on survival and a much better cosmetic outcome, Hungarian researchers have found. Reporting the ten-year results of a randomised trial, Professor Csaba Polgr, MD, Director of the Centre for Radiotherapy, National Institute of Oncology, Budapest, will tell the World Congress of Brachytherapy [1 & 2] today (Friday) that he believes that accelerated partial breast irradiation (APBI) could be offered to many more breast cancer patients, resulting in fewer side effects and major cost savings to healthcare systems.

The Budapest trial was the first randomised study to compare the efficacy and side effects of conventional whole breast irradiation with APBI using multicatheter brachytherapy. This technique consists of inserting multiple plastic catheters into the tumour bed after breast conserving surgery. The catheters are inserted under local or general anaesthesia, according to the wishes of the patient. The radiation source is then loaded into them to deliver a highly concentrated dose to the precise region of the excised tumour the region most likely to develop a local recurrence of the cancer. Using APBI means that the major part of the healthy breast tissue does not receive radiation.

"In a group of 258 women who had had breast-conserving surgery, we found that, at a median follow-up time of just over ten years, the rate of local recurrence the cancer coming back in the same place was 5.9% in the APBI group and 5.1% in the group who received whole breast irradiation," says Professor Polgr. "There was no significant difference in overall survival, cancer-specific survival, and disease free survival between the two groups. However, the differences in cosmetic outcome were striking 81% in the APBI group had good-to-excellent results as opposed to 63% of those who received whole b
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Contact: Mary Rice
mary.rice@riceconseil.eu
European Society for Radiotherapy and Oncology (ESTRO)
Source:Eurekalert

Page: 1 2 3

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